Bioscientifics Research Group

05/02/2025

*WELCOME TO THE MONTH OF LOVE AND PROFESSIONAL GROWTH
* HOW IS YOUR PHARMACOKINETICS HANDLE AS A PHARMACIST?

*Join the February webinar on Simplified Pharmacokinetics
Register early limited slots available
*Date: 26th to 28th February., 25
Time 4 to 6pm
Fee: #20,000
Account: FCMB2005095796
SOLJAY BIOSCIENTIFIC R/D*


*Question 1*
A patient GY, female 44 years and BMI 23.5 is administered 500 mg of am antibacterial drug orally with dosing intervals of 12h for 10 days, and a bioavailability of 0.8.

If the clearance of the drug is 10 L/h, what is the steady-state concentration (Css) of the drug in the plasma?

Furthermore , if the MEC - MTC is 4.5 - 7.6mg/L, as a pharmacist what do I advise?

*Answer*
First, calculate the dose that actually enters the systemic circulation:
Dose(D) x Bioavailability (F) = 500 mg x 0.8 = 400 mg

Then, convert the dose to milligrams per hour:
400 mg / 12 h (dosing interval) = 33.33 mg/h

Now, calculate Css:
Css = Dose / Clearance = 33.33 mg/h

Is this not fun. Let's row!

04/02/2025

*Pharmacokinetic Perspective to Practice as a Pharmacist in the Community*

A patient UT, male 47 years old and BMI 31, attending a community pharmacy is 7 prescribed a dose of 1000 mg of a drug that has a volume of distribution (Vd) of 0.5 L/kg. If the patient weighs 50 kg, what is the resulting plasma concentration (Cp) of the drug?

*Solution*
First, calculate the total volume of distribution (Vd) in liters:

Vd = 0.5 L/kg × 50 kg = 25 L.
Then, calculate the plasma concentration (Cp) in mg/L:
Cp = dose / Vd = 1000 mg / 25 L = 40 mg/L.

Pertinent questions
1. Was this drug given by IV, oral, IM and how does this route affect the CP?
2. What is Bioavailability (F)?
3. What role does the BMI play if the drug is hydrophilic and highly protein-bound?
4. Can you list 10 of such drugs in your pharmacy?
PI, Bioscird

04/02/2025

Good morning distinguished colleagues, this is the
kind of challenges we will be tackling this February edition of Bioscird Ltdgte Month-end Seminars.

We have room for max 20 participants for an effective and satisfying experience.

Kindly register early if interested

Preamble
Drugs work perfectly when the plasma concentration (CP) is at the therapeutic level (above MEC and below MTC).
This is where safety and efficacy is guaranteed, so let's look at this case as a community pharmacist
*Question 1*
A patient BH, male 67 years and BMI 24.5 is prescribed a dose of 500 mg of a drug VGH an antihypertensive, that has a volume of distribution (Vd) of 0.2 L/kg. If the patient weighs 70 kg, what is the resulting plasma concentration (Cp) of this drug?

Clinical pharmacists should be able to handle cases in this professional way.

Simplified pharmacokinetics is the webinar titled for February 26th to 28th 2025

04/02/2025

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03/02/2025

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