05/12/2026
For years, iPSC reprogramming has faced a difficult trade-off: higher efficiency often came at the cost of genomic stability, frequently involving p53 suppression.
A new study published in Cell Press by Deng Hongkui’s team at Peking University challenges this long-standing view. In chemical reprogramming (CiPSC), which avoids exogenous genes, p53 was shown to act not as a barrier, but as a key safeguard for both cell fate fidelity and genome integrity — a major conceptual shift for stem cell biology and regenerative medicine (Read the paper: DOI: 10.1016/j.cell.2026.03.038).
In this work, Fibronectin from ACROBiosystems supported cell adhesion and viability during early-stage reprogramming, helping establish a reliable starting environment.
Beyond Fibronectin, we offer a broad portfolio of RG, PG, and GMP-grade ECM proteins — including Laminin 521, Laminin 511, and Vitronectin — supporting iPSC/MSC culture and multiple clinical-stage cell therapy programs spanning T/NK cells, pancreatic islets, neural cells, cardiomyocytes, and RPE differentiation.
Explore our ECM portfolio: https://www.acrobiosystems.com/category/cell-culture-reagents/ecm-proteins?utm_source=facebook&utm_medium=social&utm_campaign=4363Cg115&utm_content=TGJXEN32884&utm_term=0512