Biosplice Therapeutics

Biosplice Therapeutics Biosplice Therapeutics, Inc. is a clinical-stage biotech developing lorecivivint (SM04690), an investigational intra-articular therapy for knee osteoarthritis.

Biosplice is developing first-in-class, small-molecule therapeutics based on pioneering science of alternative pre-mRNA splicing. Stemming from foundational discoveries in Wnt pathway modulation, Biosplice has elucidated novel biology linking CLK/DYRK kinases to the therapeutic regulation of alternative splicing. Alternative splicing is an essential biological mechanism that regulates the diversif

ication of proteins in a cell, which, in turn, determines cell type and function. Biosplice’s target class governs the selection of tissue-specific mRNA splice sites, making them attractive, druggable targets within the cellular “command and control” center. Biosplice’s drugs in clinical development include lorecivivint for osteoarthritis (in Phase 3), cirtuvivint for numerous cancers, and a broad pipeline that ranges from Alzheimer’s disease to other degenerative conditions. Learn more at https://www.biosplice.com

Welcome to our page. We look forward to the opportunity to engage with you and would like to share some basic ‘house rules’ to encourage everybody to get the most from the community. We work in a regulated industry and because of the unique legal situation in the healthcare space, we can't engage in sensitive topics, or discussion(s) about products - ours or other companies' - or treatment options on this page. As a result, we want to make sure that the discussions that take place on the timeline stay on topic and are constructive. If your comment doesn’t comply with the following basic rules, it may be delayed, or in some cases, not be published:
1. If your posts are product related;
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12. If your posts don’t follow Facebook's posting guidelines and Terms of Use. If you are a subject in one of our clinical trials, to help make sure that the data from the study is as accurate and reliable as possible, please do not discuss information about the study in public places while the study is in progress. Public places may be situations like support groups, internet messaging boards, or social media. If you are interested in any of our clinical trials, please visit www.clinicaltrials.gov and type “Biosplice” into the search bar. Please be aware that fans who continuously and repeatedly contravene the above rules may be removed from our fan list. In this case the user would no longer be able to follow our news, comment on our posts, or send us messages. This community is English speaking only and as such any non-English language content will be removed. If you believe that you have experienced any medical side effects or reactions from a Samumed product you should consult your physician. We suggest sharing as little personal information as possible on the page. In particular, sharing any specific data concerning your personal health should be avoided. Should you, however, decide to include a post detailing any side effects, Biosplice Therapeutics may need to contact you to find out more information. Posts of this nature may not appear or may need to be removed from our page; this is due to legal obligations concerning drug safety reporting. We do not aim to store or use your Facebook profile unique ID, email, or other personal details. Please note that Facebook also has access to information you share with us. For more details read the Facebook Privacy Policy. Thank you for reading and being a part of the community.

Without a treatment that changes the disease itself, the trajectory is steep: knee OA is projected to affect 642 million...
07/17/2026

Without a treatment that changes the disease itself, the trajectory is steep: knee OA is projected to affect 642 million people worldwide by 2050.

And today, every available option only manages pain — none stops the damage. The need for better is only growing. Follow along as we share the facts.

As of 2026, there is still no FDA-approved drug that can stop or slow knee osteoarthritis. Every option only manages the...
07/15/2026

As of 2026, there is still no FDA-approved drug that can stop or slow knee osteoarthritis. Every option only manages the symptoms.

Patients have a voice in changing that. The more people who understand the gap, the more pressure there is for better treatments.

Follow along as we share the facts about knee OA.

Many people with knee OA are offered steroid injections. But here's what one notable trial found.In a 2-year randomized ...
07/13/2026

Many people with knee OA are offered steroid injections. But here's what one notable trial found.

In a 2-year randomized study, patients who received repeated steroid injections in an arthritic knee actually lost more cartilage than those given a saltwater placebo — and reported no better pain relief.

The options we have fall short. Follow along as we share the facts.

Knee OA pain isn't occasional. For most people living with it, it's a daily presence — shaping every step, every plan, e...
07/10/2026

Knee OA pain isn't occasional. For most people living with it, it's a daily presence — shaping every step, every plan, every morning.

It's an invisible, constant companion that others rarely see. If that's your reality, you're not alone. Follow along as we share the facts about knee OA.

Knee osteoarthritis is expensive — for patients and for the whole system.In 2018, knee replacement totaled roughly $11.9...
07/08/2026

Knee osteoarthritis is expensive — for patients and for the whole system.

In 2018, knee replacement totaled roughly $11.9 billion across more than 700,000 US hospital stays, averaging about $16,800 per stay — making it the #2 operating-room procedure in total US hospital spending (driven by sheer volume).

Imagine being able to treat the disease earlier instead. Follow along as we share the facts.

Knee osteoarthritis isn't only about aging — for many people, it's about a lifetime of hard physical work.Workers in phy...
07/06/2026

Knee osteoarthritis isn't only about aging — for many people, it's about a lifetime of hard physical work.

Workers in physically demanding jobs (such as farmers, builders, floor layers, and metal workers) have about 52% higher odds of knee OA than people in sedentary jobs, according to a meta-analysis of 71 observational studies.

Knee OA reaches people in their working prime. Follow along as we share the facts.

Most people reach for acetaminophen (Tylenol) for knee OA pain. But here's what the research shows.A 2015 review in The ...
07/03/2026

Most people reach for acetaminophen (Tylenol) for knee OA pain. But here's what the research shows.

A 2015 review in The BMJ found acetaminophen gives knee and hip OA patients only about 4 points of relief on a 100-point pain scale — too small to be meaningful to patients — while raising the risk of abnormal liver tests.

The options we have fall short. Follow along as we share the facts.

Knee osteoarthritis doesn't affect everyone equally.Women are nearly 70% more likely to develop knee OA than men — and t...
07/01/2026

Knee osteoarthritis doesn't affect everyone equally.

Women are nearly 70% more likely to develop knee OA than men — and tend to develop it earlier. It's one of the clearest patterns in the research, and a reason knee OA deserves far more attention than it gets.

Follow along as we share the facts.

Ever hurt your knee — playing sports, on the job, or just in everyday life?More than 1 in 2 people with a prior knee inj...
06/29/2026

Ever hurt your knee — playing sports, on the job, or just in everyday life?

More than 1 in 2 people with a prior knee injury go on to develop painful knee arthritis. A single injury can set a trajectory that plays out for decades.

Follow along as we share the facts about knee OA.

Here's the reality of knee osteoarthritis treatment in 2026:Every available treatment manages pain — none can repair the...
06/26/2026

Here's the reality of knee osteoarthritis treatment in 2026:

Every available treatment manages pain — none can repair the joint, restore cartilage, or stop the disease from progressing. And as of 2026, there is still no FDA-approved drug that stops or slows knee OA. Not one.

People are managing a progressive disease with options that only touch the symptoms. That needs to change. Follow along as we share the facts.

Address

6555 Nancy Ridge Drive
San Diego, CA
92121

Opening Hours

Monday 9am - 5pm
Tuesday 9am - 5pm
Wednesday 9am - 5pm
Thursday 9am - 5pm
Friday 9am - 5pm

Telephone

+18589262900

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