09/09/2024
Increased Vitamin D Intake May Help Prevent Dementia, Study Shows
Morgan Chamberlain
Author: Morgan Chamberlain
September 07, 2024
Research indicates that one essential vitamin could make all the difference in cognitive decline and brain longevity: vitamin D.
According to an observational study published in Alzheimer's & Dementia, older adults who increased their vitamin D intake were 40% less likely to develop dementia.
The study also learned quite a bit about how individual factors (e.g., demographics, genetics, behavior) play into the equation.
The dementia study design
Researchers evaluated the effects of vitamin D exposure on dementia incidence in 12,388 older adults (average age 71) from the National Alzheimer's Coordinating Center (NACC) data set.
All participants were dementia-free at the baseline evaluation and given one of the following cognitive diagnoses:
Normal cognition
Mild cognitive impairment (MCI)
Additionally, participants were split up into a vitamin-D-exposed group (i.e., individuals that took one of three types of vitamin D supplements—D2, D3, or a combination of vitamin D and calcium—before the baseline exam) and a non-exposed group (i.e., individuals that did not increase their vitamin D intake via supplementation throughout the study).
Can vitamin D exposure predict cognitive decline outcomes?
When looking at demographics, genetics, and myriad other factors, the influence of vitamin D exposure on dementia incidence and survival varied from group to group in interesting ways.
Vitamin D exposure was associated with 40% lower dementia incidence rate than no exposure.
The five-year survival rate for the vitamin D exposure group was also 15% higher than no exposure.
Of the participants that developed dementia over 10 years, 75% had no exposure to vitamin D prior to their diagnosis.
Women were at higher risk of dementia than men but also responded to increased vitamin D intake 23% better (females with vitamin D exposure had 49% lower incidence rate than females with no exposure).
Unsurprisingly, participants with normal cognition at baseline had a lower dementia incidence rate than participants with MCI. However, individuals with MCI in the vitamin D exposure group still had 33% lower incidence than participants with MCI that had no exposure.
The rate was the same in vitamin-D-exposed carriers of the APOE ε4 gene (a biomarker for Alzheimer's disease)—their dementia incidence was 33% lower than carriers that had no exposure.
Overall, increased vitamin D intake was found to have potential for dementia prevention, particularly before the onset of cognitive decline.
While other studies have found that vitamin D deficiency increases the risk of dementia by one-third and higher brain concentrations of vitamin D are linked to positive cognitive health outcomes, participants' blood serum vitamin levels were not documented in this study.
Researchers did not define the amount of vitamin D that each participant in the positive exposure group consumed either, so limited conclusions can be drawn from this observational study.
If you'd like to achieve truly optimal vitamin status to support your cognitive longevity, the most effective way to do so is with a high-potency daily vitamin D supplement to help you reach (and sustain) vitamin D sufficiency.
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