Wishart Node

05/22/2026

📢 One of the most cited articles in Nucleic Acids Research!
We are excited to share that our recent publication in Nucleic Acids Research — “The Natural Products Magnetic Resonance Database (NP-MRD) for 2025” — has become one of the journal’s most-cited recent articles, highlighting its strong impact and growing relevance across the scientific community.
The NP-MRD is a freely accessible, web-based platform designed for the deposition, sharing, and retrieval of NMR data on natural products. Originally developed to support compound de-replication and data sharing, it has rapidly evolved into a major global resource now widely used across metabolomics, microbiomics, foodomics, and nutrition science.
Since its launch, the database has seen remarkable growth:
📈 ~7× increase in compounds (281,859 total)
📊 ~7× increase in NMR spectra (5.5 million total)
🔬 Millions of predicted and simulated spectra added
🌍 Major expansion in global usage and community engagement
This growth has been matched by continuous improvements in data submission tools, spectral search capabilities, and analytical support—strengthening NP-MRD as a key infrastructure for the natural products community.
We are deeply grateful to all co-authors, contributors, and users who have helped make NP-MRD a widely used and highly cited resource.

Abstract. The Natural Products Magnetic Resonance Database (NP-MRD; https://np-mrd.org) is a comprehensive, freely accessible, web-based resource for the d

04/10/2026

🔬 Now Available: Cardiovascular Metabolomic Panel
Advance cardiovascular research with targeted metabolite profiling designed to support biomarker discovery, mechanistic insights, and translational applications.
Our panel covers key metabolite classes involved in:
inflammation, oxidative stress, lipid metabolism, mitochondrial function, and the gut–heart axis.
🧪 Includes:
Amino acids • Biogenic amines • Tryptophan metabolites • Organic acids • Fatty acids • Lipids • More
Custom panel design is also available.
📩 Contact us to learn more or request a quote.
[email protected]

https://www.tmicwishartnode.ca/static/Cardiovascular_Panels.pdf

04/08/2026

A promising step toward more accessible metabolic monitoring 🧪🌍
A recent study describes a rapid, low-cost colorimetric multimetabolite assay for the quantitative measurement of urinary keto acids associated with phenylketonuria (PKU) and maple syrup urine disease (MSUD). Unlike many current approaches that are either qualitative or require specialized laboratory equipment, this method was designed to support simple, at-home monitoring with quantitative readouts in just minutes.
This kind of innovation has the potential to make a meaningful difference for individuals and families managing inborn errors of metabolism, particularly in settings where access to advanced metabolic clinics is limited. Expanding reliable, user-friendly tools for screening, detection, and dietary monitoring is an important step toward more equitable and proactive metabolic care.

https://pubmed.ncbi.nlm.nih.gov/41767879

Inborn errors of metabolism such as phenylketonuria (PKU) and maple syrup urine disease (MSUD) can cause severe developmental problems. Both conditions can lead to harmful levels of keto acids in biofluids-phenylpyruvic acid (PPA) in PKU and branched-chain α-keto acids in MSUD. Monitoring urinary k...

04/07/2026

April is Parkinson’s Awareness Month 💙🧠
Parkinson’s disease is often recognized only after motor symptoms appear — but by then, underlying biological changes may have been developing for years.
A recent study highlights the potential of a five-metabolite blood-based signature, combined with early non-motor symptoms, to help identify Parkinson’s disease earlier and more accurately. This work underscores how metabolomics and biomarker discovery can support earlier detection, improved risk stratification, and more personalized approaches in neurodegenerative disease.
As we recognize Parkinson’s Awareness Month, this research reinforces the importance of advancing early diagnosis, systems biology, and precision health — not only for better outcomes, but for understanding disease long before clinical symptoms emerge.
Explore more here:

https://pubmed.ncbi.nlm.nih.gov/41565969

Parkinson's disease (PD) urgently requires blood-based markers that flag pathology before disabling motor decline. This study measured absolute concentrations of 144 plasma metabolites in 20 neurologically healthy adults and in 40 PD patients clinically classified as intermediate (PD-I) or progressi...