13/08/2026
Research Spotlight | SCIENTZ-150 in Ferritin Nanocage Research
How can ferritin nanocages help enable earlier tumor diagnosis and treatment?
A study published in Science China Life Sciences investigated engineered human heavy-chain ferritin (HFn) nanocages for early tumor theranostics. The researchers developed IRDye800-M-HFn nanoprobes for multimodal tumor imaging and an HFn-Dox system for targeted drug delivery.
Study highlight:
“Engineered nanocarriers have been widely developed for tumor theranostics. However, the delivery of imaging probes or therapeutic drugs to the tumor pre-formation site for early and accurate detection and therapy remains a major challenge.”
The study found that HFn could pe*****te pre-solid tumor sites through inflammation-mediated blood vessel leakage and subsequently accumulate in tumor cells through its targeting interaction with transferrin receptor 1. The HFn-Dox system was then used to deliver doxorubicin to early-stage tumor sites.
Importantly, during HFn preparation, the researchers used a SCIENTZ-150 high-pressure homogenizer to break the HFn-pET-30a-BL21 E. coli cells at 4°C.
About SCIENTZ-150
SCIENTZ-150 is a bench-top high-pressure homogenizer designed for biological sample processing, cell disruption, homogenization and nano-scale material processing.
• Max. working pressure: 1500 bar
• Flow rate: 6–12 L/h
• Built-in cooling system
• Temperature-controllable sample processing
• 316L stainless-steel material-contact components
• Suitable for biological and biopharmaceutical R&D
• Particle size can be refined to below 100 nm with high crushing efficiency, depending on the application and material
From microbial cell disruption to nanomaterial and biopharmaceutical research, reliable sample preparation can be an important step toward reproducible results.
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