22/11/2020
Über 70.000 Studien VOR Covid und über 40 gute Studien SEIT Covid. Und alle zeigen das gleiche :
Vitamin D senkt das Infektionsrisiko
Vitamin D senkt das Erkrankungsrisiko
Vitamin D senkt das Risiko eines schweren Verlaufes
30 randomisierte, kontrollierte Studien sind gerade registriert, die sich angucken, ob Vitamin D möglicherweise nicht sogar einen grösseren Infektionsschutz und Erkrankungsschutz vor COVID bietet als die Impfung das tut.
Über 45.000 Studien zeigen zudem, dass tägliches, moderates Training von 45 Minuten bei etwa 60% der maximalen Herzfrequenz das Infektionsrisiko aller viralen Erkrankungen um 50% reduziert.
Zahlreiche Studien zeigen ausserdem, dass tägliches, moderates Training den Impfschutz nach einer Impfung verlängert.
In einer randomisierten, kontrollierten Studie mit Senioren hat sich gezeigt, dass die Senioren, die 3x/Woche Sport machen eine doppelt so gute Immunantwort auf die Impfung haben, wie die Senioren, die nichts machen.
Möge das MOJO mit euch bleiben! 😘
Hier erstmal die neuen Studien zu Vitamin D und COVID :
[1] Kattner. L., & Volmer D. (11th Nov 2015) Synthesis of Low Abundant Vitamin D Metabolites and Assaying Their Distribution in Human Serum by Liquid Chromatography-Tandem Mass Spectrometry (LCMS/MS) as a New Tool for Diagnosis and Risk Prediction of Vitamin D-Related Diseases http://dx.doi.org/ 10.5772/64518 Available at https://www.intechopen.com/books/a-critical-evaluation-of-vitamin-d-basi...
[2] Wolf, G. (June 2004) The Discovery of Vitamin D: The Contribution of Adolf Windaus, The Journal of Nutrition, Volume 134, Issue 6, Pages 1299–1302, https://doi.org/10.1093/jn/134.6.1299 Available at https://academic.oup.com/jn/article/134/6/1299/4688802
[3] Hidalgo, A., Trump, D., & Johnson, C. (2010). Glucocorticoid regulation of the vitamin D receptor. The Journal of steroid biochemistry and molecular biology, 121(1-2), 372–375. https://doi.org/10.1016/j.jsbmb.2010.03.081 Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907065/
[4] Navarro-Barriuso, J., Mansilla, M.J., Naranjo-Gómez, M. et al. (2018). (Fig. 3) Comparative transcriptomic profile of tolerogenic dendritic cells differentiated with vitamin D3, dexamethasone and rapamycin. Sci Rep 8, 14985 (2018). https://doi.org/10.1038/s41598-018-33248-7 Available at https://www.nature.com/articles/s41598-018-33248-7
[5] Palacios, C., & Gonzalez, L. (2014). Is vitamin D deficiency a major global public health problem? The Journal of steroid biochemistry and molecular biology, 144 Pt A, 138–145. https://doi.org/10.1016/j.jsbmb.2013.11.003 Available at https://www.intechopen.com/books/a-critical-evaluation-of-vitamin-d-basi...
[6] Lay, C. (13th October 2020). Care homes ‘should give Vitamin D to residents’. The Times. Available at https://www.thetimes.co.uk/article/care-homes-should-give-vitamin-d-to-r...
[7] Williams J, Williams C. (2020). Responsibility for vitamin D supplementation of elderly care home residents in England: falling through the gap between medicine and food. BMJ Nutrition, Prevention & Health 2020;bmjnph-2020-000129. doi: 10.1136/bmjnph-2020-000129 Available at https://nutrition.bmj.com/content/early/2020/09/20/bmjnph-2020-000129
[8] Annweiler, C., Zhijian, C., & Sabatier, J. (June 07, 2020). Point of view: Should COVID-19 patients be supplemented with vitamin D? Maturitas. Review article, Volume 140, P24-26, DOI:https://doi.org/10.1016/j.maturitas.2020.06.003 Available at https://www.maturitas.org/article/S0378-5122(20)30292-9/fulltext
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[11] Yeh R, Valsdottir L, Yeh M, Shen C, Kramer D, et al. PARACHUTE Investigators. (13th December 2018) Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial. BMJ. 2018 Dec 13;363:k5094. doi: 10.1136/bmj.k5094. Erratum in: BMJ. 2018 Dec 18;363:k5343. PMID: 30545967; PMCID: PMC6298200. Available at https://pubmed.ncbi.nlm.nih.gov/30545967/
[12] Entrenas Castillo, M., Entrenas Costa, L., Vaquero Barrios, J., Alcalá Díaz, J., López Miranda, J., Bouillon, R., & Quesada Gomez, J. (29th August 2020). Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study. The Journal of steroid biochemistry and molecular biology, 203, 105751. https://doi.org/10.1016/j.jsbmb.2020.105751 Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/
[13] Ohaegbulam, K., Swalih, M., Patel, P., Smith, M., & Perrin, R. (13th Aug 2020). Vitamin D Supplementation in COVID-19 Patients: A Clinical Case Series. American journal of therapeutics, 27(5), e485–e490. https://doi.org/10.1097/MJT.0000000000001222 Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473790/
[14] Tan, C., Ho, L., Kalimuddin, S., Cherng, B., Teh, Y., et.al. (10th June 2020) A cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients. doi: https://doi.org/10.1101/2020.06.01.20112334 Available at https://www.medrxiv.org/content/10.1101/2020.06.01.20112334v2
[15] Panagiotou, G., Tee, S. A., Ihsan, Y., Athar, W., Marchitelli, G., Kelly, D., Boot, C. S., Stock, N., Macfarlane, J., Martineau, A. R., Burns, G., & Quinton, R. (2020). Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity. Clinical endocrinology, 10.1111/cen.14276. Advance online publication. https://doi.org/10.1111/cen.14276 Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361912/
[16] Arvinte, C., Singh, M. & Marik, P. (18th Sept 2020). Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study. Medicine in Drug Discovery Available online 18 September 2020, 100064 In Press, Uncorrected Proof https://doi.org/10.1016/j.medidd.2020.100064 Available at https://www.sciencedirect.com/science/article/pii/S2590098620300518?via%...
[17] Baktash, V., Hosack, T., Patel, N., et al (27th August 2020). Vitamin D status and outcomes for hospitalised older patients with COVID-19. Postgraduate Medical Journal Published Online First: doi: 10.1136/postgradmedj-2020-138712 Available at https://pmj.bmj.com/content/early/2020/10/06/postgradmedj-2020-138712
[18] Carpagnano, G., Di Lecce, V., Quaranta, N., Zito, A., Buonamico, E., Capozza, E., et al. (Aug 2020). Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. J Endocrinol Invest. 2020 Aug 9:1–7. doi: 10.1007/s40618-020-01370-x. Available at https://pubmed.ncbi.nlm.nih.gov/32772324/
[19] Cunat, T., Ojeda, A., & Calvo, A. (22 May 2020). Vitamin D deficiency in critically ill patients diagnosed with COVID -19. Are we doing enough? A retrospective analysis of 226 patients. Square Research. DOI: 10.21203/rs.3.rs-30390/v1 Available at https://www.researchsquare.com/article/rs-30390/v1
[20] D'Avolio, A., Avataneo, V., Manca, A., Cusato, J., De Nicolò, A., Lucchini, R., Keller, F., & Cantù, M. (May 2020). 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2. Nutrients. 9;12(5):1359. doi: 10.3390/nu12051359. PMID: 32397511; PMCID: PMC7285131. Available at https://pubmed.ncbi.nlm.nih.gov/32397511/
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medRxiv 2020.10.05.20206706; doi: https://doi.org/10.1101/2020.10.05.20206706 Available at https://www.medrxiv.org/content/10.1101/2020.10.05.20206706v1
[23] Fasano, A., Cereda, E., Barichella, M., Cassani, E., Ferri, V., Zecchinelli, L., & Pezzoli G. (Jul 2020) COVID-19 in Parkinson's Disease Patients Living in Lombardy, Italy. Mov Disord. 35(7):1089-1093. doi: 10.1002/mds.28176. Epub 2020 Jun 26. PMID: 32484584; PMCID: PMC7300944. Available From https://pubmed.ncbi.nlm.nih.gov/32484584/
[24] Faul, J., Kerley, C., Love, B., O'Neill, E., Cody, C., et al. (7th May 2020). Vitamin D Deficiency and ARDS after SARS-CoV-2 Infection. Ir Med J. 2020 May 7;113(5):84. PMID: 32603575. Available from https://pubmed.ncbi.nlm.nih.gov/32603575/
[25] Gennari, L., re by Robinson, K. (16th Sept 2020). Vitamin D Deficiency Is Independently Associated with COVID-19 Severity and Mortality. September 11. ASMBR 2020 Annual Meeting Virtual Event. Available at https://www.rheumatologynetwork.com/view/low-vitamin-d-may-worsen-covid-19
[26] Ghasemian, R., Shamshirian, A., Heydari, K., Malekan, M., Alizadeh-Navaei, R., et al. (7th August 2020). The Role of Vitamin D in The Age of COVID-19: A Systematic Review and Meta-Analysis Along with an Ecological Approach. medRxiv 2020.06.05.20123554; doi: https://doi.org/10.1101/2020.06.05.20123554 Available from https://www.medrxiv.org/content/10.1101/2020.06.05.20123554v2
[27] Kaufman, H., Niles, J., Kroll, M., Bi, C., & Holick, M. (17th Sept 2020). SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLoS One. 2020 Sep 17;15(9):e0239252. doi: 10.1371/journal.pone.0239252. PMID: 32941512; PMCID: PMC7498100. Available at https://pubmed.ncbi.nlm.nih.gov/32941512/
[28] Im, H,. Je, Y., Baek, J., Chung, M., Kwon, H., & Lee, J. (11th Aug 2020). Nutritional status of patients with coronavirus disease 2019 (COVID-19), International Journal of Infectious Diseases, 2020, ISSN 1201-9712,
https://doi.org/10.1016/j.ijid.2020.08.018. Available at http://www.sciencedirect.com/science/article/pii/S1201971220306470
[29] Isaia, G. (25th March 2020) Possibile ruolo preventivo e terapeutico della vitamina D nella gestione della pandemia da COVID-19 Università degli Studi di Torino
[30] Israel, A., Cicurel, A., Feldhamer, I., Dror, Y., Giveon, S., et al. (7th Sept 2020) The link between vitamin D deficiency and Covid-19 in a large population. medRxiv 2020.09.04.20188268; doi: https://doi.org/10.1101/2020.09.04.20188268 Available at https://journal.niidi.ru/jofin/article/view/1073/810https://www.medrxiv.... (In Russian)
[31] Karahan, S., Katkat, F. (5th Oct 2020). Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey. J Nutr Health Aging (2020). https://doi.org/10.1007/s12603-020-1479-0 Available at https://link.springer.com/article/10.1007/s12603-020-1479-0
[32] Karonova, T., Andreeva, А., & Vashukova, М. (2020). Serum 25(oH)D level in patients with CoVID-19. Journal Infectology. 2020;12(3):21-27. https://doi.org/10.22625/2072-6732-2020-12-3-21-27 Available at
[33] Kazaryan, A. re by Valera, D., (11th October 2020). UCSF Fresno study explores possible link between COVID-19 and Vitamin D. In the study, the majority of the patients with low Vitamin D levels landed in the ICU. YourCentralValley.com available at https://www.yourcentralvalley.com/news/ucsf-fresno-study-explores-possib...
[34] Lau, F., Majumder, R., Torabi, R., Saeg, F., Hoffman, R., Cirillo, J., & Greiffenstein, P. (28th Apr 2020). Vitamin D Insufficiency is Prevalent in Severe COVID-19 doi: https://doi.org/10.1101/2020.04.24.20075838 Available from https://www.medrxiv.org/content/10.1101/2020.04.24.20075838v1
[35] Macaya, F., Espejo, C., Valls, A., Fernández-Ortiz, A., del Castillo, J., et al. (20th July 2020). Interaction between age and vitamin D deficiency in severe COVID-19 infection. Hospital Clínico San Carlos. IdISSC. Universidad Complutense. Madrid, Spain 10.20960/nh.03193 Available at https://www.nutricionhospitalaria.org/articles/03193/show
[36] Maghbooli, Z., Sahraian, M., Ebrahimi, M., Pazoki, M., Kafan, S., et al. (2020). Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PloS one, 15(9), e0239799. https://doi.org/10.1371/journal.pone.0239799 Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518605/
[37] Mardani, R., Alamdary, A., Mousavi Nasab, S., Gholami, R., Ahmadi, N., & Gholami, A. (2020). Association of vitamin D with the modulation of the disease severity in COVID-19. Virus Res. Aug 28;289:198148. doi: 10.1016/j.virusres.2020.198148. Epub ahead of print. PMID: 32866536; PMCID: PMC7455115. Available from https://pubmed.ncbi.nlm.nih.gov/32866536/
[38] McCartney, D., & Byrne, D. (Apr 2020) Optimisation of Vitamin D Status for Enhanced Immuno-protection Against Covid-19. Ir Med J. 2020 Apr 3;113(4):58. PMID: 32268051. Available from https://pubmed.ncbi.nlm.nih.gov/32268051/
[39] Meltzer, D., Best, T., Zhang, H., Vokes, T., Arora, V., & Solway, J. (2020). Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence. medRxiv : the preprint server for health sciences, 2020.05.08.20095893. https://doi.org/10.1101/2020.05.08.20095893 Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274230/
[40] Mendy, A., Apewokin, S., Wells, A. A., & Morrow, A. L. (2020). Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients. medRxiv : the preprint server for health sciences, 2020.06.25.20137323. https://doi.org/10.1101/2020.06.25.20137323 Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325178/
[41] Merzon, E., Tworowski, D., Gorohovski, A., Vinker, S., Golan Cohen, A., Green, I., & Frenkel-Morgenstern, M. (2020). Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study. The FEBS journal, 10.1111/febs.15495. Advance online publication. https://doi.org/10.1111/febs.15495 Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404739/
[42] Philipose, Z., Smati, N., Wong, C., Aspey., & Mendall, M. (26th Aug 2020). Obesity, old age and frailty are the true risk factors for COVID-19 mortality and not chronic disease or ethnicity in Croydon.
doi: https://doi.org/10.1101/2020.08.12.20156257
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[47] Silberstein, M. (2020). Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role for Vitamin D International Immunopharmacology Volume 88, November 2020, 106995 https://doi.org/10.1016/j.intimp.2020.106995 Available at https://www.sciencedirect.com/science/article/pii/S1567576920328976
[48] Tort, A., Mercado, E., Martínez‑Cuazitl, A., Nieto, A., & Pérez R. (2020). La deficiencia de vitamina D es un factor de riesgo de mortalidad en pacientes con COVID-19. (Deficiency of vitamin D is a risk factor of mortality in patients with COVID-19). Rev Sanid Milit Mex. 2020;74(1-2):. doi:10.35366/93773. Órgano de difusión del Servicio de Sanidad Militar y del Colegio Nacional de Médicos Militares. Available at https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=93773&idP...
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