30/09/2026
We’re delighted to see Cell Xtreme contribute imaging data to new research published in Science Advances.
In the paper “The CENP-A chaperone complex spatially organizes centromeres,” Alexander E. Kelly’s team at the National Institutes of Health (NIH) reveals a previously unrecognized structural role for the CENP-A chaperone machinery.
Led by first author Hindol Gupta, the study shows that during interphase, CENP-A and the CCAN assemble into shell-like structures surrounding a chromatin-poor central cavity occupied by the CENP-A chaperone complex.
As described in the Methods, Hessian 3D-SIM super-resolution images in Fig. 1E were acquired using a Cell Xtreme microscope from CSR Biotech:
The Cell Xtreme data contributed to the imaging evidence revealing the ring-like organization of centromeric structures across different biological systems.
🔗 https://www.science.org/doi/10.1126/sciadv.aef1579
A special historical connection: the term “molecular chaperone” was first introduced by Ron Laskey and colleagues in 1978, in their work on nucleoplasmin and nucleosome assembly.
Nearly five decades later, this study explores the structural role of another chaperone system—the CENP-A chaperone complex—with Hessian 3D-SIM contributing to its visualization.
Ron is also the direct family of our colleague Pete Laskey, making this a particularly meaningful connection for our team.
Congratulations to Alexander E. Kelly, Hindol Gupta, and colleagues on this publication. We’re glad to see Cell Xtreme contributing to research that advances our understanding of the nanoscale organization of the cell.
