30/07/2020
Oxford vaccine shows protection against
COVID-19 in monkeys: Study
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Preliminary results from this research were used
to facilitate the start of clinical trials of the
vaccine in humans, the researchers noted.
A COVID-19 vaccine candidate developed by the
University of Oxford in the UK elicits an immune
response and reduces the viral load in monkeys
exposed to SARS-CoV-2 virus, according to a
study published in the journal Nature on
Thursday.
The researchers from National Institute of
Allergy and Infectious Diseases in the US and
the Oxford University found that the ChAdOx1
nCoV-19 vaccine protects the macaques from
COVID-19 pneumonia â a complication of SARS-
CoV-2 infection in which the lungs become
inflamed and may fill with fluid.
Preliminary results from this research were used
to facilitate the start of clinical trials of the
vaccine in humans, the researchers noted.
ChAdOx1 nCoV-19 is made from a weakened
chimpanzee adenovirus â a group of viruses that
can cause a range of illnesses, including the
common cold â that expresses the SARS-CoV-2
spike protein, a structure that enables the
coronavirus to enter human cells.
The researchers show that a single dose of
ChAdOx1 nCoV-19, given to six macaques 28
days before exposure to SARS-CoV-2, is
effective in preventing damage to lungs and
drastically reduces the viral load, when
compared with six control animals.
A further six macaques were given a booster
course of two doses of the vaccine, at 56 and
28 days before challenge, which increased the
immune response, the team found.
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