Neuroservices-Alliance

14/05/2026

When you need to understand how neurons communicate — not just how they fire individually — HD-MEA is the answer.

Our High-Density Multi-Electrode Array platform — powered by Maxwell Biosystems MaxTwo — records from hundreds of electrodes simultaneously, capturing spontaneous and evoked network activity across an entire neuronal population.

This means you get:

→ Burst frequency & synchrony
→ Network-level drug effects
→ High-throughput screening capacity
→ Data that reflects how neurons actually communicate

A more complete picture of your compound's effect on the CNS.

https://www.neuroservices-alliance.com/high-density-mea/

14/05/2026

Some things you can't replicate in a dish.

Acute brain slice electrophysiology keeps neurons in their native environment — intact local circuits, preserved synaptic connections, real tissue architecture. That's what makes it one of the most physiologically relevant platforms in CNS research.

In our brain slice lab, we record from living tissue to measure:

→ Synaptic transmission & plasticity (LTP/LTD) → Network excitability → Drug effects on native circuits

When your compound needs to prove it works in context — not just on isolated cells — brain slice gives you that answer.

🔗 www.neuroservices-alliance.com

14/05/2026

Some questions in CNS and pain research require more than just knowing whether a compound binds — you need to see how neurons actually respond. 🔬

Calcium imaging makes that possible. By tracking dynamic changes in intracellular calcium levels, this technique provides a direct readout of neuronal activity — at both the single-cell and population level.

When combined with our patch clamp and HD-MEA platforms, calcium imaging becomes part of a multi-endpoint strategy that gives your program the functional data it needs to move forward with confidence.

🔗 Learn more about our calcium imaging capabilities: https://www.neuroservices-alliance.com/calcium-imaging

14/05/2026

At Neuroservices-Alliance, our strength comes from the depth and complementarity of our expertise. A dedicated team of neuroscientists, each a recognized expert in their field, working together to deliver functional data that drives real decisions in CNS and pain drug discovery.

From human iPSC-derived neurons to in vivo brain recordings. From brain slices to behavioral models. Across rodent, non-human primate, and human tissues. Across five expert platforms. Across two continents.

The same standard. Every study. Every time.

🔗 Learn more about us: https://www.neuroservices-alliance.com/about-us/

14/05/2026

Not every drug discovery program starts with a compound. Sometimes it starts with a question: does this gene mutation actually change how neurons function?

This is exactly the type of study Neuroservices-Alliance is designed to support. Using client-provided iPSC-derived neurons — motor neurons and cortical neurons — our cell electrophysiology team applies whole-cell patch clamp recordings to functionally characterize disease phenotypes in CRISPR-engineered models.

By comparing isogenic wild-type controls against knock-out lines, we can detect whether a genetic loss-of-function translates into measurable changes in neuronal excitability — including resting membrane potential, action potential threshold, firing frequency, and more.

This approach is particularly powerful for rare neurological disease research, where iPSC models derived from patient cells or engineered cell lines offer the only human-relevant window into disease mechanisms.

If you have a disease model and a scientific question — we can help design the functional assay around it.

🔗 Learn more about our cell electrophysiology platform: https://www.neuroservices-alliance.com/experts-platform/cell-electrophysiology/

14/05/2026

Synaptic plasticity isn't just a mechanism — it's a therapeutic target. 🧠

Plastogens like ketamine produce rapid antidepressant effects by promoting synaptogenesis and restoring synaptic connectivity. But characterizing these effects requires assays that go beyond receptor-level pharmacology.

At Neuroservices-Alliance, we developed a paired assay framework in our brain slice laboratory to capture both dimensions of plasticity:

🔗 Read the full assay here: https://www.neuroservices-alliance.com/assaying-synaptic-plasticity-in-brain-slices-paired-patch-cla...

14/05/2026

Proud to have played a role in research that just made it to the pages of Nature. 🔬

Scientists at The Scripps Research Institute, achieved the scalable total synthesis of saxitoxin and related natural products — powerful sodium channel blockers with major implications for pain research and neuropharmacology.

To validate the functional activity of these compounds, the Scripps team turned to Neuroservices-Alliance. Our San Diego cell electrophysiology team provided patch-clamp recordings from dorsal root ganglion (DRG) sensory neurons — confirming sodium channel blocking activity at the cellular level and supporting the translational relevance of the synthesized compounds.

🔗 Read more about the collaboration on our blog: https://www.neuroservices-alliance.com/from-natures-toxins-to-the-pages-of-nature-supporting-neurotoxin-research-at-scripps/ and read the full article here : https://www.nature.com/articles/s41586-025-09551-5

14/05/2026

Pain is one of the hardest areas to crack in drug discovery — and a big reason is that the neurons responsible for pain signaling are often underrepresented in preclinical models.

Dorsal Root Ganglion (DRG) sensory neurons are where peripheral pain signaling begins. Recording directly from these cells gives researchers a functional window into pain pathways that no other model can provide.

At Neuroservices-Alliance, our cell electrophysiology platform offers recordings from DRG sensory neurons across multiple species — including rodent, canine, and non-human primates — supporting target validation and compound profiling in pain drug discovery.

🔗 Schedule a meeting with our scientists to discuss your drug discovery program https://www.neuroservices-alliance.com/contact/

14/05/2026

Human neurons. Functional data. Translational relevance.

iPSC-derived neurons offer something traditional cell models can't: a human cellular context for studying how compounds affect neuronal activity — without the variability of primary tissue.

At our San Diego cell electrophysiology lab, we use human iPSC-derived neurons in combination with patch clamp and high-density MEA recordings to generate functional data that supports CNS and pain drug discovery programs.

🔗 Read our latest blog post on the functional properties of human NGN2 neurons: https://www.neuroservices-alliance.com/electrophysiological-profiling-the-functional-properties-of-human-ngn2-neurons/

14/05/2026

Knowing a compound binds to a target is a starting point — not a conclusion.

Target engagement validation answers the question that really matters in drug discovery: does your compound actually change how neurons function? Binding data alone can't tell you that. Functional data can.

Electrophysiology is one of the most direct ways to measure target engagement at the neuronal level. ⚡

At Neuroservices-Alliance, our platforms provide the functional endpoints your program needs to make confident go/no-go decisions in CNS and pain research.

Process-dependent. Reproducible. Built for decision-making.

🔗 Learn more about our electrophysiology platforms: www.neuroservices-alliance.com

Neuroservices-Alliance accelerates CNS drug discovery with expert electrophysiology and neuropharmacology services. Your trusted CRO partner.