Centre for Translational Stem Cell Biology 幹細胞轉化研究中心

Centre for Translational Stem Cell Biology 幹細胞轉化研究中心 Centre for Translational Stem Cell Biology (CTSCB) aims to invigorate industries in regenerative medicine, organ transplantation and genomic medicine

25/09/2026

Happy Mid-Autumn Festival!🌕🥮

Centre for Translational Stem Cell Biology 幹細胞轉化研究中心 wishes you and your loved ones joy, good health, and many precious moments as you celebrate beneath the full moon.

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We extend our congratulations to Senior Post-Doctoral Fellow Dr. Xueyan Liu and the collaborative research team on their...
29/07/2026

We extend our congratulations to Senior Post-Doctoral Fellow Dr. Xueyan Liu and the collaborative research team on their recent publication in Allergy (EAACI). Led by Dr. Xueyan Liu, Prof. Pengtao Liu, Prof. CS Lau, Prof. Matthew Cook, Prof. Philip Li, this work highlights the strength of our collective research efforts between the Centre for Translational Stem Cell Biology (CTSCB) and HKU Medicine .

The paper, "Modelling Hereditary Angioedema With Personalised EPSC‐Derived Hepatocytes: A CRISPR-Validated Platform for Mutation-Specific Mechanisms and Therapeutic Innovation," presents a patient-specific stem cell model for Hereditary Angioedema (HAE), advancing precision medicine.

💡 Key Highlights of the Study:

Personalized Liver Model: Using Expanded Potential Stem Cells (EPSCs) derived from HAE patient blood cells, the team successfully generated functional hepatocyte-like cells (HLCs) that recapitulate physiological C1 esterase inhibitor (C1INH) production and secretion.

Uncovering Mutation-Specific Mechanisms: The study demonstrated how distinct SERPING1 mutations drive disease variability at the cellular level.

CRISPR Precision Repair: Utilizing CRISPR/Cas9 genome editing, the team repaired patient mutations to successfully restore normal C1INH secretion, confirming disease causality and proving the potential for targeted genetic strategies.

This research establishes a robust, scalable human model for rare inherited liver and immune disorders, supporting innovation in precision gene-targeted therapies.

Read the full publication here: https://onlinelibrary.wiley.com/doi/10.1111/all.70419?af=R

👉Follow Centre for Translational Stem Cell Biology 幹細胞轉化研究中心 and stay tuned for more updates.

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29/07/2026

【重症解密】港大醫學院教授現身說法 介紹重症診治過程及治療方法

TVB製作的全新醫學節目《重症解密》，節目組邀請了多位港大醫學院教授來探討肝癌、原發性免疫缺乏症、心臟病、青光眼、脊髓型頸椎病變、阿茲海默症、乳癌等重症病因、症狀及治療方法。節目將於星期一至五，晚上9時30分播放。

7月28日 - 肝癌

外科學系臨床教授陳智仁教授、臨床腫瘤學系蔣子樑醫生將介紹肝癌治療新技術，包括了先縮後除LRT-IO療法。外科學系講座教授萬鈞教授亦會介紹「肝立方」如何為肝癌病人提供最佳治療方案。

節目連結：https://www.youtube.com/watch?v=Bn8O-pEacU0

7月30日- 原發性免疫缺乏症

港大醫學院院長劉澤星教授及內科學系臨床副教授李曦醫生將會介紹個人化幹細胞治療如何幫助原發性免疫缺乏症患者。這是港大醫學院、InnoHK幹細胞轉化研究中心和劍橋大學共同開創一個新型幹細胞平台，應用於個人化治療罕見免疫缺陷病，為患者提供新的治療選擇。

節目連結：https://www.youtube.com/watch?v=fy2jjK-axEs

8月3日 - 心臟病

內科學系臨床教授姚啟恒教授將解釋解構急性心肌梗塞的迷思，以及介紹嶄新影像技術caFFR 系統如何讓醫生更精準判斷血管阻塞情況及真正導致缺血的原因。

節目連結：https://youtu.be/yWC1ZCHc66g?si=V0jjvUn8D8aGnVhF

8月5日 - 青光眼

眼科學系系主任及臨床教授梁啟信教授將會解構青光眼成因及治療方式，及介紹新技術視網膜神經纖維層光學紋理分析 （ROTA）如何將透過人工智能來協助醫生診斷及有系统地為青光眼患者進行疾病管理。

節目連結：https://youtu.be/MuFaudFDvc0?si=g8SCYmbSp4K0_IGW

8月7日 - 脊髓型頸椎病變

矯形及創傷外科學系臨床副教授關日康醫生解構脊髓型頸椎病變成因及如何診斷，及介紹新式手術 - 預防性減壓手術

節目連結：https://youtu.be/fTohTce5uBE?si=C5h8zxpdZik7_f9p

8月9日 - 阿茲海默症

內科學系臨床教授陳灌豪教授、內科學系名譽臨床副教授佘日峯醫生、放射診斷學系臨床副教授麥嘉豐醫生、精神醫學系臨床助理教授鄭柏榮醫生將解構認知障礙症成因及治療方式，亦會介紹非入侵性腦電擊及類澱粉蛋白正電子掃描等技術。

節目連結：https://youtu.be/8QOUyV7hUQ8?si=fsnNgj1nt_gb1wQ1

8月10日 - 乳癌

外科學系臨床教授鄺靄慧教授拆解乳癌分類與成因及治療方式，並介紹冷凍細胞技術及自體脂肪移植技術如何幫助乳癌患者。

節目連結：https://youtu.be/6GEVtSAdizM?si=Pl05U4-P-qDhIvZo

大家密切留意！

節目網站：https://programme.tvb.com/tc/severecasedecoded_146823/%E9%87%8D%E7%97%87%E8%A7%A3%E5%AF%86

#港大醫學院

⭐Highlights from ASGH 2026Centre for Translational Stem Cell Biology 幹細胞轉化研究中心 was delighted to present our diverse tran...
15/05/2026

⭐Highlights from ASGH 2026

Centre for Translational Stem Cell Biology 幹細胞轉化研究中心 was delighted to present our diverse translational research portfolio and showcase cutting-edge EPSC technology at ASGH. Our innovative platforms are designed to address some of the most pressing health challenges—including infectious, inflammatory, autoimmune, neurological, cardiovascular, immune, and age-related conditions.

We are proud to have established 8 spin-off companies that turn breakthroughs into real-world innovation. At ASGH, we highlighted 3 of these ventures:

1. Estelle Biovita: Developing innovative skincare solutions powered by proprietary bioactive ingredients and cutting-edge stem cell technology.

2. Synhealer: Advancing immunotherapies for solid tumours using Antibody-CAR-Macrophage (AB-CAR-M) technology, with a primary focus on liver cancer.

3. NexusAb: Establishing a transgenic mouse platform for in vivo discovery of therapeutic single domain antibodies (VHHs).

Thank you to everyone who visited our booth, met our team, and contributed to the conversations around advancing stem cell science. We look forward to building new collaborations and accelerating progress together.

👉 Follow Centre for Translational Stem Cell Biology 幹細胞轉化研究中心 for more updates on our research and innovations.

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Dr. Timothy Tam, Postdoctoral Fellow in Prof. Pengtao Liu’s Lab, in collaboration with Prof. Guojun Sheng from Kumamoto ...
17/04/2026

Dr. Timothy Tam, Postdoctoral Fellow in Prof. Pengtao Liu’s Lab, in collaboration with Prof. Guojun Sheng from Kumamoto University, has led a review article now published in Nature Cell Biology — “Amniogenesis in embryos and stem cell models.”

The work explores the mechanisms underlying amniotic formation and how cutting-edge stem cell-based human embryo models are advancing our understanding of one of the earliest and most critical stages of human development.

Read the full article:
https://www.nature.com/articles/s41556-026-01873-4

Congratulations to Dr. Tam, Prof. Pengtao Liu, and all co-authors! 👏

👉Follow Centre for Translational Stem Cell Biology 幹細胞轉化研究中心 and stay tuned for more updates.

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Engineered SOX17 and miniSOX not only replace but outperform SOX2 in driving efficient mouse and human iPSC generation. ...
14/04/2026

Engineered SOX17 and miniSOX not only replace but outperform SOX2 in driving efficient mouse and human iPSC generation. In a new study led by Dr. Haoqing Hu from Prof. Ralf Jauch’s lab, with key contributions from Martha Yeung, Yuebin Tan and Dr. Degong Ruan, we now show that these engineered SOX factors also enable the robust derivation of induced Expanded Potential Stem Cells (iEPSCs) – the key translational stem cell platform of the Centre for Translational Stem Cell Biology 幹細胞轉化研究中心 for modelling early development and discovering new antiviral and anti‑aging therapies.

Read the full paper: https://www.nature.com/articles/s42003-026-09963-7

A huge congratulations to Dr. Haoqing Hu and the entire team for this outstanding work. 🎉

👉Excited to see where this research leads — follow Centre for Translational Stem Cell Biology 幹細胞轉化研究中心 for more updates.

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