OPFE Holding

15/06/2026

COPRICOM™ EXTRA – WHEN HORMONE IMBALANCE IS NOT DUE TO OVARIES

Some women may seem healthy, not overeating, but still experience irregular periods, acne breakouts, fatigue, and difficulty losing weight despite trying. In many cases, the problem isn't with the ovaries or uterus, but stems from metabolic imbalances, abnormal sensitivity to blood sugar and insulin.

You might think eating less sweets and bubble tea won't affect you? The truth is, the body doesn't differentiate between "more" or "less" – it cares about how many times you consume sugar throughout the day. Each time you eat sugar, your body releases insulin to process it. When this happens repeatedly every day, insulin levels remain consistently high, leading to a condition called "insulin resistance" – a silent cause of disrupted menstrual cycles, difficulty ovulating, acne, weight gain, and persistent fatigue.

CopriCOM™ Extra is designed as a comprehensive solution for these insidious disorders. Instead of vaguely supplementing hormones or herbs, this formula targets the root cause: improving insulin response, stabilizing blood sugar, and restoring the metabolic-endocrine axis.

Each CopriCOM™ Extra tablet contains a combination of seven carefully researched ingredients. Coprinus Comatus mushroom extract provides gentle blood sugar regulation and anti-inflammatory effects, supporting a healthy metabolic environment. Gymnema leaf with standardized gymnemic acid helps reduce sugar absorption and regulate sugar cravings – crucial for those who frequently consume sweets without realizing it. Alpha-lipoic acid – an endogenous antioxidant – plays a vital role in increasing insulin sensitivity, thereby helping the body metabolize sugar into energy more efficiently, rather than storing it as fat. Corosolic acid from Banaba leaves and polyphenol-rich cinnamon extract help stabilize blood sugar and improve glucose metabolism. Chromium Picolinate supports increased insulin sensitivity, while Piperine enhances the bioavailability of the entire formula, ensuring the active ingredients are effective even at low doses.

In addition to controlling blood sugar, these components also help soothe the neuroendocrine-metabolic axis. When insulin is controlled, the brain is no longer overloaded with signals, and the hypothalamus-pituitary-ovarian axis can return to its natural regulatory rhythm. Many women have reported significant improvements after using CopriCOM™ Extra: more regular periods, reduced cravings for sweets, improved mental alertness, and easier weight management without excessive self-straining.

CopriCOM™ Extra is not only for people with diabetes but is also suitable for women with menstrual irregularities, PCOS, abdominal weight gain, or those preparing for pregnancy who need hormonal balance. This product is also very helpful for those on low-carb or low-GI diets who still experience energy dips or unusual cravings.
Not all hormonal imbalances require hormones to fix. Often, simply adjusting the body's response to sugar will allow the cycle to self-regulate. And when hormones are stable, fertility, body shape, and mood will naturally recover.

CopriCOM™ Extra is a product researched and manufactured in Europe under the quality control of OPFE. It's not a magic pill, but an intelligent biological tool to bring your body back to its original state – where metabolism, hormones, and energy function harmoniously as they should.

📱Hotline: +36 20 238 4126 |+36 70 675 2707
🌍Website: https://opfe.eu

04/06/2026

🌺CordySIN: THE RESULT OF DEDICATED DEVELOPMENT🌺

It can be affirmed that CordySIN extra Tibetan Cordyceps is the outstanding result of the tireless efforts of our Hungarian expert team. Building upon the high-quality, trusted, and established CorsyMAX 10x high-dose Tibetan Cordyceps product line, combined with our dedication and vision of "For a healthier world from nature," we have continuously researched to improve quality and reduce costs, aiming to bring even greater benefits to our customers.

CordySIN extra Tibetan Cordyceps boasts many advantages, including the use of vegan capsule shells, 100% gluten-free and lactose-free ingredients, no GMOs, and suitability for vegetarians. In addition, CordySIN surpasses similar products on the market in the following aspects:

1. Highest Polysaccharide content on the market: up to 40%
Polysaccharide is the main component contributing to the pharmacological properties or value of Tibetan Cordyceps Sinensis. The higher the Polysaccharide content, the higher the product quality.

2. Highest amount of Cordyceps Sinensis active ingredient: 395 mg/tablet
While CorsyMAX 10x previously had the highest amount of Cordyceps Sinensis active ingredient compared to similar products, at 339 mg/tablet (Net weight: 455 mg/tablet), each CordySIN extra tablet contains even more, up to 395 mg/tablet (Net weight: 606 mg/tablet, a 33% increase in total active ingredient).

3. Suitable and Valuable High-Quality Excipients
Besides the main ingredients that create the primary function of the product, the excipients are also an important factor in enhancing product quality. CordySIN uses suitable and valuable high-quality excipients such as: Tongkat Ali 200:1, Astragalus 40% Polysaccharide, Ginseng 20% ​​ginsenosidel, Grape seed 80% polyphenol, Coenzyme Q10 98%, L-arginine 98%, Piperine 98%,
With the above-mentioned outstanding advantages, customers can use the maintenance dose to regulate the immune system, enhance libido, etc.

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📱Hotline: +36 20 238 4126 | +36 70 675 2707
🌍Website: https://opfe.eu

29/05/2026

Don't Be Deceived by the "NR" in Advertisements.

The current anti-aging market is flooded with products talking about NR, NAD+, Sirtuin, cell rejuvenation, and reversing aging.
It sounds very scientific.

But consumers need to understand one simple thing:
Not all NR products are valuable.
What matters is whether the daily NR dosage is sufficient.

In many studies, NR is typically used at levels ranging from 100 mg, 300 mg to 1,000 mg/day. Of these, 300 mg/day is a commonly mentioned benchmark when discussing NAD+ enhancement.

Therefore, if a product heavily advertises its NR anti-aging properties, but the actual dosage is modest, consumers should question:
Is this a formula focused on NR, or just a formula with added NR for marketing purposes?

The real concern isn't the low dosage. The worrying thing is that the dosage is disproportionate, but the advertising is exaggerated, leading buyers to believe they are using a powerful formula.
When choosing a NAD+ supplement, look at these three points:
1. How many mg of the main active ingredient are provided daily?

2. Is the formula transparent?

3. Does the advertising exaggerate compared to the ingredient list?
For us, when talking about NAD+, we must first speak with clear numbers.
OriNMN+ Anti-aging combines:
NMN 300 mg + NR Chloride 250 mg
Two important precursors that support the NAD+ production process, aiming for cellular energy and health over time.

We don't choose to sell with promises of "reversing aging" that sound like magic.

We choose a more transparent approach:
Clear formula.
Clear dosage.
Consumers judge for themselves.

Before buying any NAD+ product, do one very simple thing:
Read the ingredient list. Calculate the actual amounts. Then decide.

26/05/2026

🍄 LION'S MANE MUSHROOM – A NATURAL ENERGY SOURCE TO REDUCE ANXIETY AND MILD DEPRESSION

In modern life, anxiety and mild depression have become common problems, affecting hundreds of millions of people worldwide. Statistics show that up to 30% of adults in developing countries have experienced symptoms of anxiety or depression. Prolonged stress, hormonal imbalances, and especially chronic inflammation in the body can contribute to a gloomy and heavy mood.

Fortunately, nature has bestowed upon us a special mushroom – Lion's Mane mushroom (Hericium erinaceus) – with the ability to support improved mood. Preclinical studies show that extracts from this mushroom have neuro-inflammatory effects, helping to reduce symptoms of anxiety and depression in animals. Simultaneously, lion's mane mushroom stimulates nerve cell regeneration and improves hippocampal function – the area that processes memories and emotions. This improved hippocampal activity is believed to be key to alleviating anxiety and depressive behaviors.

Not only in animal studies, a small trial in menopausal women also noted that after just one month of daily lion's mane mushroom supplementation, self-reported irritability and anxiety levels significantly decreased. This opens up prospects for Lion's Mane to become a natural and safe solution for those wishing to balance their mood and find inner peace.

Based on this scientific foundation, we have developed LionsMUS™ – a supplement containing pure, standardized lion's mane mushroom extract, formulated with advanced technology to optimize absorption. LionsMUS™ not only protects memory, but also supports improved mental well-being, helping to reduce mild stress and anxiety and bringing peace of mind.

👉 Let LionsMUS™ be your companion to help you maintain your spirits, find balance, and live more fully each day.

📱Hotline: +36 20 238 4126 |+36 70 675 2707
🌍Website: https://opfe.eu

09/05/2026

Ünnepelek: ez az 5. évem a Facebookon. Köszönöm a folyamatos támogatást. Nélkületek soha nem jutottam volna el idáig. 🙏🤗🎉

12/03/2026

Antrodia cinnamomea – A Hidden Treasure from Taiwan’s Forests

Deep within Taiwan’s ancient forests grows a rare medicinal mushroom known as Antrodia cinnamomea. For generations, it has been valued by local communities as a precious natural remedy.

This mushroom grows exclusively on the tree Cinnamomum kanehirai, which makes its natural occurrence extremely rare. Modern research has identified bioactive compounds such as triterpenoids and polysaccharides, which are being studied for their potential antioxidant, liver-protective, and immune-supporting effects.

From a traditional forest remedy, Antrodia cinnamomea has now become a subject of growing interest in the fields of medicinal mushroom research and natural health science.

Source: https://antrodicin.com

https://youtube.com/shorts/p56yO_Pu--g?si=i_03UGbiHXN-1Gui

Antrodia Cinnamomea is considered "Taiwan's National Treasure", is the most precious fungus in the world, has a price higher than gold, and is listed in the ...

09/03/2026

Why are scientists increasingly interested in NMN?

Inside every cell in our body is a critical molecule called NAD+, which plays a key role in cellular energy production, DNA repair, and the activation of longevity-related enzymes. However, NAD+ levels naturally decline as we age.

NMN (Nicotinamide Mononucleotide) is a direct precursor to NAD+, helping the body restore its levels and support cellular metabolism. By boosting NAD+, NMN may also help activate important longevity proteins known as sirtuins, which are associated with healthy aging.

Clinical research in adults aged 40–65 has shown that NMN supplementation for 60 days can increase the NAD+/NADH ratio by up to 38%, along with improvements in physical endurance and overall wellness indicators.

OriNMN is formulated with high-purity NMN (over 99%), combined with longevity-supporting compounds such as Resveratrol and Spermidine, designed to support cellular health and promote healthy aging.

💕 True wellness starts where aging begins — inside your cells.

“Dietary supplement capsules with herbal extracts containing active ingredients that are used for anti-aging and beauty.”Uthever® NMN, NR is the product with...

24/02/2026

THE ARCHITECTURE OF LONGEVITY

👉 Why do some people remain healthy at 60, while others are already exhausted?

Have you ever wondered:
Why do some people, even after turning 60, still walk quickly, stay mentally sharp, and work tirelessly…

While others, just past 50, already experience:

* Morning fatigue
* Joint pain
* High cholesterol, high blood pressure, diabetes
* And begin living with daily medication?

We often assume it is simply “fate” or “genetics”
👉 But biology does not operate randomly.

The human body does not age at the same rate for everyone.

Inside each of us exists a biological architecture
a system composed of cellular energy, repair capacity, inflammation control, and regeneration.

When this system functions efficiently,
biological aging slows down.

When the system begins to lose efficiency,
disease appears even before we can name it.

Longevity is not about trying to live longer at any cost.

Longevity is about understanding how the body is designed—
and optimizing it before it is too late.

👉 In this series, we will explore together:

* How cells actually create and use energy
* Why inflammation consumes biological age
* Why some people recover quickly while others do not
* And what truly determines the speed of aging

No promises of miracles.

Only a clearer understanding of our own bodies.

If you want to know whether you are moving fast or slow on the journey of aging—
join us in this series.

**The Architecture of Longevity begins here.**

**Next article: Part 1 – Understanding Cellular Energy**

21/11/2025

🧠 Aging & Brain Plasticity: What New Research Reveals

For a long time, many believed that the brain’s ability to change — known as neuroplasticity — declines sharply with age. However, a commentary published in Neural Plasticity challenges this assumption and highlights growing evidence that older adults are still capable of meaningful brain adaptation when learning new skills.
Source: Pauwels, L., Chalavi, S., & Swinnen, S.P. (2018). Aging and Brain Plasticity. Neural Plasticity.
Read the article: https://pmc.ncbi.nlm.nih.gov/articles/PMC6128435/

🔍 Key Insights

Modern brain-imaging studies (MRI, MRS) show that structural and functional changes can still occur in the aging brain during skill learning.

The authors emphasize that training methods matter: more challenging practice schedules — especially random or variable practice — can enhance long-term learning compared to repetitive, predictable (blocked) practice.

Using MR spectroscopy, researchers observed that random training reduces GABA levels in visual brain regions, indicating a temporary release of neural inhibition that supports learning. Interestingly, this effect was even stronger in older adults, showing that their brains respond robustly to challenging training conditions.

In contrast, blocked training was associated with an increase in GABA, suggesting less favorable conditions for neuroplasticity.

💡 Why This Matters

The findings reinforce that neuroplasticity does not end with youth — older adults maintain significant capacity to learn, adapt, and reorganize brain networks.

Designing training environments that are more varied, cognitively demanding, and less repetitive may boost learning potential in older populations.

As global populations age, these insights carry major implications for healthy aging, rehabilitation, and lifelong learning.

📌 Reference

Pauwels, L., Chalavi, S., & Swinnen, S.P. (2018). Aging and Brain Plasticity. Neural Plasticity. https://pmc.ncbi.nlm.nih.gov/articles/PMC6128435/

20/11/2025

CyanthOx™

CyanthOx™ is a high-potency plant extract derived from sea buckthorn (Hippophae) berries cultivated on the Tibetan Plateau. It is standardized to contain rich levels of polyphenols, proanthocyanidins, and bioflavonoids, including quercetin, kaempferol, and isorhamnetin (Puredia, 2024).

Antioxidant Capacity

According to analytical data from Puredia, CyanthOx™ exhibits an exceptionally high ORAC value of 895,281 μmol TE/100 g, surpassing grape seed extract by approximately 9-fold and pine bark extract by roughly 2-fold. This positions CyanthOx™ among the most potent plant-based antioxidant sources currently known.

Stem Cell Activation

A randomized, double-blind, crossover clinical study involving 12 healthy participants demonstrated that consumption of 500 mg/day of CyanthOx™ induced a significant increase in circulating progenitor stem cells, endothelial stem cells, and mesenchymal stromal cells within two hours of ingestion (Drapeau et al., 2019). These findings suggest that CyanthOx™ may support tissue regeneration, vascular health, and intrinsic anti-aging processes.

Mitochondrial and Cellular Energy Effects

In vitro studies using RAW 264.7 macrophage cells exposed to oxidative stress (H₂O₂) showed that CyanthOx™ treatment increased ATP levels by 91%, mitochondrial mass by 69%, and nitric oxide production by 96%. These data indicate strong mitochondrial-protective effects and enhanced cellular bioenergetics (Liu et al., 2022).
Further mechanistic evidence suggests that CyanthOx™ activates the AMPK–PGC-1α–Nrf2 pathway, contributing to mitochondrial biogenesis and reduction of oxidative damage.

Anti-Aging Mechanisms (Three “Keys”)

Puredia describes CyanthOx™ as acting through three major anti-aging mechanisms:

Rejuvenate: Mobilization of circulating stem cells to support tissue repair.

Energize: Enhancement of mitochondrial function and cellular energy production.

Protect: Strong antioxidative defense through neutralization of reactive oxygen species (ROS).

Together, these actions provide a dual protective-and-regenerative biological profile.

Stability and Technological Characteristics

CyanthOx™ is fully water-soluble and exhibits strong stability across temperature and pH ranges. It is produced using patented extraction technologies to preserve bioactive compounds and ensure consistent potency.

Scientific Conclusion

From a scientific perspective, CyanthOx™ represents a highly promising bioactive ingredient for formulations targeting anti-aging, cellular regeneration, mitochondrial health, and long-term physiological resilience. Its combination of powerful antioxidant capacity, stem-cell-mobilizing activity, and mitochondrial support makes it a unique candidate for advanced nutraceutical and functional-health applications.

References

Puredia Corporation Limited. CyanthOx™ – Strongest Plant-based Antioxidant. Puredia, 2024.

Drapeau, C., Benson, K., & Jensen, G. (2019). Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries in healthy human subjects. Clinical Interventions in Aging, 14, 253–263.

Liu, K. et al. (2022). Sea buckthorn proanthocyanidins as protective agents for mitochondrial function in macrophages under oxidative stress. Frontiers in Pharmacology.

Lin, X., Yuen, M. et al. (2022). Regulatory effects of sea-buckthorn procyanidins on oxidative injury in human vascular endothelial cells. Frontiers in Nutrition.