OPFE Holding

12/03/2026

Antrodia cinnamomea – A Hidden Treasure from Taiwan’s Forests

Deep within Taiwan’s ancient forests grows a rare medicinal mushroom known as Antrodia cinnamomea. For generations, it has been valued by local communities as a precious natural remedy.

This mushroom grows exclusively on the tree Cinnamomum kanehirai, which makes its natural occurrence extremely rare. Modern research has identified bioactive compounds such as triterpenoids and polysaccharides, which are being studied for their potential antioxidant, liver-protective, and immune-supporting effects.

From a traditional forest remedy, Antrodia cinnamomea has now become a subject of growing interest in the fields of medicinal mushroom research and natural health science.

Source: https://antrodicin.com

https://youtube.com/shorts/p56yO_Pu--g?si=i_03UGbiHXN-1Gui

Antrodia Cinnamomea is considered "Taiwan's National Treasure", is the most precious fungus in the world, has a price higher than gold, and is listed in the ...

09/03/2026

Why are scientists increasingly interested in NMN?

Inside every cell in our body is a critical molecule called NAD+, which plays a key role in cellular energy production, DNA repair, and the activation of longevity-related enzymes. However, NAD+ levels naturally decline as we age.

NMN (Nicotinamide Mononucleotide) is a direct precursor to NAD+, helping the body restore its levels and support cellular metabolism. By boosting NAD+, NMN may also help activate important longevity proteins known as sirtuins, which are associated with healthy aging.

Clinical research in adults aged 40–65 has shown that NMN supplementation for 60 days can increase the NAD+/NADH ratio by up to 38%, along with improvements in physical endurance and overall wellness indicators.

OriNMN is formulated with high-purity NMN (over 99%), combined with longevity-supporting compounds such as Resveratrol and Spermidine, designed to support cellular health and promote healthy aging.

💕 True wellness starts where aging begins — inside your cells.

“Dietary supplement capsules with herbal extracts containing active ingredients that are used for anti-aging and beauty.”Uthever® NMN, NR is the product with...

24/02/2026

THE ARCHITECTURE OF LONGEVITY

👉 Why do some people remain healthy at 60, while others are already exhausted?

Have you ever wondered:
Why do some people, even after turning 60, still walk quickly, stay mentally sharp, and work tirelessly…

While others, just past 50, already experience:

* Morning fatigue
* Joint pain
* High cholesterol, high blood pressure, diabetes
* And begin living with daily medication?

We often assume it is simply “fate” or “genetics”
👉 But biology does not operate randomly.

The human body does not age at the same rate for everyone.

Inside each of us exists a biological architecture
a system composed of cellular energy, repair capacity, inflammation control, and regeneration.

When this system functions efficiently,
biological aging slows down.

When the system begins to lose efficiency,
disease appears even before we can name it.

Longevity is not about trying to live longer at any cost.

Longevity is about understanding how the body is designed—
and optimizing it before it is too late.

👉 In this series, we will explore together:

* How cells actually create and use energy
* Why inflammation consumes biological age
* Why some people recover quickly while others do not
* And what truly determines the speed of aging

No promises of miracles.

Only a clearer understanding of our own bodies.

If you want to know whether you are moving fast or slow on the journey of aging—
join us in this series.

**The Architecture of Longevity begins here.**

**Next article: Part 1 – Understanding Cellular Energy**

21/11/2025

🧠 Aging & Brain Plasticity: What New Research Reveals

For a long time, many believed that the brain’s ability to change — known as neuroplasticity — declines sharply with age. However, a commentary published in Neural Plasticity challenges this assumption and highlights growing evidence that older adults are still capable of meaningful brain adaptation when learning new skills.
Source: Pauwels, L., Chalavi, S., & Swinnen, S.P. (2018). Aging and Brain Plasticity. Neural Plasticity.
Read the article: https://pmc.ncbi.nlm.nih.gov/articles/PMC6128435/

🔍 Key Insights

Modern brain-imaging studies (MRI, MRS) show that structural and functional changes can still occur in the aging brain during skill learning.

The authors emphasize that training methods matter: more challenging practice schedules — especially random or variable practice — can enhance long-term learning compared to repetitive, predictable (blocked) practice.

Using MR spectroscopy, researchers observed that random training reduces GABA levels in visual brain regions, indicating a temporary release of neural inhibition that supports learning. Interestingly, this effect was even stronger in older adults, showing that their brains respond robustly to challenging training conditions.

In contrast, blocked training was associated with an increase in GABA, suggesting less favorable conditions for neuroplasticity.

💡 Why This Matters

The findings reinforce that neuroplasticity does not end with youth — older adults maintain significant capacity to learn, adapt, and reorganize brain networks.

Designing training environments that are more varied, cognitively demanding, and less repetitive may boost learning potential in older populations.

As global populations age, these insights carry major implications for healthy aging, rehabilitation, and lifelong learning.

📌 Reference

Pauwels, L., Chalavi, S., & Swinnen, S.P. (2018). Aging and Brain Plasticity. Neural Plasticity. https://pmc.ncbi.nlm.nih.gov/articles/PMC6128435/

20/11/2025

CyanthOx™

CyanthOx™ is a high-potency plant extract derived from sea buckthorn (Hippophae) berries cultivated on the Tibetan Plateau. It is standardized to contain rich levels of polyphenols, proanthocyanidins, and bioflavonoids, including quercetin, kaempferol, and isorhamnetin (Puredia, 2024).

Antioxidant Capacity

According to analytical data from Puredia, CyanthOx™ exhibits an exceptionally high ORAC value of 895,281 μmol TE/100 g, surpassing grape seed extract by approximately 9-fold and pine bark extract by roughly 2-fold. This positions CyanthOx™ among the most potent plant-based antioxidant sources currently known.

Stem Cell Activation

A randomized, double-blind, crossover clinical study involving 12 healthy participants demonstrated that consumption of 500 mg/day of CyanthOx™ induced a significant increase in circulating progenitor stem cells, endothelial stem cells, and mesenchymal stromal cells within two hours of ingestion (Drapeau et al., 2019). These findings suggest that CyanthOx™ may support tissue regeneration, vascular health, and intrinsic anti-aging processes.

Mitochondrial and Cellular Energy Effects

In vitro studies using RAW 264.7 macrophage cells exposed to oxidative stress (H₂O₂) showed that CyanthOx™ treatment increased ATP levels by 91%, mitochondrial mass by 69%, and nitric oxide production by 96%. These data indicate strong mitochondrial-protective effects and enhanced cellular bioenergetics (Liu et al., 2022).
Further mechanistic evidence suggests that CyanthOx™ activates the AMPK–PGC-1α–Nrf2 pathway, contributing to mitochondrial biogenesis and reduction of oxidative damage.

Anti-Aging Mechanisms (Three “Keys”)

Puredia describes CyanthOx™ as acting through three major anti-aging mechanisms:

Rejuvenate: Mobilization of circulating stem cells to support tissue repair.

Energize: Enhancement of mitochondrial function and cellular energy production.

Protect: Strong antioxidative defense through neutralization of reactive oxygen species (ROS).

Together, these actions provide a dual protective-and-regenerative biological profile.

Stability and Technological Characteristics

CyanthOx™ is fully water-soluble and exhibits strong stability across temperature and pH ranges. It is produced using patented extraction technologies to preserve bioactive compounds and ensure consistent potency.

Scientific Conclusion

From a scientific perspective, CyanthOx™ represents a highly promising bioactive ingredient for formulations targeting anti-aging, cellular regeneration, mitochondrial health, and long-term physiological resilience. Its combination of powerful antioxidant capacity, stem-cell-mobilizing activity, and mitochondrial support makes it a unique candidate for advanced nutraceutical and functional-health applications.

References

Puredia Corporation Limited. CyanthOx™ – Strongest Plant-based Antioxidant. Puredia, 2024.

Drapeau, C., Benson, K., & Jensen, G. (2019). Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries in healthy human subjects. Clinical Interventions in Aging, 14, 253–263.

Liu, K. et al. (2022). Sea buckthorn proanthocyanidins as protective agents for mitochondrial function in macrophages under oxidative stress. Frontiers in Pharmacology.

Lin, X., Yuen, M. et al. (2022). Regulatory effects of sea-buckthorn procyanidins on oxidative injury in human vascular endothelial cells. Frontiers in Nutrition.

03/11/2025

✅ NMN – Latest Research Update from the Journal of Translational Medicine (2024)

A newly published scientific review in the Journal of Translational Medicine (2024) provides an updated and comprehensive look at NMN — the NAD⁺-boosting molecule gaining major attention in longevity research.

🔍 Key Highlights from the Study:

NMN is confirmed as an essential precursor to NAD⁺, a molecule vital for energy production, DNA repair, and cellular health.

Current research suggests NMN may support metabolic health, liver–gut function, and age-related biological pathways.

Many promising results come from animal studies, showing effects such as reduced inflammation, improved mitochondrial function, and decreased oxidative stress.

Human evidence remains limited, mainly short-term trials using 100–500 mg/day with early but modest benefits.

✅ Why It Matters:

This review shows NMN is a rapidly evolving research field with strong potential for longevity and metabolic support — but larger human clinical trials are still needed to confirm long-term benefits.

📚 Reference:
Advancements in NMN biotherapy and research updates in the field. Journal of Translational Medicine, 2024.
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05614-9

03/11/2025

✅ Cordyceps Sinensis – What Does Modern Science Really Say?

Cordyceps sinensis, often called “winter worm, summer grass,” has been used for centuries in traditional medicine. But what happens when modern research puts this ancient remedy to the test?

🔬 1. Immune System Support

Cordyceps contains active compounds such as cordycepin and polysaccharides, which have been shown to modulate immune function.
✅ Research published in the Journal of Pharmacy and Pharmacology found that Cordyceps extract can increase macrophage and natural killer (NK) cell activity, supporting the body’s natural defense mechanisms.
📚 Reference: Paterson R. (2008). Phytochemistry, 69(7):1469–1495. doi:10.1016/j.phytchem.2008.01.027

💪 2. Improved Energy & Reduced Fatigue

✅ A clinical trial in healthy older adults (2010) found that Cordyceps sinensis increased VO₂ max and improved oxygen utilization, helping reduce exercise-related fatigue.
📚 Reference: Chen S. et al. (2010). Journal of Alternative and Complementary Medicine, 16(5):585–590. doi:10.1089/acm.2009.0308

❤️ 3. Cardiovascular Benefits

Studies suggest Cordyceps may help:

- Lower LDL cholesterol

- Reduce triglycerides

- Protect heart cells from oxidative stress

✅ A review published in the American Journal of Chinese Medicine reported significant improvements in lipid profiles among individuals with high cholesterol.
📚 Reference: Zhu JS, Halpern GM, Jones K. (1998). Am J Chin Med, 26(3–4):281–292.

🫁 4. Respiratory Health Support

Cordyceps has been studied for its potential to ease asthma and inflammation in the airway.
✅ Research shows Cordyceps polysaccharides may reduce airway constriction and inflammation, improving lung function.
📚 Reference: Li SP et al. (2006). Journal of Ethnopharmacology, 105(1–2):136–144.

⚠️ 5. Important Notes

- Wild Cordyceps is extremely rare → most products are cultivated forms (e.g., CS-4), which may differ in potency.

- Not a cure for any disease.

- People on blood thinners, with kidney issues, or preparing for surgery should consult a doctor first.

- Choose reputable brands to avoid contamination or adulteration.

✅ Conclusion

Cordyceps sinensis is a traditional remedy with real scientific evidence supporting its benefits in immunity, fatigue reduction, and cardiovascular and respiratory support.
However, human clinical trials remain limited, and Cordyceps should be viewed as a supportive supplement—not a replacement for medical treatment.

23/10/2025

Spermidine: A Promising Natural Compound in Aging Research

Spermidine, a naturally occurring polyamine found in foods like soybeans, aged cheese, and whole grains, has garnered significant attention in aging research. Recent studies suggest that spermidine may play a crucial role in promoting autophagy, a cellular process that removes damaged components, thereby supporting cellular health and longevity.

Key Findings:

Autophagy Induction: Spermidine has been shown to induce autophagy, a process essential for cellular maintenance and longevity. Research indicates that spermidine levels increase during fasting and caloric restriction, enhancing autophagy and potentially extending lifespan in various organisms, including humans [2].

Human Studies: Epidemiological studies have linked higher dietary intake of spermidine with reduced mortality from cardiovascular diseases and cancer, suggesting its potential benefits in human health [1].

Safety and Tolerability: Clinical trials have demonstrated that supplementation with spermidine is generally safe and well-tolerated in healthy adults, with minimal adverse effects reported [3].

Conclusion:

While preliminary findings are promising, further research, particularly large-scale human clinical trials, is necessary to fully understand the therapeutic potential of spermidine in aging and age-related diseases.

References:

[1] Madeo, F., et al. (2018). Spermidine delays aging in humans. Nature Aging. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC6128428/

[2] Hofer, S. J., et al. (2024). Spermidine is essential for fasting-mediated autophagy and longevity. Nature Cell Biology. Retrieved from https://www.nature.com/articles/s41556-024-01468-x

[3] Keohane, P., et al. (2024). Supplementation of spermidine at 40 mg/day has minimal adverse effects in healthy adults. Food and Chemical Toxicology. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S027153172400126X

This study represents the first investigation into the safety of a novel, high-purity spermidine trihydrochloride supplement (hpSPD) in humans. Spermi…

10/10/2025

🇺🇸 BREAKING: U.S. Allows NMN Sales
In a landmark reversal, the U.S. Food and Drug Administration (FDA) has officially determined that nicotinamide mononucleotide (NMN) may now be lawfully marketed as a dietary supplement.

This decision overturns the previous stance that excluded NMN under the “drug preclusion” rule, marking a major win for both consumers and the supplement industry.

🧬 NMN is a precursor to NAD⁺, a molecule crucial for cellular energy, DNA repair, and healthy aging.
📈 Experts believe this move will have a global impact on the nutraceutical and anti-aging markets.

Sources / References:

NutraIngredients-USA — “FDA declares NMN lawful in dietary supplements”
👉 https://www.nutraingredients-usa.com/Article/2025/09/30/fda-declares-nmn-lawful-in-dietary-supplements

Nutritional Outlook — “FDA responds to citizen petitions on NMN, amending its position on the ingredient’s status as a dietary ingredient”
👉 https://www.nutritionaloutlook.com/view/fda-responds-to-citizen-petitions-on-nmn-amending-its-position-on-the-ingredient-s-status-as-a-dietary-ingredient

NPA (Natural Products Association) — “Amid pressure from NPA, FDA declares NMN lawful in dietary supplements”
👉 https://www.npanational.org/news/amid-pressure-from-npa-fda-declares-nmn-lawful-in-dietary-supplements

After nearly three years of pressure from the NPA, the FDA has reversed course and confirmed that NMN is lawful for use in dietary supplements.

02/06/2025

AstraZeneca Unveils Promising New Breast Cancer Drug

AstraZeneca has announced encouraging results from a Phase III clinical trial of camizestrant, a new oral drug for patients with HR-positive, HER2-negative advanced breast cancer. Presented at the 2025 ASCO meeting, the trial showed that camizestrant, combined with CDK4/6 inhibitors, significantly delayed disease progression—extending progression-free survival to 16 months versus 9.2 months with standard treatment.

The trial also marked the first time a blood test was used to detect ESR1 mutations early, allowing timely treatment adjustments before the cancer progressed visibly. This precision-medicine approach cut the risk of disease progression or death by 56%. Only 1% of patients stopped treatment due to side effects.

AstraZeneca expects camizestrant to generate up to $5 billion annually and is pursuing further studies to broaden its use. This development highlights a major step forward in personalized cancer therapy.

Sources:

Treating breast cancer patients with AstraZeneca's experimental pill camizestrant at the first sign of resistance to standard therapies cut the risk of disease progression or death by half, a finding that could be practice changing, experts said on Sunday.

29/05/2025

**VITAFOODS 2025 – A JOURNEY TOWARDS STRATEGIC PARTNERSHIPS FOR HOLISTIC HEALTH**

We have just concluded three productive days at Vitafoods Europe 2025 – the world’s leading event for ingredients and technologies in the nutraceutical industry.

At this year’s expo, OPFE engaged in several important meetings and achieved two strategic milestones that paved the way for breakthrough developments:

* Secured a high-quality Fucoidan supplier from Australia, extracted from Mozuku seaweed and standardized with ≥40% L-fucose and ≥30% sulfate – meeting pharmaceutical standards and clinically proven to support cancer treatment, enhance immunity, and protect intestinal mucosa.

* Finalized a partnership with a technology provider to develop the OriLipo™ product line, using LipoAvail™ Technology – which enhances the bioavailability of active ingredients by 8 to 107.5 times, delivering truly differentiated efficacy for users.

The first product line-up will include:

* OriLipo™ ONE NAD⁺
* OriLipo™ ONE Curcumin
* OriLipo™ ONE Resveratrol
* OriLipo™ ONE CoQ10
* OriLipo™ ONE Glutathione

Notably, we have signed an exclusive formulation development agreement for a SIRT6 activator product line – a strategic move targeting gene rejuvenation, DNA protection, and activating the body’s natural longevity mechanisms.

This will be one of the pioneering products in Europe to apply a new approach to longevity science and epigenetics.

Vitafoods is not just a place to keep up with trends — it’s where long-term health visions are brought to life through concrete action and meaningful collaboration.

We thank our international partners for taking the time to connect. The journey has only just begun!

01/01/2025