06/06/2013
Position: Group Leader - Discovery Bioanalytical Research and Biotransformation (Code: BMB028)
Qualification: PhD in Analytical Chemistry.
Experience: Minimum of 7 years of professional (industry) experience.
Role:
• The major responsibility of the selected candidate will be to lead the Bioanalytical (BAR) and Biotransformation (BTx) groups within PCO. As a leader of the BAR team, the candidate will be responsible for the development, validation, implementation, and troubleshooting of semiautomatic multiple component analytical methods for the quantitation of drug candidates in biological matrices.
• The candidate will be responsible for providing input into the design of experimental protocols and bioanalytical procedures for the analysis of samples and troubleshooting of methods and instruments, and for the evaluation, interpretation, and distribution of bioanalytical results. As a leader of the BTx team, the candidate will focus on exploratory and definitive metabolite identification studies using mass- and radiolabel-based approaches.
• The candidate should be well-versed with identification of metabolic “soft spots” in new chemical entities and recommend approaches to Medicinal Chemists to modulate metabolic stability. The candidate will represent the department at discovery working group meetings, suggest and implement strategies and tactics to address metabolism and PK-related issues and ultimately enable program decision making in the selection and advancement of high-quality drug candidates into development.
• The incumbent will collaborate with a broad group of scientists in the various PCO departments, and across various disciplines in the Discovery organization. The individual will play a major role in setting group strategy, vision, and take a lead in key scientific initiatives.
Skill Set: The desired candidate should have excellent communication skills and the ability to work in a multi-disciplinary team setting in a fast paced environment. The candidate should have expert knowledge of Bioanalytical Chemistry, Organic Reaction Mechanisms, Separation and Physical Sciences, Mass Spectrometry, and a good knowledge of ADMET and Pharmacokinetic principles. Experience in Bioanalytical quantitation and Metabolite Identification using LC-MS/MS-based methods is required. Demonstrated experience supporting lead optimization programs, and preclinical candidate characterization to enable studies towards regulatory submissions like IND is necessary.
Strong problem solving and leadership skills are required. In addition, excellent interpersonal and communication skills (written and spoken) are mandatory in order to perform in a matrix-team environment. The incumbent should be a strong scientist and be able to manage a group of Ph.D., M.S. and B.S staff.
Location: Bangalore
