21/05/2026
Lipid Changes Happen Hours After Drug Exposure — Before Genes Even Respond. Here's How We Measure Them.
Here's something most drug discovery teams don't track: lipid remodeling.
It happens fast — within hours of drug exposure, well before transcriptional changes. It can reveal how a drug works, flag toxicity risks like phospholipidosis, and uncover resistance mechanisms that genomics alone misses.
Creative Proteomics' Cellular Lipidomics Drug Profiling service is built specifically for this.
What we cover:
🧬 500+ lipid species across 15+ classes. Glycerophospholipids, sphingolipids, sterols, glycerolipids, fatty acids, bioactive lipids — with isomer-level resolution.
🔬 Dual-column LC-MS/MS. HILIC separates by class. RP separates by species. Together they give you the full picture.
🎯 Seven analysis modes. Untargeted discovery, targeted quantification, toxicity screening, cancer vulnerability analysis, signaling lipid profiling, and more.
📊 Drug-tailored experimental design. Dose-response, time course, multiple replicates. Designed for discovery, not just description.
Real example: A 2025 study used this approach to show that FOLFOXIRI-resistant colorectal cancer cells share a common lipid remodeling program across four different cell lines — increased membrane saturation, altered ceramide signaling — that genomic analysis alone could not detect.
Minimum input: 1×10⁶ cells (micro-extraction). Turnaround: 4–6 weeks.
Learn more: creative-proteomics.com/mass-target/cellular-lipidomics-profiling.htm