Nepomics Biotech

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Nepomics Biotech Biotech Company
-Services on Bioinformatics (CADD)
-Research and Development in Biotechnology
www.nepomicsbiotech.com.np

12/10/2026

“Side Chain Refinement in Homology Modeling | Drug Design Tip #68”
Daily Drug Design Tip #68 from Nepomics Biotech. Day 7 of our Homology Modeling series.
Learn how to handle the least reliable parts of a homology model:side chain placement with rotamer libraries, and why binding site residues deserve extra scrutiny.
🔬 Part of our daily series covering Molecular Docking, CADD, QSAR Modeling, ADMET Prediction, Pharmacophore Modeling, Homology Modeling, and Bioinformatics.
🔔 Follow us so you don’t miss tomorrow’s tip.
📍 www.nepomicsbiotech.com.np

11/10/2026

“Loop Modeling in Homology Modeling | Drug Design Tip #67”
Daily Drug Design Tip #67 from Nepomics Biotech. Day 6 of our Homology Modeling series.
Learn how to handle the least reliable part of a homology model: loop modeling (knowledge-based vs ab initio).
🔬 Part of our daily series covering Molecular Docking, CADD, QSAR Modeling, ADMET Prediction, Pharmacophore Modeling, Homology Modeling, and Bioinformatics.
🔔 Follow us so you don’t miss tomorrow’s tip.
📍 www.nepomicsbiotech.com.np

10/10/2026

"Modeller vs SWISS-MODEL vs AlphaFold - Homology Modeling Tools | Drug Design Tip #66"
Daily Drug Design Tip #66 from Nepomics Biotech. Day 5 of our Homology Modeling series.
Compare the main tools for building protein 3D models: Modeller (flexible, spatial-restraint based), SWISS-MODEL (free, automated web server), and AlphaFold (deep learning prediction with per-residue confidence scores). Learn which fits your workflow, and why validation always comes after building.
🔬 Part of our daily series covering Molecular Docking, CADD, QSAR Modeling, ADMET Prediction, Pharmacophore Modeling, Homology Modeling, and Bioinformatics.
🔔 Follow us so you don't miss tomorrow's tip.
📍 www.nepomicsbiotech.com.np

🔴 TOMORROW, LIVE: Finding a Protein's Binding SiteIf you caught our reel, here's the full story, live and unfiltered. 🎙️...
08/10/2026

🔴 TOMORROW, LIVE: Finding a Protein's Binding Site

If you caught our reel, here's the full story, live and unfiltered. 🎙️

Every drug design project starts with one question: where does the ligand actually bind? Get this wrong and everything downstream (docking, MD, optimization) goes with it.

In Nepomics Insights Episode 02, we'll walk you through it step by step:

🔬 Identify the binding site using sequence analysis and prediction tools
🧬 Confirm it with structural modeling
💻 Load the complex in UCSF Chimera and Discovery Studio Visualizer
🎯 Isolate the binding pocket
🔗 Map hydrogen bonds, hydrophobic contacts and key residue interactions in 3D and 2D

Which protein-ligand complex? We're keeping that a surprise until Friday. 👀

📅 Friday, October 9, 2026
⏰ 8-9 PM NPT

▶️ Watch live on YouTube: https://www.youtube.com/
💬 Join and ask questions on Google Meet: https://meet.google.com/kbg-pwcf-mgd

Bring your questions. We'll answer them live.
🔔 Set a reminder and share this with a friend who works in drug discovery!

Part of our weekly series, every Friday, 8-9 PM NPT.

08/10/2026

"Sequence Alignment in Homology Modeling — Target vs Template | Drug Design Tip #65"
Daily Drug Design Tip #65 from Nepomics Biotech. Day 4 of our Homology Modeling series.
Learn why sequence alignment is critical in homology modelling: use proper alignment tools (ClustalW, MUSCLE, T-Coffee), handle gaps and indels correctly, check conserved functional residues, and manually review automated alignments before building your model.
🔬 Part of our daily series covering Molecular Docking, CADD, QSAR Modeling, ADMET Prediction, Pharmacophore Modeling, Homology Modeling, and Bioinformatics.
🔔 Follow us so you don't miss tomorrow's tip.
📍 www.nepomicsbiotech.com.np

07/10/2026

"How to Choose a Template for Homology Modeling — BLAST & Sequence Identity | Drug Design Tip #64"
Daily Drug Design Tip #64 from Nepomics Biotech. Day 3 of our Homology Modeling series.
Learn how to select the right template for homology modeling: using BLAST to search the PDB, checking sequence identity thresholds, evaluating template resolution and structural completeness, and when to use multiple templates.
🔬 Part of our daily series covering Molecular Docking, CADD, QSAR Modeling, ADMET Prediction, Pharmacophore Modeling, Homology Modeling, and Bioinformatics.
🔔 Follow us so you don't miss tomorrow's tip.
📍 www.nepomicsbiotech.com.np

06/10/2026

"When Should You Use Homology Modeling? | Drug Design Tip #63"

Daily Drug Design Tip #63 from Nepomics Biotech. Day 2 of our Homology Modeling series.
Learn the key scenarios for using homology modeling: no experimental structure available, mutant/variant modeling, cross-species targets, and rapid early-stage screening — plus the sequence identity thresholds that determine model reliability.
🔬 Part of our daily series covering Molecular Docking, CADD, QSAR Modeling, ADMET Prediction, Pharmacophore Modeling, Homology Modeling, and Bioinformatics.
🔔 Follow us so you don't miss tomorrow's tip.
📍 www.nepomicsbiotech.com.np

05/10/2026

This week we're doing something new: a live walkthrough of a real protein–ligand complex. 👀

We'll identify the binding site through sequence analysis and prediction tools, confirm it with structural modeling, then break down the ligand's interactions live in UCSF Chimera and Discovery Studio Visualizer.

Which complex? Find out Friday.

🔴 LIVE Friday, 8–9 PM NPT — Nepomics Insights, Ep. 02
📍 Watch live: youtube.com/

Bring your questions.

05/10/2026

"What is Homology Modeling in Drug Design? | Drug Design Tip #62"

Daily Drug Design Tip #62 from Nepomics Biotech. Day 1 of our new Homology Modeling series.
What is homology modeling, and why does it matter when a target protein has no experimentally solved structure? Learn how this technique predicts 3D protein structures from sequence similarity to a known template, enabling structure-based drug design even without a crystal structure.
🔬 Part of our daily series covering Molecular Docking, CADD, QSAR Modeling, ADMET Prediction, Pharmacophore Modeling, Homology Modeling, and Bioinformatics.
🔔 Follow us so you don't miss tomorrow's tip.
📍 www.nepomicsbiotech.com.np

04/10/2026

"Pharmacophore Do's & Don'ts — Validation & Reporting (Series Finale) | Drug Design Tip #61"
Daily Drug Design Tip #61 from Nepomics Biotech. Day 5 — the final day — of our 5-Day Pharmacophore Modeling Do's & Don'ts mini-series.
Learn how to properly validate and report a pharmacophore model: using decoy sets and enrichment analysis, reporting multiple metrics together, documenting full methodology, and treating virtual screening hits as hypotheses rather than confirmed results.
🔬 This wraps our Pharmacophore Modeling series — next, we move into Molecular Dynamics!
🔔 Follow us so you don't miss it.
📍 www.nepomicsbiotech.com.np

Address

Goldhunga, Tarkeshwor/05
Kathmandu
44600

Opening Hours

Monday 09:00 - 17:00
Tuesday 09:00 - 17:00
Wednesday 09:00 - 17:00
Thursday 09:00 - 17:00
Friday 09:00 - 17:00

Telephone

+9779840092026

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