14/06/2022
ALAM MO BA NA DILIKADO ANG PAGKAKAROON NG High Uric Acid?❓❓
PWEDE kasi itong maka Cause ng:
1. High Purine Diet
Uric acid levels majorly get affected by purine-rich foods like beef, organ meats, mussels, sweetbreads, mackerel, spinach, asparagus, beans, lentils, dried peas, etc.
Oxalate-rich foods including spinach, beets, nuts, rhubarb, chocolate, black tea, wheat bran, beans and strawberries also contribute to increased uric acid levels. Some other dietary items like gluten, dairy, corn, white bread, and sugars can also lead to increased uric acid production.
2. Kidney Diseases
Levels of uric acid can also be elevated when the kidneys are unable to eliminate the excess of uric acid from the body. This can majorly be due to kidney dysfunction like kidney stones, chronic kidney disease, adverse effects of some drugs like diuretics, NSAID’s, etc.
3. High Intake of Fructose
Intake of fructose-rich foods and drinks increases the production of inosine and purines, thereby rapidly raising uric acid levels by activating certain enzymes. Fructose also stimulates uric acid synthesis from amino acid precursors such as glycine.
4. Diuretics Elevate Uric Acid Levels
Diuretics are known to be important causes of secondary hyperuricemia. They cause an increase in blood uric acid levels along with an increase in its reabsorption, leading to a decrease in the uric acid secretion from the body.
5. Increased Alcohol Intake
The production of uric acid gets stimulated by alcohol as it increases the lactic acid content in the body, which reduces the excretion of uric acid in the kidney. Alcohol also speeds up the breakdown of purines, thereby raising the production of uric acid.
6. Hypothyroidism
Deficiency of thyroid hormones (T3 and T4) influences the purine metabolism and also causes a reduction in kidney blood flow and filtration rate, which results in elevated uric acid levels in the blood.
7. Obesity
Obesity or excessive body weight leads to the production of excess uric acid in the body, making it difficult for the kidney to process and eliminate it. Hyperuricemia correlates with leptin (hormone that controls hunger) levels, as an obese individual has higher leptin levels (due to leptin resistance).
8. S*x Hormones
Blood uric acid is higher in men as compared to women, making males more prone to hyperuricemia. As estrogen hormone is required for the regular elimination of urate (uric acid salt) through the kidneys, men being low on estrogen tend to develop hyperuricemia.
9. Nutrient deficiency
In menopausal women, hyperuricemia is often linked to a Vitamin D deficiency.
10. High Sodium Intake and Ketogenic Diet
High intake of sodium and following a ketogenic diet (low carb, moderate protein, and high-fat diet) reduces the ability of the kidney to eliminate the uric acid.
11. Parathyroid Hormones
Increase in parathyroid hormone reduces the excretion of urate from the kidney, leading to elevated uric acid levels.
12. Chronic Lead Poisoning
Due to high levels of lead, kidneys the excretion of uric acid, leading to an increased build-up of urate along with uric acid levels.
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