Jakie są godziny otwarcia?

Poniedziałek 09:30 - 19:00 Wtorek 09:30 - 19:00 Środa 09:30 - 19:00 Czwartek 09:30 - 19:00 Piątek 09:30 - 19:00 Sobota 09:30 - 19:00

Structural Biology Core Facility

Name: Structural Biology Core Facility
Address: Gronostajowa 7a, Kraków, 30-387, PL
Telephone: +48126646321

Strona główna
Polska
Kraków
Structural Biology Core Facility

Zadzwoń Wskazówki dojazdu Strona internetowa Kontakt: firmę

We help scientists from Poland and around the world to solve macromolecular structures.

15/09/2026

A synchrotron is a truly special place for us! 🌟
Even though our measurements are currently carried out at various light sources across Europe rather than right here in Kraków, we were thrilled to participate in the Joint Meeting of PSRS Members and Synchrotron SOLARIS Users conference to showcase the capabilities of SBCF.

Our facility was represented by the head of SBCF, dr hab. Piotr Wilk, who presented the broad potential of our research infrastructure in structural biology, success stories, exchanged valuable experiences with the scientific community, and discussed prospects for future collaboration. 🔬

01/09/2026

Every three years, crystallographers from around the world gather for the IUCr Congress International Union of Crystallography Congress. This year, the 27th Congress and General Assembly of the International Union of Crystallography took place in Calgary — and we were thrilled to be part of it!

The event kicked off with satellite workshops focused on contemporary techniques and everyday challenges, followed by seven days of inspiring lectures, discussions, and poster sessions.

We are especially proud that our poster presented by Ela Wątor-Wilk, was selected for a FEBS Open Bio award! Poster entitled "Molecular lockpicks and how to find them. Crystallographic fragment screening campaign against human deoxyhypusine synthase," highlighted a fascinating fragment screening campaign performed in SBCF in collaboration with MAX IV Laboratory.

Thank you to everyone for a fantastic meeting, and we look forward to seeing you at the next IUCr Congress in Berlin in 2029!

09/06/2026

Today, during the MCB Core Facility Review, our Team Leader Piotr Wilk presented a summary of the Structural Biology Core Facility’s activity over the last 6 months, and the sheer volume of work is noticeable. Over this short period, SBCF successfully:

💎 measured 1,120 crystals,
💎 set 371 crystal plates,
💎 completed 8 synchrotron measurement sessions,
💎 supports with our expertise 10 research groups from Małopolskie Centrum Biotechnologii, Wydział Biochemii, Biofizyki i Biotechnologii - Uniwersytet Jagielloński, Wydział Chemii UJ and beyond.

We also successfully executed 2 fragment screening campaigns and celebrated 7 newly published scientific papers that acknowledged the SBCF team for our support.

On top of that, our Vitrobot is back in operation (yet currently only for expert users), and we have officially launched our newest service: Crystallographic Fragment Screening.

Looking to incorporate structural biology or fragment screening into your own research projects? Whether you need support with protein crystallization or structure analysis, feel free to reach out to discuss how we can assist with your project. Let’s solve your next structure together! 🧬✨

# Uniwersytet Jagielloński

29/05/2026

It has been an incredibly busy and successful week for our Structural Biology Core Facility Team.

Our team, led this time by dr Ela Wątor-Wilk, successfully soaked and fished over 800 crystals for our next two consecutive Fragment Screening (FS) campaigns. It was a massive team effort, requiring intense focus, precision, and plenty of coffee. ☕️💎

We would like to extend our gratitude to the team at the MAX IV Laboratory synchrotron especially Tobias Krojer and Afshan Begum (Ph.D.). Your fantastic support, excellent facilities, and technical assistance throughout this run were absolutely vital to our progress.

The work continues as data collection is scheduled to run remotely over the weekend. We are looking forward to analyzing the upcoming results! 💻📈

Małopolskie Centrum Biotechnologii
Uniwersytet Jagielloński

11/05/2026

The results of a successful collaboration between Molecure, the Medical University of Warsaw - MUW, and the Structural Biology Core Facility (SBCF) at Małopolskie Centrum Biotechnologii were recently published in the Journal of Medicinal Chemistry.

While the project was led by Molecure and focused on the discovery and optimization of selective USP7 inhibitors, scientists from SBCF provided critical support through structural analysis using macromolecular crystallography. Their contribution included delivering detailed insights into the binding modes of the inhibitors, which supported the Molecure team in the SAR-driven optimization of the lead compound, OAT-4828.

The research highlights OAT-4828 as a potent inhibitor that enhances T-cell killing capacity and demonstrates significant antileukemic activity in vivo. Furthermore, the study underscores how USP7 inhibition offers a powerful upstream approach to modulating the p53–MDM2 axis.

“It was a pleasure to contribute our facility’s expertise to this high-impact study, illustrating how specialized structural biology services can support innovative drug discovery pipelines,” said dr. hab. Piotr Wilk, Head of the Structural Biology Core Facility at MCB.

Read the full text: https://pubs.acs.org/doi/10.1021/acs.jmedchem.6c00407

$For determining the crystal structure, we need to record an X-ray diffraction pattern from a monocrystal. This implies t...$

13/04/2026

For determining the crystal structure, we need to record an X-ray diffraction pattern from a monocrystal. This implies the need to harvest each crystal individually. We call it fishing, but our prey is so tiny that we need to use a microscope and special, so-called cryo loops and magnetic wands.

Depending on crystal morphology and size, the process may be relatively easy or quite challenging. For the upcoming beamtime, our scientists have fished 201 crystals.

Regardless, the real beauty comes from the crystals' interior revealed to us by the power of macromolecular crystallography, this time during remote measurements at Synchrotron Grenoble.

Małopolskie Centrum Biotechnologii Uniwersytet Jagielloński

02/04/2026

Hello from the synchrotron! 🧬 🔬 💎

Using photons during last shift available before Easter break we are collecting >120 crystals at our favourite beamline: MX beamlines at HZB in Berlin.

With this SBCF accounts for over 10k analysed crystals since 2019.

And as per usual we brought new Xtal enthusiasts along to show them magic which happens at BESSY.

23/03/2026

Last Friday, Prof. Zygmunt Derewenda from the University of Virginia visited the Małopolskie Centrum Biotechnologii to deliver an inspiring lecture on the 200-year history of haemoglobin research.

For those of us at the Structural Biology Core Facility, it was a fascinating deep dive into the roots of our field, tracing the evolution of protein crystallography from the first crystals in 1840 to the pioneering X-ray studies of Max Perutz. Drawing from his own landmark structural work published in Nature, Prof. Derewenda reminded us that while our tools have evolved, the progress of science still relies on interdisciplinary interplay and serendipity.

Uniwersytet Jagielloński

18/03/2026

Yesterday we shared some final results, but today it’s all about the early stages. At SBCF, we help build scientific stories by supporting projects from the very beginning.

For this target, we were involved in every step: from consulting on the project idea and designing the genetic construct, to protein purification and setting up first crystallization screens.

It’s great to see the first crystals appearing after just a few days. We are very curious to see what mystery they hide inside, and we’ll find out in just two weeks during our synchrotron measurements.

If you have a project idea that requires structural insights, we are here to help you navigate the path from gene to structure.

Małopolskie Centrum Biotechnologii Uniwersytet Jagielloński

Adres

Gronostajowa 7a
Kraków
30-387

Godziny otwarcia

Poniedziałek	09:30 - 19:00
Wtorek	09:30 - 19:00
Środa	09:30 - 19:00
Czwartek	09:30 - 19:00
Piątek	09:30 - 19:00
Sobota	09:30 - 19:00

Telefon

+48126646321

Strona internetowa

http://structuralbiology.pl/

Powiadomienia

Bądź na bieżąco: wyślemy Ci e-mail, gdy Structural Biology Core Facility opublikuje nowości i promocje. Twój adres e-mail nie zostanie wykorzystany do żadnego innego celu, a subskrypcję możesz anulować w dowolnym momencie.