28/05/2026
PGC-1α plays a central role in mitochondrial biogenesis and metabolic regulation through complex upstream signaling pathways and downstream transcriptional networks.
In this post, we highlight:
🔸 The PGC-1α → NRF1 → TFAM axis links energy sensing to mitochondrial biogenesis through coordinated mtDNA transcription and replication.
🔸Upstream activators of PGC-1α, including AMPK, SIRT1, and p38
🔸Transcription factors coactivated by PGC-1α, such as NRF1/2, ERRα, ERRγ, PPARγ, and FOXO1
🔗 Explore antibodies for the PGC-1α pathway on our official website:
https://lnkd.in/gb_wfggM