First Principles Advisory Group

05/30/2018

Interesting white paper from First Principles Advisory Group:

Introduction Encouraging advances have been made in the field of oncology drug development over the past two decades. Exploitation of novel mechanisms

05/09/2018

Fine tuning CAR-T cells to be able to switch targets, control toxicity, and cell-type specific signaling.
https://www.fiercebiotech.com/research/car-t-2-0-a-split-universal-and-programmable-system

05/03/2018

More progress on relapsed imunoncology

Treatment with the TLR9 agonist CMP-001 appeared to potentially reverse resistance to immune checkpoint inhibition in patients with metastatic melanoma. 1

04/26/2018

http://ow.ly/mLiv50hbryZ

A new wave of genetic-based therapies for treating cancer are creating sticker shock, as the drugs and related care for a single patient can run up close to a million dollars.

04/19/2018

New ways of 'thinking' about our immune system:
http://ow.ly/QtYL50h7Fl7
http://ow.ly/nxnz50h7Fl5
http://ow.ly/5kgp50h7FkZ
http://ow.ly/ajvv50h7Fl2

When you hit your head hard, such as during contact sports or in a car accident, it can cause what is known as traumatic brain injury. While in the long te

04/18/2018

A first clinical glimmer of hope that immunotherapy can turn "cold" tumors "hot" and reach its hyped potential.
http://ow.ly/9pGH50h88B8

04/17/2018

Big moves in gene therapy this month:
http://ow.ly/ohm150h7Fkv
http://ow.ly/yzkk50h7Fkw
http://ow.ly/cLRv50h7Fkp
http://ow.ly/1CdT50h7Fks

A gene therapy for the rare disease spinal muscular atrophy could hit the U.S. market next year. If it does, the treatment will likely be sold by Novartis,

04/03/2018

Gut microbiota proving to play a large role in autoimmunity:
http://ow.ly/yIwV50h28sB
http://ow.ly/Umui50h28sO
http://ow.ly/tT3B50h28sL

That means we may be able to treat autoimmune diseases with a vaccine or antibiotic.