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Tisento Therapeutics Developing the first potential treatment for MELAS

Today we're sharing some difficult news. Our Phase 2b PRIZM study did not meet its primary or secondary endpoints, and z...
10/07/2026

Today we're sharing some difficult news. Our Phase 2b PRIZM study did not meet its primary or secondary endpoints, and zagociguat did not show a treatment benefit. Because of this, we have decided to discontinue our clinical program in MELAS and mitochondrial diseases. We know this news is deeply disappointing to the MELAS and broader mitochondrial disease community, and we share that disappointment.

We will be sharing study findings through a community webinar at 7:00 p.m. ET tomorrow (Thursday, October 8). A recording will be made available afterward. Patients, families, and advocates can find webinar details and a community letter here: https://www.tisentotx.com/community-letters/update-october-0726

We are profoundly grateful to the study participants and their families, as well as the investigators, study coordinators, and advocacy organizations that made this study possible. While PRIZM did not produce the benefits for people with MELAS that we had hoped to see, every individual and family who participated helped advance our understanding of the disease and contributed to the broader effort to improve future care and treatment options for people living with MELAS.

Mitoaction
United Mitochondrial Disease Foundation
International Mito Patients
Mito Foundation
Mitocon - Insieme per lo Studio e la Cura delle Malattie Mitocondriali ODV
The Lily Foundation
MitoCanada

Today is the last day of – but the impact and momentum keep growing! No one should face these diseases feeling alone o...
09/20/2026

Today is the last day of – but the impact and momentum keep growing! No one should face these diseases feeling alone or unseen, and through the collective strength of this global community, more and more people are finding connection, support, and hope.

We’re thrilled to see so many buildings lit up green for tonight! This vibrant global display brings people together t...
09/19/2026

We’re thrilled to see so many buildings lit up green for tonight! This vibrant global display brings people together to raise awareness, spark important conversations, and show support for the mito community.

Progress for depends on global collaboration. We’re dedicated to listening to and partnering with patients, families, ...
09/18/2026

Progress for depends on global collaboration. We’re dedicated to listening to and partnering with patients, families, clinicians, advocates, and patient organizations – recognizing the vital role played by each in advancing understanding and improving outcomes for people affected by mitochondrial disease. No single country, organization, or individual can put mito on the map alone. But together, we can.

Putting mito on the map starts with people – speaking up, sharing information, and elevating the voices of those affecte...
09/17/2026

Putting mito on the map starts with people – speaking up, sharing information, and elevating the voices of those affected by these diseases. Visibility matters because many people affected by mito feel isolated or misunderstood. But when communities raise awareness, things change.

We’re proud to support the patient organizations across the globe who are working tirelessly to ensure that mito is recognized in every country, every healthcare system, and in every conversation about rare disease. Together, we can put mito on the map!

Many people with spend years searching for answers before receiving a diagnosis, often seeing multiple specialists alo...
09/16/2026

Many people with spend years searching for answers before receiving a diagnosis, often seeing multiple specialists along the way. Greater awareness among healthcare professionals, policymakers, educators, and the public can help improve understanding of mito, encourage earlier diagnosis, strengthen support systems, and increase investment in innovation.

Mitochondrial disease can affect any organ, at any age, with a wide range of symptoms, making it one of the most challenging conditions to recognize. But better awareness creates opportunities for meaningful and lasting change.

Mitochondrial disease affects people of all ages, backgrounds, and communities across the globe. There are hundreds of d...
09/15/2026

Mitochondrial disease affects people of all ages, backgrounds, and communities across the globe. There are hundreds of different types of mitochondrial diseases, many of which are individually rare or ultra-rare. Collectively, an estimated 1 in 5,000 people live with a mitochondrial disease, equivalent to approximately 1.5 million people worldwide.

We’re developing a potential treatment for the rare mitochondrial disease (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes). MELAS is a heterogeneous disease, with fatigue- and cognitive-related symptoms reported most frequently. Learn more: https://www.tisentotx.com/mito-diseases

It’s ! We’re energized by the opportunity to join International Mito Patients (IMP) in raising awareness of these chall...
09/15/2026

It’s ! We’re energized by the opportunity to join International Mito Patients (IMP) in raising awareness of these challenging diseases.

This year, the official theme is . It focuses on making mitochondrial disease more visible globally by amplifying patient voices, strengthening awareness, supporting advocacy, and connecting people across borders. “Putting Mito on the Map” is about ensuring that no person living with mito feels unseen, unheard, or isolated, no matter where they live.

This summer, we’re revisiting the United Mitochondrial Disease Foundation “Our MELAS Voices” video series, which we were...
09/09/2026

This summer, we’re revisiting the United Mitochondrial Disease Foundation “Our MELAS Voices” video series, which we were honored to support.

Meet the Strosnider family. Bronya and Neil share the story of their daughter Brooke, an adult living with . Before MELAS changed her life, Brooke earned a Master’s degree in art therapy, ran marathons, and opened a corporate gym. Everything changed when she had a stroke-like episode. She was hospitalized but did not receive a correct diagnosis right away. As the family continued to seek answers, her symptoms worsened, affecting her language, movement, cognition, fatigue, independence, work, and social life dramatically.

See the Strosnider family’s story here: https://www.umdf.org/melas/

Brooke’s story inspires us as we continue to work toward developing a treatment for MELAS.

This summer, we’re revisiting the United Mitochondrial Disease Foundation “Our MELAS Voices” video series, which we were...
08/31/2026

This summer, we’re revisiting the United Mitochondrial Disease Foundation “Our MELAS Voices” video series, which we were honored to support.

Meet Patricia! In this video, Patricia shares how has affected her social life and ability to work, and caused challenging symptoms such as seizures, aphasia, hearing loss, atrial fibrillation, and more.

See Patricia’s story here: https://www.umdf.org/melas/

Patricia’s story inspires us as we continue to work toward developing a treatment for MELAS.

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