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Tisento Therapeutics

Developing the first potential treatment for MELAS

08/31/2026

This summer, we’re revisiting the United Mitochondrial Disease Foundation “Our MELAS Voices” video series, which we were honored to support.

Meet Patricia! In this video, Patricia shares how has affected her social life and ability to work, and caused challenging symptoms such as seizures, aphasia, hearing loss, atrial fibrillation, and more.

See Patricia’s story here: https://www.umdf.org/melas/

Patricia’s story inspires us as we continue to work toward developing a treatment for MELAS.

08/25/2026

This summer, we’re revisiting the United Mitochondrial Disease Foundation “Our MELAS Voices” video series, which we were honored to support.

Meet the Hauner family. Chelsea lives with , and her mom Alysia supports and advocates for her every step of the way.

Alysia describes how this rare affects Chelsea’s brain. “Mitochondria are the powerhouses of the cell, give your body energy. Sometimes you get mitochondria that don’t want to cooperate. Where Chelsea’s do not cooperate is her brain; they cause her to have seizures and stroke-like episodes and lengthy hospital stays.”

See the Hauner family’s story here: https://www.umdf.org/melas/

Chelsea’s story inspires our work toward developing a treatment for MELAS.

08/19/2026

This summer, we’re revisiting the United Mitochondrial Disease Foundation “Our MELAS Voices” video series, which we were honored to support.

Meet the Sterchi family. Steve and Jamie share how they support their son Brady, whose journey began suddenly just before his second birthday, when a mild fever escalated into uncontrollable seizures. He was taken by helicopter to the children’s hospital, where he was put into a medically induced coma for three weeks.

“They were fearing for his life. They did not know if we would take him home. They did not know if we would be leaving the hospital with him,” recounts Brady’s mom Jamie.

See the Sterchi family’s story here: https://www.umdf.org/melas/

Brady’s story inspires our work toward developing a treatment for MELAS.

08/13/2026

Last year, we partnered with Mitocon - Insieme per lo Studio e la Cura delle Malattie Mitocondriali ODV to share stories of those impacted by . It was a privilege to get to know Roberto and Anna, and we’re grateful they shared their journey.

Roberto and Anna have been married for more than 30 years after meeting at university. After a long diagnostic journey, Roberto was diagnosed with MELAS. He has experienced stroke-like episodes, reduced muscle mass, difficulties with balance, hearing loss, and cognitive and language issues. As Roberto’s condition has progressed, many things in their lives have changed, and Anna has taken on more caregiving responsibilities. Through it all, they continue to support one another and live life as fully as possible.

Stories like Roberto and Anna’s inspire our work toward developing a treatment for MELAS.

Watch it here: https://youtu.be/mwkczr_QDxg The video is in Italian with optional English closed captions.

08/04/2026

Last year, we partnered with Mitocon - Insieme per lo Studio e la Cura delle Malattie Mitocondriali ODV to share stories of those impacted by . We were honored to get to know Morena and learn more about her journey.

Morena is a mom of three adult children and a retired nurse whose journey to a MELAS diagnosis took years. She experiences difficulty walking, neurological challenges, seizures, and a reduced quality of life. With support from Mitocon and others living with MELAS, Morena has found belonging and encouragement while navigating the daily challenges of her condition.

Stories like Morena’s inspire our work toward developing a treatment for MELAS.

Watch it here: https://youtu.be/bFciPejLNPg The video is in Italian with optional English closed captions.

07/22/2026

What’s on your summer reading list? We’re adding “The Donkey and the Cart: How a Father’s Grief Became a Medical Movement” – a memoir by Charles A. Mohan Jr., the founder of the United Mitochondrial Disease Foundation (UMDF), that’s coming soon. We’re looking forward to learning more about the UMDF’s grassroots beginnings in Mr. Mohan’s basement – from producing educational newsletters to organizing walkathons – honoring the legacy of his daughter Gina, whose life was taken by . https://umdf.org/the-donkey-and-the-cart/

06/22/2026

That’s a wrap on ! We’re grateful to the United Mitochondrial Disease Foundation for bringing everyone together, and we’re already looking forward to next year!

06/20/2026

Don’t miss the Masterclass at the United Mitochondrial Disease Foundation conference! Some of the world’s leading clinicians and researchers will spend a full morning educating about this . The morning will conclude with an interview with an individual living with MELAS to better understand the lived experiences associated with this disease.

06/17/2026

At last year’s United Mitochondrial Disease Foundation conference, we sponsored the mitoARCH (Mitochondrial All-Comers Research on Cognitive Health) study. Cognitive health is an under-researched aspect of , and the study was designed to unearth new insights to shape clinical trials that better measure the symptoms that are most common and important to patients.

Today we’re coming full circle by sharing the results of the mitoARCH in a poster at this year’s , presented by Dr. Amel Karaa, director of the mitochondrial disease program at Massachusetts General Hospital. Check out the poster tonight or tomorrow!

06/15/2026

The Mitochondrial Disease Foundation Conference is just around the corner! We’re looking forward to sharing more about our clinical program, including the fully enrolled Phase 2b PRIZM study in and the results of the mitoARCH study we sponsored at last year’s conference focused on the impact of mitochondrial disease on cognitive health. Stop by our booth to learn more!

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