MIT iGEM

MIT iGEM Hi! We are MIT's 2012 iGEM team. iGEM (The International Genetically Engineered Machines) Competition is an undergraduate Synthetic Biology competition.

Imagine being able to diagnose and destroy diseased cells using RNA. This can be accomplished by using RNA strand displacement cascades that recognize certain mammalian cell-specific biomarkers, such as characteristic mRNA strands or metabolites, use these as abstract inputs to digital logic cates, and then yield a wide array of desired outputs. We propose a new method of implementing the paradigm

s of sensing, processing, and actuation inside mammalian cells by applying the mechanism of DNA strand displacement from the field of nucleic acid computation to RNA. Traditional synthetic biology approaches seem to have hit a barrier in terms of the number of regulatory components that can be used predictably and reliably, limiting the complexity of cellular circuits. On the other hand, the strand displacement method of molecular computing within mammalian cells is highly modular, scalable, and orthogonal. We have demonstrated that RNA can be used as a processing medium, and have proposed novel in vivo NOT gates, which along with AND and OR gates can directly be produced inside mammalian cells. Currently, we are developing modeling platforms to explore kinetics of strand displacement reactions in vivo, as well as designing actuation systems that allow the RNA logic to interface with a variety of protein outputs. Our integrated approach can fundamentally impact the fields of biological engineering, biomedical engineering, and medical diagnostics. Thank you to our sponsors: MIT EECS, MIT BE, iGEM, Alnylam Pharmaceuticals, Genious, Genewiz, New England Biolabs, Addgene, Genscript, MIT ChemE, Pfizer, EBICS, MIT EHS, Monsanto, Flagship Ventures, Third Rock Ventures and Integrated DNA Technologies.

11/04/2012

Wow what an exciting day! We loved sharing our work with everyone and hearing about so many amazing projects!

Poster session at 5 in Stata! :)

we finished our wiki! http://2012.igem.org/Team:MIT
10/27/2012

we finished our wiki! http://2012.igem.org/Team:MIT

Imagine being able to diagnose and destroy diseased cells using RNA. This can be accomplished by using RNA strand displacement cascades that recognize certain mammalian cell-specific biomarkers, such as characteristic mRNA strands or metabolites, use these as abstract inputs to digital logic gates, ...

10/26/2012

Wiki freeze tomorrow and only a week until the World Jamboree!!

With iGEM 2012 drawing to a close, we are so so thankful for our sponsors who have made all of our work possible. We couldn't have done this without you. A big thank you to - MIT EECS, MIT BE, iGEM, Alnylam Pharmaceuticals, Genious, Genewiz, New England Biolabs, Addgene, Genscript, MIT ChemE, Pfizer, EBICS, MIT EHS, Monsanto, Flagship Ventures, Third Rock Ventures, Karl Handelsman, and Integrated DNA Technologies

10/15/2012

We are proud to announce that we have moved on to compete at the World Championship Jamboree at MIT in November! We have also won a gold medal for our work so far! Thanks to everyone who made this possible and thanks to iGEM for providing an amazing weekend in Pittsburgh!!

10/12/2012

We are on our way to Pittsburgh for the Americas East Regional iGEM Jamboree!! We are so excited to present our work and see what everyone has accomplished this year!

09/28/2012

Shout out to all of our amazing sponsors who made all of our research possible! :)

MIT EECS, MIT BE, iGEM, Alnylam Pharmaceuticals, Geneious, Genewiz, New England Biolabs, Addgene, GenScript, EBICS, MIT EHS, Monsanto, Flagship Ventures and Integrated DNA Technologies

09/21/2012

Collecting data and editing the wiki!
Only 3 weeks until the Americas East regional jamboree in Pittsburgh!

09/07/2012

excited to meet up, help out and get feedback on our project with the BU, Brown-Stanford and Wellesley iGEM teams on Sept. 15th for the New England iGEM (NEGEM) meeting!!!

07/26/2012

Making progress! Watch out soon for website updates :)

We can't wait to collaborate with the BU and Wellesley iGEM teams tomorrow and test their software!

07/16/2012

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