10/14/2026
As the industry considers more large-volume SC therapies, challenging long-held assumptions could open the door to new possibilities in formulation and device strategy.
A recent ONdrugDelivery article from Enable Injections brings together findings from multiple industry surveys and publications, along with regulatory approvals, to take a closer look at the commonly cited 2-3 mL limit.
The conversation around SC delivery is evolving. Take a closer look at the evidence behind it:
Dr Haydon DuMond, Dr Mehul Desai, along with Dr Shirish Ingawale, examine survey evidence and regulatory precedent showing that the widely cited 2–3 mL limit on subcutaneous delivery reflects device history and information habits rather than tissue biology, and consider the consequences for formul...