08/26/2026
Research Spotlight | Viruses (2026)
What could limit MK-2048 for HIV prevention?
Researchers investigating MK-2048 found that the HIV integrase inhibitor is a substrate of two important efflux transporters, P-gp and BCRP. Because both are highly expressed in the female reproductive tract, their activity may influence MK-2048 concentrations in target tissue.
The experimental workflow also incorporated equipment from IBI Scientific: researchers used an IBI Scientific vacuum manifold to rapidly filter and wash samples during the membrane vesicle uptake assay.
The study offers insight into how drug transport across biological barriers may influence potential HIV prevention strategies.
🔬 Read the full study:
https://doi.org/10.3390/v18050561