BioSkryb Genomics, Inc.

09/27/2024

We are thrilled to participate in Stockholm Single Cell Genomics 2024, hosted by SciLifeLab National Genomics Infrastructure - NGI. There will be two presentations featuring BioSkryb Genomics products.

First, hear Alexander Steemers, a PhD Candidate, in Ruben van Boxtel's laboratory present on “Tracing the Origin of Lymphomas: Insights from Single-Cell Whole Genome Sequencing".

Next our very own Luca Mazzitelli will also be presenting "High-Resolution Single-Cell Multiomic Analysis with BioSkryb Genomics’ Innovative Solutions".

Agenda and Registration: https://ngisweden.scilifelab.se/events/stockholm-single-cell-genomics-2024-symposium/

09/27/2024

Next month join us virtually or in-person for the Singapore Single-cell Network taking place on Tuesday, October 8th at 5:30-7:30pm (SGT)!

Tune in to hear from:

Shyam Prabhakar, PhD (Associate Director and Senior Group Leader) at the Genome Institute of Singapore

Joseph Gleeson, PhD (Rady Professor of Neuroscience, UCSD) who will be presenting "Treating the Untreatable: Genetic Investigation of Pediatric Brain Disease"

Magda Grabowska, PhD (Senior Director of Scientific Engagement, BioSkryb Genomics) who will be presenting "Leveraging Single Cell DNA-informed Multiomics in Cancer Research"

Vikrant Kumar, PhD (Director of Scientific Affairs and Bioinformatics, Mirxes) who will be presenting "Integrated Analysis of Single-cell Genomics and Transcriptomics Dataset from the Same Cell"

Register to join the event virtually ⤵
https://us06web.zoom.us/webinar/register/WN_uqHMB_OFTBacL73tuTTd8Q #/registration

09/26/2024

BioSkryb Genomics x Human Cell Atlas

Today, we are thrilled to announce a new partnership with the Human Cell Atlas that will help increase access to our industry-leading single-cell multiomics technology!

This partnership will allow HCA collaborating members to more readily access BioSkryb's technology and gain support in applying the next-generation single-cell technology to their research.“

By partnering with the HCA, we can increase access to our powerful technology and develop new connections with other collaborating consortium members working toward major advances in the way diseases are diagnosed and treated.” - Suresh Pisharody, CEO of BioSkryb

Read more about the BioSkryb Genomics x Human Cell Atlas partnership ⤵
bioskryb.com/news/bioskryb-partners-with-human-cell-atlas/

09/25/2024

Publication highlight: Huber et al. Cancer Cell. 2024

This study from Ruben van Boxtel’s group, in collaboration with Hans Clevers, demonstrated improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer.

In this study, Huber et al., leveraged ResolveDNA® for single-cell whole genome sequencing of intestinal organoids exposed to different strains of E. coli.

Read the full publication here:
https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00053-9

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09/23/2024

Join us this weekend at the Human Cell Atlas General Meeting 2024 held in Milan, Italy on Sept. 29th – Oct. 1st! Have you encountered limitations when using traditional single-cell amplification methods?

Our ResolveDNA® & ResolveOME™ kits are powered by Primary Template-directed Amplification (PTA) proving you the most comprehensive single-cell genomic and multiomic analysis.

ResolveDNA covers >95% of the genome, providing you high fidelity, even, and complete coverage from each individual cell.

ResolveOME builds on this by combining our powerful amplification method with whole transcriptome analyses.

Want to learn more?
Schedule a meeting with us at ⤵
go.bioskryb.com/l/1010901/2024-09-23/2r9vx

09/19/2024

Predictive algorithms can miss >85% of CRISPR off-target indels.

There is a better way...

Over 85% of CRISPR off-target indels detected using ResolveDNA® were missed by an in silico prediction method.

Read our poster originally presented at the 2023 Annual Meeting to learn how single-cell WGS enabled by ResolveDNA allows comprehensive genomic characterization of gene-edited cells.

In this poster, Isai Salas-González, PhD and Victor Weigman, PhD describe cell-to-cell variability of CRISPR on-target and off-target edits. They also show how a single ResolveDNA WGS assay can identify an array of CRISPR-induced genomic changes, including:

- Off-target indels
- Copy number variants
- Translocations

View poster here: go.bioskryb.com/l/1010901/2024-09-19/2r5jq

09/17/2024

We’re here at the Cambridge Lymphoma Biology International Symposium!

Are you ready to take your single-cell analysis to a new level?

Stop by our booth to discover how our primary-template directed amplification (PTA) technology could enable your future research.

Event Details:
🗓 Date: 17th September – 18th September 2024
📍 Location: Magdalene College, Cambridge

BioSkryb’s ResolveDNA®, powered by PTA, advances next-generation sequencing, enabling whole genome amplification at the single-cell level. Additionally, ResolveOME™ allows for simultaneous amplification of the genome and transcriptome within the same cell, providing unprecedented insights into genomic structure and gene expression.

These new products have been designed to provide an end-to-end kitted solution with a reduced workflow under eight hours, while maintaining 97% genomic coverage.

Not attending?
Visit bioskryb.com to learn more about us!

09/16/2024

When it comes to CRISPR gene editing, the term "off-target edits" often enters the conversation. But what are they, and why do they matter?

Off-target edits refer to unintended DNA changes that occur at genomic locations other than the CRISPR target location. These edits can happen when the guide RNA directs Cas9 to a sequence with less-than-perfect homology, or even without any apparent sequence match. Factors like impurities in guide RNA preparations or previously unrecognized sequence differences between the genomes of the edited cells and the reference genome used during guide RNA design can also contribute to these off-target modifications.

Understanding off-target edits is critical because they can negatively impact interpretation of experimental results when using these cells in research and in the context of gene-edited medicines, off-target edits can reduce efficacy or pose serious safety risks.

Want to learn more?
To talk to a CGT expert today: bioskryb.com/cgt-contact/

09/12/2024

Next week, join us at the Cambridge Lymphoma Biology International Symposium on September 17th – 18th! The event will be held at Magdalene College in Cambridge, England.

Connect with us and discover how our 🧬 ResolveDNA® & ResolveOME™ kits 🧬 powered by PTA, can advance your research. Unlock multiple tiers of dynamic molecular insights—all from a single cell.

Make sure to swing by our booth and say hi!

09/10/2024

Part two of our APAC Roadshow in Daejeon and Seoul was a blast! Attendees were introduced to BioSkryb’s ResolveDNA® and ResolveOME™ products, powered by our novel Primary Template-directed Amplification (PTA) technology.

The single-cell revolution is here, but the adage remains true: the quality of your input dictates the quality of your output.

How can you maximize the quality of your samples while maintaining an efficient and scalable workflow?

Our novel PTA technology allows sequencing over 97% of a single cell’s genome with exceptional uniformity, accuracy, and precision.

Missed us along our APAC Roadshow?

Take a look at our distributor list at bioskryb.com/distributors or get in touch with one of our single-cell experts at bioskryb.com/contact/

A big thank you to MDxK | 엠디엑스케이 for organizing and Vizgen for co-hosting the events!

09/05/2024

Last Chance to register for the second leg of our APAC Roadshow in South Korea 🇰🇷 next week! Join us in Daejeon and Seoul on September 9th and 10th. Learn more ⤵

Explore the latest advancements in:

with BioSkryb Genomics
with Vizgen Don't miss this opportunity to connect with experts and discover how our technologies can transform your research!

📅 Dates & Locations:
Sep 9: Daejeon (last few spots remain!)
Sep 10: Seoul*
*In order to accommodate more people, the location in Seoul has been changed to Lecture Hall-2 (Room 6102) on the 6th floor of the 1st Medical Building of Korea University! We have also planned an exclusive event for the attendees of this roadshow, so please refer to the registration page for details.

Connect with experts and discover how our technologies can transform your research!

Register here: go.mdxk.co.kr/2024-09-High-Resolution-Biology-Roadshow-Korea

🎙️Speakers:
- Hoyeon Jeong, Ph.D. Samsung Medical Center
- George Emanuel, Ph.D. Vizgen
- Daeseung Lee, Ph.D. Portrai
- Eunice Wong, Ph.D. BioSkryb Genomics

Organized by: MDxK | 엠디엑스케이

09/03/2024

We had a fantastic time in Japan 🇯🇵 for the first leg of our APAC Roadshow. Thank you to all those who came out in Tokyo and Osaka!

South Korea 🇰🇷 we'll see you next week! Join us for the second leg of our APAC Roadshow in Daejeon and Seoul on September 9th and 10th.

Explore the latest advancements in:

with BioSkryb Genomics
with Vizgen

📅 Dates & Locations:

Sep 9: Daejeon, South Korea
Sep 10: Seoul, South Korea

Register here: https://go.mdxk.co.kr/2024-09-High-Resolution-Biology-Roadshow-Korea

Organized by: MDxK | 엠디엑스케이