05/11/2026
In this week’s spotlight, we’d like to recognize the groundbreaking work on the host immune dynamics of lethal tick-borne viruses and the innovative use of transient immune suppression to model these diseases in vivo.
Read the Article here: https://hubs.la/Q04g72zW0
This research article, "Dynamic Changes in Host Immune Response During Crimean–Congo Hemorrhagic Fever and Severe Fever with Thrombocytopenia Syndrome in Mice," addresses the challenge of studying high-consequence pathogens like CCHFV and SFTSV, which often require immunocompromised models to establish infection. Researchers at USAMRIID utilized a transient interferon suppression (IS) model by administering Leinco’s In Vivo Platinum™ Anti-Mouse IFNAR-1 (Clone MAR1-5A3). This approach allowed for a window of viral replication and disease progression in otherwise resistant adult mice. By performing targeted transcriptomic analysis, the team identified distinct immune signatures—finding that CCHFV drives a progressively evolving interferon-driven response while SFTSV triggers rapid, sustained immune activation. These insights are critical for identifying early biomarkers and developing targeted countermeasures against these emerging global threats.
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Anti-Mouse IFNAR-1 [Clone MAR1-5A3]: https://hubs.la/Q04g7nd60
Crimean–Congo hemorrhagic fever virus (CCHFV) and severe fever with thrombocytopenia syndrome virus (SFTSV) are tick-borne pathogens that cause severe illness and high mortality. Early diagnosis is critical, particularly in resource-limited settings, to enable timely intervention. Host gene expres...
