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Olaris, Inc, 175 Crossing Boulevard, Suite 410, Framingham, MA (2026)

09/04/2026

𝗙𝗿𝗶𝗱𝗮𝘆 𝗙𝘂𝗻 𝗙𝗮𝗰𝘁

The human metabolome contains over 200,000 types of metabolites. It's the full set of small molecules — called metabolites — in our body, measurable in a biological fluid like blood or urine. Metabolites are produced by our own cells and our gut microbiome, and are also taken in through the food we eat. Metabolome composition varies between people. Diet and gut microbiome have a stronger role than genetics in shaping metabolome variation between individuals.

Metabolomics is the study of metabolomes. Our metabolome is a record of what's happening in our body. Olaris uses metabolomics, machine learning, and biology to build and power diagnostics that reveal what is happening in disease. Find out more: myolaris.com

Sources: Chen, L., et al. (2022) 10.1038/s41591-022-02014-8; The Human Metabolome Database (https://www.hmdb.ca/)

09/03/2026

𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗼𝗺𝗶𝗰𝘀, 𝗺𝗮𝗰𝗵𝗶𝗻𝗲 𝗹𝗲𝗮𝗿𝗻𝗶𝗻𝗴, 𝗮𝗻𝗱 𝗯𝗶𝗼𝗹𝗼𝗴𝘆: 𝗪𝗵𝗮𝘁 𝗱𝗼𝗲𝘀 𝗶𝘁 𝗺𝗲𝗮𝗻 𝘁𝗼 𝗼𝘄𝗻 𝘁𝗵𝗲 𝗳𝘂𝗹𝗹 𝗽𝗿𝗼𝗰𝗲𝘀𝘀?

Metabolomics is the data. Machine learning finds the patterns. Biology decides what they mean. The more common approach in metabolomics is to take on one part of the process, data acquisition, statistical analysis, or biological interpretation, and hand the rest to another team or vendor. When each group of specialists work separately in their own scientific language, things can be missed or misinterpreted along the way.

At Olaris, those specialists are part of one team. Instead of passing a finished piece down the line, they discuss results together, in language everyone on the team can follow.

That same integrated process holds no matter what form the work takes. Whether Olaris is developing a new diagnostic, partnering with a pharmaceutical, biotech, or academic research team, or processing one of our laboratory-developed tests, the scientific standard stays the same.

The science underlying metabolomics is established. What Olaris has built is the ability to apply it at a scale and level of reproducibility the field has not consistently achieved — which is why the results hold up.

Find out more: myolaris.com

09/01/2026

𝗛𝗼𝘄 𝗧𝗵𝗶𝗻𝗴𝘀 𝗪𝗼𝗿𝗸: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗼𝗺𝗶𝗰𝘀, 𝗠𝗮𝗰𝗵𝗶𝗻𝗲 𝗟𝗲𝗮𝗿𝗻𝗶𝗻𝗴, 𝗮𝗻𝗱 𝗕𝗶𝗼𝗹𝗼𝗴𝘆

Olaris is a precision diagnostics company that builds and powers diagnostics using metabolomics, machine learning, and biology. Here's how those three pieces actually work together.

Metabolomics is the study of small molecules called metabolites that your body produces as it functions. The mix and amount of metabolites in a biosample, like blood or urine, changes in real time as disease develops. Using tools like NMR and mass spectrometry, scientists at Olaris can detect up to thousands of these metabolite signals in a single sample. Finding the patterns that actually matter among all that data is a bit like searching for a needle in a haystack.

That's where machine learning comes in. It's built to spot patterns across many metabolites at once, that a person might miss, or take too long to find, and narrow all that data down to the leads worth a closer look. Machine learning doesn't find the answers on its own. It finds leads.

From there, deep biological expertise guides what happens next. We know when to be cautious, when a lead is worth following, and how to turn it into something clinically useful.

Metabolomics, machine learning, and biology work together as one process, that Olaris owns from start to finish.

Find out more: myolaris.com

08/28/2026

Olaris is a precision diagnostics company built on the integration of metabolomics, machine learning, and biology. Olaris uncovers what metabolites can tell us about what's happening in the body to help inform timely clinical decisions, filling the gap when other tools may indicate problems too late or require an invasive procedure to get closer to the truth. Post-transplant care was where that gap first showed up most clearly – and where the science, the clinical need, and the right physician relationships all lined up first.

After kidney transplant, it is important for recipients to receive the right amount of immunosuppressant medication, consistently, to prevent the body from rejecting the transplanted kidney. myOLARIS® -MMF Drug Signature is a commercially available urine-based LDT developed to support monitoring of kidney transplant recipient adherence to immunosuppressant medication, so the care team can help if barriers to adherence come up. myOLARIS® -KTdx was the first clinical proof of what the Olaris platform can do. This urine-based test for surveillance of kidney graft injury supports clinical reasoning on whether immunosuppression levels are right for the individual and informs the decision on whether or when to perform a biopsy.

Olaris is also developing a urine-based assay for surveillance of kidney graft injury in pediatric transplant recipients (myOLARIS® -pKTdx) and a plasma-based assay to identify liver transplant recipients at increased risk for cardiovascular diseases and complications (myOLARIS® -CVD LTdx).

The platform is not limited to one disease, one organ system, or one clinical question. The same approach applies anywhere better information could change what a clinician decides to do next. Every new tool comes from the same platform and is held to the same standard. Find out more: myolaris.com

08/27/2026

𝗙𝗼𝗿 𝗮𝗻𝘆𝗼𝗻𝗲 𝘄𝗵𝗼 𝗵𝗮𝘀 𝗯𝗲𝗲𝗻 𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗮 𝗸𝗶𝗱𝗻𝗲𝘆 𝘁𝗿𝗮𝗻𝘀𝗽𝗹𝗮𝗻𝘁 𝗼𝗿 𝗰𝗮𝗿𝗲𝘀 𝗳𝗼𝗿 𝘀𝗼𝗺𝗲𝗼𝗻𝗲 𝘄𝗵𝗼 𝗵𝗮𝘀, 𝘆𝗼𝘂 𝗸𝗻𝗼𝘄 𝗵𝗼𝘄 𝗺𝘂𝗰𝗵 𝗺𝗼𝗻𝗶𝘁𝗼𝗿𝗶𝗻𝗴 𝗰𝗼𝗺𝗲𝘀 𝗮𝗳𝘁𝗲𝗿𝘄𝗮𝗿𝗱𝘀. 𝗧𝗲𝘀𝘁 𝗿𝗲𝘀𝘂𝗹𝘁𝘀 𝗰𝗼𝗺𝗲 𝗯𝗮𝗰𝗸. 𝗡𝘂𝗺𝗯𝗲𝗿𝘀 𝘀𝗵𝗶𝗳𝘁. 𝗬𝗼𝘂𝗿 𝗽𝗵𝘆𝘀𝗶𝗰𝗶𝗮𝗻 𝗶𝘀 𝘄𝗮𝘁𝗰𝗵𝗶𝗻𝗴 𝗰𝗹𝗼𝘀𝗲𝗹𝘆, 𝗮𝗻𝗱 𝘀𝗼 𝗮𝗿𝗲 𝘆𝗼𝘂. 𝗬𝗲𝘁 𝘁𝗵𝗲 𝘁𝗼𝗼𝗹𝘀 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲 𝗼𝗳𝘁𝗲𝗻 𝗹𝗲𝗮𝘃𝗲 𝘂𝗻𝗰𝗲𝗿𝘁𝗮𝗶𝗻𝘁𝘆 𝗳𝗼𝗿 𝘆𝗼𝘂 𝗯𝗼𝘁𝗵.

myOLARIS® -KTdx is a urine-based test that can give clinicians a clearer picture of how the kidney is doing, without a biopsy. A clinician orders it, interprets the results, and uses it to inform next steps.

If your care team orders myOLARIS® -KTdx as part of your post-transplant monitoring, here's what the report actually looks like.

Instead of a single pass/fail result, myOLARIS® -KTdx returns a similarity-based score that places your sample into one of four categories: stable, trending toward rejection, trending toward infection risk, or borderline.

It's not a diagnosis, and it doesn't replace a biopsy. It's one more piece of information your clinician can use — alongside your labs, your history, and how you're feeling — to decide what happens next.

You are not just managing a transplant. You are living your life. Whether you're thinking about raising myOLARIS® -KTdx with your care team or you’ve had the test and want help discussing results with your doctor, we're here to help you prepare for those conversations.
Reach out: https://www.myolaris.com/transplant-recipients-and-caregivers

08/25/2026

𝗬𝗼𝘂𝗿 𝗯𝗼𝗱𝘆 𝗺𝗮𝗸𝗲𝘀 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘁𝗲𝘀 𝗮𝗹𝗹 𝗱𝗮𝘆, 𝗲𝘃𝗲𝗿𝘆 𝗱𝗮𝘆 — 𝗯𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝗱𝗼𝘄𝗻 𝗳𝗼𝗼𝗱 𝗶𝗻𝘁𝗼 𝗲𝗻𝗲𝗿𝗴𝘆 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗯𝘂𝗶𝗹𝗱𝗶𝗻𝗴 𝗯𝗹𝗼𝗰𝗸𝘀 𝗶𝘁 𝘂𝘀𝗲𝘀 𝘁𝗼 𝗿𝗲𝗽𝗮𝗶𝗿 𝗶𝘁𝘀𝗲𝗹𝗳. 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝘁𝗵𝗮𝘁 𝗽𝗿𝗼𝗰𝗲𝘀𝘀. 𝗜𝘁 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝘄𝗵𝗶𝗰𝗵 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘁𝗲𝘀 𝘀𝗵𝗼𝘄 𝘂𝗽, 𝗮𝗻𝗱 𝗵𝗼𝘄 𝗺𝘂𝗰𝗵 𝗼𝗳 𝗲𝗮𝗰𝗵 𝗼𝗻𝗲 𝗶𝘀 𝘁𝗵𝗲𝗿𝗲.

Olaris is a precision diagnostics company that integrates metabolomics, machine learning, and biology to build and power diagnostics. Mass spectrometry is one of the tools Olaris uses to measure those changes.

It works by giving molecules a charge, then sorting them by mass as electric fields push and pull them through the instrument. Molecules of different masses respond differently to the same field, and that's what lets the instrument tell one metabolite from another.

NMR and mass spectrometry are two of the measurement technologies Olaris relies on. Together, they let the platform measure metabolites broadly and reproducibly, across sample types. Find out more: myolaris.com

08/21/2026

𝗠𝗼𝘀𝘁 𝗽𝗲𝗼𝗽𝗹𝗲 𝘁𝗵𝗶𝗻𝗸 𝗼𝗳 𝘂𝗿𝗶𝗻𝗲 𝗮𝘀 𝘀𝗼𝗺𝗲𝘁𝗵𝗶𝗻𝗴 𝘆𝗼𝘂𝗿 𝗸𝗶𝗱𝗻𝗲𝘆𝘀 𝗮𝗻𝗱 𝗯𝗹𝗮𝗱𝗱𝗲𝗿 𝗵𝗮𝗻𝗱𝗹𝗲. 𝗜𝘁'𝘀 𝗮𝗰𝘁𝘂𝗮𝗹𝗹𝘆 𝗮 𝘄𝗵𝗼𝗹𝗲-𝗯𝗼𝗱𝘆 𝗿𝗲𝗰𝗼𝗿𝗱.

As blood circulates, it picks up metabolic byproducts from tissue throughout the body — muscle, liver, gut, wherever cells are active. The kidneys filter that blood, reabsorbing what the body needs and letting the rest pass through. What's left in urine is a chemical trace of metabolism happening everywhere, not just in the kidneys themselves.

That's part of why it's such a useful sample in medicine: it's non-invasive, and it's already carrying a body-wide signal of what's happening inside you.

Olaris develops urine-based diagnostics by reading these metabolic byproducts and other small molecules produced in the body as it functions and uncovering the metabolic signals that tell us about what’s happening in disease. Find out more: myolaris.com

08/20/2026

Metabolites are a record of what's happening in the body, shaped by everything acting on it at once, and something we can read from a simple urine sample.

After a kidney transplant, the care team needs to know two things: is the kidney stable, and is the immunosuppression dose right? Too little immunosuppression risks rejection. Too much raises the risk of infection and other complications. Getting that balance right matters, and it isn't always easy to see from routine bloodwork alone.

Biopsy remains the most definitive way to check for graft injury, but it's invasive, not always possible, and comes with its own risks. That's the gap our first laboratory-developed test, myOLARIS® -KTdx, was built to help close — a non-invasive urine test that gives the care team more information to work with, without replacing their judgment.

Here's how it works: the clinician orders the test, the transplant recipient provides a urine sample, and it's sent to our CLIA-certified laboratory. Results typically come back in 3 to 5 business days.

If you or someone you love has had a kidney transplant and you want to understand how this fits into post-transplant care, talk to your transplant team — or visit the link below to learn more.
https://www.myolaris.com/transplant-recipients-and-caregivers

08/18/2026

𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘁𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗠𝗼𝗻𝘁𝗵 — 𝗟𝗮𝗰𝘁𝗮𝘁𝗲, 𝗣𝗮𝗿𝘁 𝗧𝘄𝗼: 𝗟𝗮𝗰𝘁𝗮𝘁𝗲 𝗶𝗻 𝗠𝗲𝗱𝗶𝗰𝗶𝗻𝗲

Last time, we covered how lactate helps power your muscles through a hard workout. But lactate also shows up in the emergency room and ICU, where it can tell your care team a lot about what's happening in your body.

When oxygen has trouble reaching tissues — because of a serious infection, internal bleeding, or certain kinds of heart failure — lactate levels rise. That's one reason it's often among the first labs checked when someone comes in looking unwell.

Lactate can also rise when stress hormones cause the body to produce more of it than usual — even when oxygen isn't the issue — or when kidney or liver failure cause slower clearance from the body,

On its own, lactate levels don’t provide a diagnosis. Clinicians read this metabolite biomarker alongside vital signs, history, and exam findings to understand the full picture.

Lactate is a good example of metabolites being useful in medicine as a readout of body function that provides critical information for treatment decisions. That same idea sits at the center of the Olaris platform, built on the integration of metabolomics, machine learning, and biology to unlock more of what metabolites can tell us about what's happening in the body. Olaris develops metabolite signature-based tests that fill clinical needs, like myOLARIS® -KTdx, designed to support kidney transplant surveillance. This test does not replace clinical reasoning; it helps provide a fuller picture where the consequences of acting on incomplete information could damage the transplanted kidney or harm the transplant recipient.

Visit https://www.myolaris.com/ to find out more.

08/14/2026

𝗙𝗿𝗶𝗱𝗮𝘆 𝗙𝘂𝗻 𝗙𝗮𝗰𝘁: 𝘁𝗵𝗲 𝗺𝗮𝗰𝗵𝗶𝗻𝗲 𝘆𝗼𝘂𝗿 𝗱𝗼𝗰𝘁𝗼𝗿 𝘂𝘀𝗲𝘀 𝗳𝗼𝗿 𝗮𝗻 𝗠𝗥𝗜 𝘀𝗰𝗮𝗻 𝗮𝗻𝗱 𝘁𝗵𝗲 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝘄𝗲 𝘂𝘀𝗲 𝘁𝗼 𝗿𝗲𝗮𝗱 𝘆𝗼𝘂𝗿 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘁𝗲𝘀 𝗮𝗿𝗲 𝘄𝗼𝗿𝗸𝗶𝗻𝗴 𝗼𝗳𝗳 𝘁𝗵𝗲 𝘀𝗮𝗺𝗲 𝗰𝗼𝗿𝗲 𝗽𝗵𝘆𝘀𝗶𝗰𝘀.

Both rely on nuclear magnetic resonance (NMR) — atomic nuclei aligning in a magnetic field, then giving off a signal when energy from a radiofrequency pulse excites them. An MRI scan turns that signal into a picture of soft tissue.

We use it differently. Instead of a picture, we use NMR to read the signals given off by metabolites in a biosample, turning them into a molecular fingerprint of what's happening inside your body.

Same physics, two different ways of asking what's happening inside you.

Olaris uses NMR to read metabolic patterns associated with graft injury in kidney transplant, cardiovascular risk in liver transplant, and transplant recipient exposure to the immunosuppressant medication MMF. Find out more about our diagnostics pipeline: https://www.myolaris.com/diagnostics-pipeline

Olaris, Inc

09/04/2026

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