Real-World Evidence Circles

Real-World Evidence Circles Circles: Reimagining and democratizing medical research. Impactful clinical, scientific and financial return on investment.

Ethical intermediation between industry and providers. We license the patented cloud-based software platform necessary to capture, aggregate, analyze and use RWE. That platform integrates the powerful user experience of inCytesโ„ข for physicians and Benchmarcโ„ข for their patients. We also provide the processes enabling physicians and industry to generate clinical, professional and financial value fro

m RWE with minimal burden. Circles-based RWE solutions are turnkey, flexible, and cost effective. They are tailored to the strategic objectives of our clients, and deliver demonstrable and sustained return on investment. They represent a profit center, not a cost center.

AI can generate answers. But can it bear responsibility?As AI becomes more deeply integrated into healthcare and researc...
08/21/2026

AI can generate answers. But can it bear responsibility?

As AI becomes more deeply integrated into healthcare and research, the real question is not how intelligent our systems become, but how accountable they remain. Explore why moral agency must stay human and how federated governance can help ensure transparency, trust, and oversight in an AI-driven future:

Why AI cannot bear moral responsibilityโ€”and how federated governance, human custodianship, and audit trails keep accountability attached to human decisions.

๐—”๐—ป ๐—ผ๐—น๐—ฑ๐—ฒ๐—ฟ ๐—”๐—–๐—Ÿ ๐—ฝ๐—ฎ๐˜๐—ถ๐—ฒ๐—ป๐˜ ๐—ฝ๐—ผ๐—ฝ๐˜‚๐—น๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ฎ๐—ฐ๐—ต๐—ถ๐—ฒ๐˜ƒ๐—ฒ๐—ฑ ๐—ฏ๐—ฒ๐˜๐˜๐—ฒ๐—ฟ ๐—ผ๐˜‚๐˜๐—ฐ๐—ผ๐—บ๐—ฒ๐˜€ ๐˜๐—ต๐—ฎ๐—ป ๐—ฎ ๐˜†๐—ผ๐˜‚๐—ป๐—ด๐—ฒ๐—ฟ ๐—ป๐—ฎ๐˜๐—ถ๐—ผ๐—ป๐—ฎ๐—น ๐—ฟ๐—ฒ๐—ด๐—ถ๐˜€๐˜๐—ฟ๐˜† ๐—ฐ๐—ผ๐—ต๐—ผ๐—ฟ๐˜.That's one of the key i...
08/20/2026

๐—”๐—ป ๐—ผ๐—น๐—ฑ๐—ฒ๐—ฟ ๐—”๐—–๐—Ÿ ๐—ฝ๐—ฎ๐˜๐—ถ๐—ฒ๐—ป๐˜ ๐—ฝ๐—ผ๐—ฝ๐˜‚๐—น๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ฎ๐—ฐ๐—ต๐—ถ๐—ฒ๐˜ƒ๐—ฒ๐—ฑ ๐—ฏ๐—ฒ๐˜๐˜๐—ฒ๐—ฟ ๐—ผ๐˜‚๐˜๐—ฐ๐—ผ๐—บ๐—ฒ๐˜€ ๐˜๐—ต๐—ฎ๐—ป ๐—ฎ ๐˜†๐—ผ๐˜‚๐—ป๐—ด๐—ฒ๐—ฟ ๐—ป๐—ฎ๐˜๐—ถ๐—ผ๐—ป๐—ฎ๐—น ๐—ฟ๐—ฒ๐—ด๐—ถ๐˜€๐˜๐—ฟ๐˜† ๐—ฐ๐—ผ๐—ต๐—ผ๐—ฟ๐˜.

That's one of the key insights emerging from a comparison between ๐——๐—ฟ. ๐—š๐—ผ๐—ฟ๐—ฑ๐—ผ๐—ป ๐— ๐—ฎ๐—ฐ๐—ธ๐—ฎ๐˜†'๐˜€ ๐—œ๐—ป๐˜๐—ฒ๐—ฟ๐—ป๐—ฎ๐—น๐—•๐—ฟ๐—ฎ๐—ฐ๐—ฒโ„ข ๐—”๐—–๐—Ÿ ๐—ฅ๐—ฒ๐—ด๐—ถ๐˜€๐˜๐—ฟ๐˜† ๐—ฎ๐—ป๐—ฑ ๐˜๐—ต๐—ฒ ๐—ฆ๐˜„๐—ฒ๐—ฑ๐—ถ๐˜€๐—ต ๐—ฐ๐—ผ๐—ต๐—ผ๐—ฟ๐˜ ๐—ผ๐—ณ ๐˜๐—ต๐—ฒ ๐—ฆ๐—ฐ๐—ฎ๐—ป๐—ฑ๐—ถ๐—ป๐—ฎ๐˜ƒ๐—ถ๐—ฎ๐—ป ๐—ž๐—ป๐—ฒ๐—ฒ ๐—Ÿ๐—ถ๐—ด๐—ฎ๐—บ๐—ฒ๐—ป๐˜ ๐—ฅ๐—ฒ๐—ด๐—ถ๐˜€๐˜๐—ฟ๐˜† (n=7,331).

To ensure a fair comparison, the analysis focused exclusively on ๐˜ช๐˜ด๐˜ฐ๐˜ญ๐˜ข๐˜ต๐˜ฆ๐˜ฅ ๐˜ˆ๐˜Š๐˜“ ๐˜ณ๐˜ฆ๐˜ค๐˜ฐ๐˜ฏ๐˜ด๐˜ต๐˜ณ๐˜ถ๐˜ค๐˜ต๐˜ช๐˜ฐ๐˜ฏ๐˜ด, excluding multi-procedure cases.

The findings were notable:

โœ… InternalBraceโ„ข cohort median age: ๐Ÿฐ๐Ÿณ ๐˜†๐—ฒ๐—ฎ๐—ฟ๐˜€

โœ… Swedish registry cohort median age: ๐Ÿฎ๐Ÿฑ ๐˜†๐—ฒ๐—ฎ๐—ฟ๐˜€

โœ… KOOS Quality of Life at 1 year: ๐Ÿฒ๐Ÿฏ.๐Ÿญ ๐˜ƒ๐˜€ ๐Ÿฒ๐Ÿฌ.๐Ÿฌ

โœ… KOOS Quality of Life at 2 years: ๐Ÿฒ๐Ÿณ.๐Ÿฌ ๐˜ƒ๐˜€ ๐Ÿฒ๐Ÿฎ.๐Ÿฌ

The InternalBraceโ„ข cohort also exceeded the established ๐—ฃ๐—ฎ๐˜๐—ถ๐—ฒ๐—ป๐˜ ๐—”๐—ฐ๐—ฐ๐—ฒ๐—ฝ๐˜๐—ฎ๐—ฏ๐—น๐—ฒ ๐—ฆ๐˜†๐—บ๐—ฝ๐˜๐—ผ๐—บ ๐—ฆ๐˜๐—ฎ๐˜๐—ฒ (๐—ฃ๐—”๐—ฆ๐—ฆ) threshold by Year 1 and continued to improve through long-term follow-up.

But perhaps the most important takeaway is not just the outcome difference.

Traditional national registries typically assess patients at baseline, 1 year, and 2 years. By capturing additional data at ๐Ÿฏ ๐—ฎ๐—ป๐—ฑ ๐Ÿฒ ๐—บ๐—ผ๐—ป๐˜๐—ต๐˜€, Dr. Mackay's registry provides visibility into the period where recovery accelerates, rehabilitation strategies evolve, and return-to-play decisions are often made.

This is where creates value.

For clinicians, researchers, and innovators, more granular outcome tracking can reveal recovery patterns that annual assessments simply cannot capture.

As healthcare increasingly shifts toward outcomes-based decision-making, robust real-world registries will play an essential role in validating technologies, optimizing patient care, and demonstrating clinical value.

Interested in using real-world evidence to evaluate your surgical protocol, medical device, or biologic therapy? Let's connect.

๐—ช๐—ต๐—ผ ๐˜„๐—ถ๐—น๐—น ๐—ฐ๐—ฎ๐—ฝ๐˜๐˜‚๐—ฟ๐—ฒ ๐˜๐—ต๐—ฒ ๐˜ƒ๐—ฎ๐—น๐˜‚๐—ฒ ๐—ถ๐—ป ๐—ฎ $๐Ÿญ๐Ÿฎ ๐—ฏ๐—ถ๐—น๐—น๐—ถ๐—ผ๐—ป ๐—ฅ๐—ช๐—˜ ๐—บ๐—ฎ๐—ฟ๐—ธ๐—ฒ๐˜?  is rapidly becoming a strategic asset across healthcare and lif...
08/19/2026

๐—ช๐—ต๐—ผ ๐˜„๐—ถ๐—น๐—น ๐—ฐ๐—ฎ๐—ฝ๐˜๐˜‚๐—ฟ๐—ฒ ๐˜๐—ต๐—ฒ ๐˜ƒ๐—ฎ๐—น๐˜‚๐—ฒ ๐—ถ๐—ป ๐—ฎ $๐Ÿญ๐Ÿฎ ๐—ฏ๐—ถ๐—น๐—น๐—ถ๐—ผ๐—ป ๐—ฅ๐—ช๐—˜ ๐—บ๐—ฎ๐—ฟ๐—ธ๐—ฒ๐˜?

is rapidly becoming a strategic asset across healthcare and life sciences. Our article examines the forces driving growth, the opportunities emerging across the ecosystem, and what organizations should be watching as the market evolves toward 2035.

Read the full article:

$12B RWE market projections for 2035. Learn how Circle Datasets navigate the shift to cloud-based post-market surveillance with federated, regulatory-ready data.

CMS has closed the chapter on voluntary value-based care.With TEAM moving forward, and the nationwide expansion of manda...
08/18/2026

CMS has closed the chapter on voluntary value-based care.

With TEAM moving forward, and the nationwide expansion of mandatory CJR-X compliance beginning in January of 2028, hospitals are entering a new financial and assumption-of-risk reality. They are no longer reimbursed on a fee-for-service basis. Rather, they will be financially accountable for the entire 30 (TEAM) or 90 (CJR-X) episode of care, regardless of whether they or third parties provide that care.

That changes everything.

For many health systems, the biggest challenge won't be clinical excellence. It will be managing financial risk across a complex network of post-acute providers, including independent surgical groups, physical therapy partners, and community-based care settings they don't directly control.

In effect, hospitals are being asked to think more like payers while continuing to operate as providers. Yet many organizations are still relying on infrastructure built for retrospective reporting rather than prospective risk management.

Three risks stand out:

1. Risk adjustment starts at the point of care

Financial performance under depends on accurately capturing patient complexity when care is delivered. Once critical clinical information is missed, retrospective reviews and brute-force big data algorithms are structurally unable to to recover it.

2. Quality performance is now a financial performance issue

Cost reduction alone is not enough. Organizations failing to meet quality requirements and long-term outcomes capture thresholds risk leaving significant reimbursement opportunities on the table, regardless of how effectively they manage spending.

3. Governance matters as much as analytics

As hospitals deepen collaboration with physicians and external care partners, transparency becomes essential. Financial incentives, quality outcomes, and operational performance must be linked through auditable and defensible processes.

So what must accountable hospitals do differently? They must shift from retrospective EMR and claims reporting to prospective governance. This includes:

โ€ข Embedding data capture directly into clinical workflows

โ€ข Aligning finance, operations, and clinical leaders around shared accountability

โ€ข Creating trusted frameworks for collaboration across care settings

โ€ข Building audit-ready governance models that support both compliance and performance

The organizations that succeed under and won't be the ones with the most reports. They'll be the ones that can turn clinical data into action before risk becomes reality.

The question for healthcare leaders is no longer whether is coming.

It's whether their organization is equipped to manage it.

Learn more: https://www.rgnmed.com/post/underwriting-the-episode-of-care-the-cms-mandated-transititon-to-hospital-managed-actuarial-risk

CJR-X and TEAM shift episode-level actuarial risk to hospitals, requiring new ways to manage risk adjustment, post-acute costs, and quality performance.

Smoking cessation may be one of the most underutilized tools in   today.Emerging evidence shows that patients who quit s...
08/17/2026

Smoking cessation may be one of the most underutilized tools in today.

Emerging evidence shows that patients who quit smoking after a cancer diagnosis can reduce cancer-related mortality by up to 26%, a survival benefit that rivals many high-cost interventions. The question is no longer whether cessation matters, but how healthcare organizations can systematically integrate it into pathways.

Read how oncology leaders are turning a diagnosis into a powerful opportunity to improve : https://www.rgnmed.com/post/oncology-and-the-teachable-moment-leveraging-smoking-cessation-for-survival-gains

Smoking cessation at cancer diagnosis can cut mortality by up to 26%. Learn how oncology programs can engineer survival gains under CMS ACCESS.

08/13/2026

Healthcare has more data than ever before.

Yet as , , and advanced analytics become critical to decision-making, one challenge is becoming impossible to ignore:

๐—›๐—ผ๐˜„ ๐—ฑ๐—ผ ๐˜„๐—ฒ ๐—ธ๐—ป๐—ผ๐˜„ ๐˜๐—ต๐—ฒ ๐—ฑ๐—ฎ๐˜๐—ฎ ๐˜„๐—ฒ ๐—ฟ๐—ฒ๐—น๐˜† ๐—ผ๐—ป ๐—ฟ๐—ฒ๐—ณ๐—น๐—ฒ๐—ฐ๐˜๐˜€ ๐—ฟ๐—ฒ๐—ฎ๐—น๐—ถ๐˜๐˜†?

In this expert perspective, we explore why ground truth is emerging as a foundational requirement for generating trusted evidence, advancing innovation, and improving healthcare outcomes.

For healthcare leaders, researchers, and innovators, this is more than a technical discussion. It is a strategic conversation about confidence, credibility, and the future of evidence generation.

Read the full article: https://www.rgnmed.com/post/architecting-ground-truth

08/12/2026

Are we adequately preparing the next generation of clinical investigators, or simply teaching them how to navigate increasingly complex research systems?

As healthcare and organizations work to accelerate innovation, a critical question is emerging: What happens when takes a back seat to administration, compliance, and career metrics?

The answer may have far-reaching implications for research quality, scientific leadership, and ultimately, patient outcomes.

This expert perspective explores why developing strong investigators requires more than funding and training programs, and what healthcare organizations can do to strengthen the future of clinical science.

A timely read for healthcare providers, clinical researchers, academic leaders, and industry stakeholders: https://www.rgnmed.com/post/re-socializing-young-investigators

Global   is facing a new reality: stricter data residency requirements, increasing privacy expectations, and growing ope...
08/11/2026

Global is facing a new reality: stricter data residency requirements, increasing privacy expectations, and growing operational complexity.

How can organizations maintain compliance without slowing innovation?

Our article explores how federated data capture is helping research teams manage global data challenges while supporting efficient, scalable study ex*****on: https://hubs.li/Q04szx6C0

Navigate global data residency with Federated Data Capture. Learn how Circle Datasets use decentralized storage and Self-Sovereign Identity to ensure privacy compliance and secure research.

๐ƒ๐ข๐ ๐ข๐ญ๐š๐ฅ ๐ข๐๐ž๐ง๐ญ๐ข๐ญ๐ฒ ๐ข๐ฌ ๐๐ฎ๐ž ๐Ÿ๐จ๐ซ ๐š ๐ญ๐ซ๐š๐ง๐ฌ๐Ÿ๐จ๐ซ๐ฆ๐š๐ญ๐ข๐จ๐ง.As organizations face growing identity breach risks, emerging technologies ...
08/10/2026

๐ƒ๐ข๐ ๐ข๐ญ๐š๐ฅ ๐ข๐๐ž๐ง๐ญ๐ข๐ญ๐ฒ ๐ข๐ฌ ๐๐ฎ๐ž ๐Ÿ๐จ๐ซ ๐š ๐ญ๐ซ๐š๐ง๐ฌ๐Ÿ๐จ๐ซ๐ฆ๐š๐ญ๐ข๐จ๐ง.

As organizations face growing identity breach risks, emerging technologies like Self-Sovereign Identity (SSI) and Zero-Knowledge Proofs are redefining how trust, privacy, and security can coexist.

Learn how these innovations can help reduce exposure of sensitive data while strengthening digital trust.

Read the full article:

Healthcare data security via Self-Sovereign Identity. Learn how Circle Datasets use Zero-Knowledge Proofs and private keys to minimize breach risks and ensure global privacy compliance.

Who truly controls healthcare data?The answer may not lie in ownership, but in consent.Our latest article examines how a...
08/07/2026

Who truly controls healthcare data?

The answer may not lie in ownership, but in consent.

Our latest article examines how a well-designed consent framework can strengthen trust, support innovation, and redefine the relationship between patients, physicians, and data.

Read more:

Embedding consent into system architecture transforms permission from static forms into dynamic, executable, and continuously verifiable process.

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