Cohen-Eisenberg Laboratory

09/04/2026

It was great having Matthew in the lab this summer. Good luck in grad school!

07/17/2026

As the Montreal meeting comes to a close... next stop, Fort Collins, Colorado ⛰️

07/17/2026

Fireworks on the Montreal waterfront

07/17/2026

06/25/2026

Congratulations to Lauren and everyone who worked on the paper, "HSV-2 gC mRNA immunization in mice protects by producing antibodies that bind immune evasion epitopes," out now in PLOS Pathogens!

Author summary Our goal is to develop a vaccine to prevent ge***al herpes. Our strategy is to include important viral proteins in the vaccine that enable entry, but also viral proteins that dampen host immune responses. Often, entry proteins like glycoproteins B and D of HSV-2 (gB2, gD2) are selecte...

05/11/2026

Congratulations to Doina and everyone who worked on the paper, "Bispecific antibodies targeting herpes simplex virus glycoproteins B and D," now available online!

BackgroundHerpes simplex viruses (HSV-1 and HSV-2) can be transmitted both orally and sexually and cause lifelong morbidity and, in some cases, meningitis an...

04/30/2026

Good luck at Temple Manaswini 🎉

03/26/2026

Congratulations to Giulia and everyone who worked on the paper, "HSV-2 gE2/gI2 are immune evasion molecules that bind IgG Fc to inhibit antibody-dependent cellular cytotoxicity," now available in Frontiers in Immunology!

We conclude that antibodies to gC2/gD2/gE2 are targets of ADCC, that gE2/gI2 inhibits ADCC, and that an mAb that targets the gE2 IgG Fc binding domain can prevent this inhibition.