PK/ADME Consulting, LLC

12/11/2012

R115777, an orally administered (BID) farnesyl transferase inhibitor inhibits its target at nanomolar concentrations but lacked clinical efficacy in metastatic melanoma patients.
http://www.translational-medicine.com/content/10/1/246/abstract

Multiple farnesylated proteins are involved in signal transduction in cancer. Farnesyltransferase inhibitors (FTIs) have been developed as a strategy to inhibit the function of these proteins. As FTIs inhibit proliferation of melanoma cell lines, we undertook a study to assess the impact of a FTI in...

12/11/2012

http://www.translational-medicine.com/content/10/1/245/abstract

Dovitinib is a receptor tyrosine kinase (RTK) inhibitor targeting vascular endothelial growth factor receptors, fibroblast growth factor receptors and platelet-derived growth factor receptor beta. Dovitinib is currently in clinical trials for the treatment of hepatocellular carcinoma (HCC).

09/16/2012

http://www.translational-medicine.com/content/10/1/190/abstract

Substantial advances have been generated in understanding the pathogenesis of rheumatoid arthritis (RA). Current murine models of RA-like disease have provided great insights into the molecular mechanism of inflammatory arthritis due to the use of genetically deficient or transgenic mice. However, t...

08/15/2012

https://www.scienceexchange.com/reproducibility

The Reproducibility Initiative helps researchers outsource their study for validation with expert providers at core facilities and commercial research organizations.

06/10/2012

Here is an approach to predict which P-gp and/or CYP 3A4 substrates may follow linear absorption kinetics.http://www.springerlink.com/content/e56rh32257085530/

In Vitro Techniques to Study Drug–Drug Interactions Involving Transport: Caco-2 Model for Study of P-Glycoprotein and Other Transporters

06/10/2012

A novel method to scale clearance across the human life-span.
http://www.springerlink.com/content/j5k3843570w16v8u/

Chenguang Wang, Mariska Y. M. Peeters, Karel Allegaert, Heleen J. Blussé van Oud-Alblas, Elke H. J. Krekels, Dick Tibboel, Meindert Danhof and Catherijne A. J. Knibbe

04/30/2012

Randomized Controlled Clinical trials don't support the public belief that supplements provide cancer protection. To the contrary, some antioxidant may increase cancer risk.
http://www.ncbi.nlm.nih.gov/pubmed/22534785

PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

04/16/2012

http://www.ncbi.nlm.nih.gov/pubmed/22378269

PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

04/09/2012

http://www.ncbi.nlm.nih.gov/pubmed?term=recent%20advances%20in%20the%20study%20on%20resveratrol

PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

03/28/2012

A longitudinal study utilizing Integrative Personal Omics Profiling (iPOP) revealed activation of molecular events following viral infection and disease onset. The learnings point to a need for integration of genomics with proteonomics.

Cell, Volume 148, Issue 6, Pages 1293-1307, Publication Date 16 March 2012Copyright © 2012 Elsevier Inc. All rights reserved. DOI: 10.1016/j.cell.2012.02.009

03/27/2012

OCT1 seems to be downregulated in hepatocellular carcinoma. The relevance for tumor treatment is not clear yet and should be investigated.

03/22/2012

Different regions of a tumor had good or bad prognostic markers. This intratumor heterogeneity poses grave challenges to personalized medicine and biomarker selection.