MD Bioproducts

10/28/2025

MD Bioproducts provides premium research tools for cancer immunotherapy, a rapidly evolving field that aims to use the immune system to fight cancer. These products facilitate research into various immunotherapies, such as CAR T cells and checkpoint inhibitors.

These resources enable scientists to investigate the role of cytokines in tumor suppression, the regulation of immune checkpoints, and methods to sustain anti-cancer immune responses, driving progress in immune-oncology research.

Cancer Immunotherapy Products: https://www.mdbioproducts.com/collections/cancerimmunotherapy

10/21/2025

Strengthening Immunology Research with precision and quality!

Find out more about our products here:
https://www.mdbioproducts.com/collections/immunology

10/14/2025

Premium solutions for your Neurology Research advancements!

Check out our Disease Induction Reagents:
https://www.mdbioproducts.com/collections/neurology

10/07/2025

Quality products that contribute to your Inflammation Research success!

Visit our Arthritis products for in vivo & in vitro applications:
https://www.mdbioproducts.com/collections/arthritis

09/23/2025

With MD Bioproducts ArthritoMab™ Antibody Cocktail, researchers can utilize a rapid 12-day arthritis model to conserve resources, free up animal facility space, and meet project deadlines. This approach offers several advantages over the traditional CIA and K/BxN models, including:
- Rapid disease onset within 24-48 hours.
- Reduced study duration, requiring fewer resources and freeing up animal facility space.
- Synchronized disease progression simplifies administration schedules and data analysis.
- 100% incidence reduces the required group size.
- Consistent inflammation at both clinical and histological levels.
- Susceptibility in various mice strains.

Download the Whitepaper to learn more:
https://www.mdbioproducts.com/pages/arthritomab-antibody-cocktail-whitepaper

09/16/2025

High-Purity Collagen Type II for Consistent CIA Models

Ensure reproducibility in Collagen-Induced Arthritis (CIA) studies with MD Bioproducts highly purified (>98%) Collagen Type II. Available in both bovine and chicken sources, our collagen is offered in lyophilized and solution formats—ideal for preclinical research in autoimmune and inflammatory diseases.

🔬Explore our full range of disease induction reagents for Collagen-Induced Arthritis model: https://www.mdbioproducts.com/pages/collagen-induced-arthritis

Featured Products:
- Catalog/SKU: 804001-Lyo
Bovine Collagen Type II, Immunization Grade, Lyophilized, 10 mg
- Catalog/SKU: 804001-Sol
Bovine Collagen Type II, Immunization Grade, Solution, 5 mL/vial (2 mg/mL)
- Catalog/SKU: 804002-Lyo
Chicken Collagen Type II, Immunization Grade, Lyophilized, 10 mg
- Catalog/SKU: 804002-Sol
Chicken Collagen Type II, Immunization Grade, Solution, 5 mL (2 mg/mL)

MD Bioproducts is a trusted global supplier of Collagen Type II for research use—supporting reliable arthritis research and autoimmune disease modeling in preclinical environments.

09/11/2025

New study led by Dr. Denggang Fu and Dr. Sophie Paczesny at the Medical University of South Carolina (MUSC) reveals how leukemia stem cells (LSCs) drive both disease progression and resistance to treatment.

The research indicates that LSCs establish a self-sustaining loop through IL-33/IL-1RL1 signaling, enabling them to survive while shaping a suppressive immune environment in the bone marrow. This loop not only fuels leukemia growth but also shields it from the body’s defenses.

IL1RL1 emerges as a promising therapeutic target in acute myeloid leukemia (AML), with potential for next-generation bispecific antibody immunotherapies that can disrupt this vicious cycle.

In this study, the Monoclonal Antibody to Mouse T1/ST2, PE (Product Code: 101001PE) from MD Bioproducts was used to identify critical immune cell populations within the leukemic niche.

Authors:
Denggang Fu, Hua Jiang, Alan Long, Ella Harris, Hongfen Guo, Maegan L. Capitano, John Wrangle, Joshua R. Faust, Anilkumar Gopalakrishnapillai, Santhosh Kumar Pasupuleti, Ramdas Baskar, Reuben Kapur, Sonali Barwe, Nai-Kong V. Cheung & Sophie Paczesny

Find out more about their important study featured in the publication here:
https://www.mdbioproducts.com/blogs/news/featured-publication-in-focus-dual-targeting-of-tumoral-cells-and-immune-microenvironment-by-blocking-the-il-33-il1rl1-pathway

Product Link:
https://www.mdbioproducts.com/products/t1-st2-il-33-r-mouse-monoclonal-antibody-pe-conjugated?_pos=1&_sid=8ed07e665&_ss=r&variant=39848199815357

Also visit our products for Cancer Immunotherapy research:
https://www.mdbioproducts.com/collections/cancerimmunotherapy

Authors: Denggang Fu, Hua Jiang, Alan Long, Ella Harris, Hongfen Guo, Maegan L. Capitano, John Wrangle, Joshua R. Faust, Anilkumar Gopalakrishnapillai, Santhosh Kumar Pasupuleti, Baskar Ramdas, Reuben Kapur, Sonali P. Barwe,Nai-Kong V. Cheung & Sophie Paczesny Department of Microbiology and Immu...

09/09/2025

Freund’s Adjuvant remains one of the most widely used adjuvants in research, supporting scientists in generating robust and reproducible immune responses.

MD Bioproducts’ Complete Freund’s Adjuvant (CFA) is in mineral oil emulsion containing heat-killed Mycobacterium tuberculosis at 4mg/ml. Its formulation is designed to enhance immune response in both in vivo/in vitro studies.

At MD Bioproducts, we are committed to providing reliable tools that empower research studies.

Product Link:
https://www.mdbioproducts.com/products/complete-freund-adjuvant?_pos=2&_sid=e4707ce42&_ss=r&variant=39848196636861

Our Line of Disease Induction Reagents:
https://www.mdbioproducts.com/collections/disease-induction-reagents

09/04/2025

Can two treatments work better together to protect the kidneys in diabetes? That’s what a team of researchers from Université Bourgogne Europe and INSERM in Dijon, France, led by Océane Pointeau and Tony Jourdan, set out to explore.

They studied diabetic nephropathy (DN), a kidney disease caused by diabetes. The team tested a combination of two known therapies:

Empagliflozin, a medicine used to lower blood sugar
Monlunabant, a compound that blocks CB1 receptors, which are involved in inflammation and kidney damage

They treated diabetic mice with each compound alone or in combination. The combo therapy worked best, showing stronger protection against kidney damage, inflammation, and fibrosis (scarring of kidney tissue).

To support their findings, the team measured Uromodulin (UMOD, THP) levels in urine, a key biomarker of kidney health, using the MD Bioproducts Uromodulin ELISA kit (UMOD, THP).

This study demonstrates that targeting both blood sugar control and inflammation pathways may provide more effective protection for the kidneys in diabetic patients.

Authors:
Océane Pointeau, AWA ISMA BA, Audrey GEISSLER, Romain Barbosa, Abhishek Basu, Muhammad Arif, Marina Nivot, Maéva LORIOT, Julia Leemput, Patricia Passilly-Degrace, Sebastien Causse, Laurent DEMIZIEUX, Hélène François, Bruno Vergès, Dr. Jianmin Duan, Genevieve Gaucher, Michael Harvey, Pascal Degrace, Glenn C., RESAT CINAR, BPharm, PhD, MBA and Tony Jourdan

Find out more about their important study featured in the publication here:
https://www.mdbioproducts.com/blogs/news/featured-publication-in-focus-blockade-of-cannabinoid-cb1-receptors-potentiates-the-anti-fibrotic-effects-mediated-by-sglt2-inhibition-in-a-mouse-model-of-diabetic-nephropathy

Product Link:
https://www.mdbioproducts.com/products/monelisa-uromodulin-glycoprotein-thp-elisa?_pos=1&_sid=1cfbc3217&_ss=r&variant=39848199946429

Authors: Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly-Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pas...

09/02/2025

The MD Bioproducts Uromodulin (UMOD, THP) ELISA is a 96-well assay designed to accurately quantify Uromodulin levels in urine, plasma, and serum. This biomarker is essential for assessing kidney function, cardiovascular health, and metabolic disorders. The Uromodulin assay serves as a supporting tool for clinical studies and supports research related to acute kidney injury (AKI), chronic kidney disease (CKD), cardiovascular disease (CVD), and metabolic disorders.

High Sensitivity: Detects Uromodulin at

08/28/2025

A research team led by Chihiro Hara-Tsuchiya at Astellas Pharma Inc., Japan, has developed a novel screening system to identify compounds that regulate type 2 innate lymphoid cells (ILC2s) cells known to contribute to allergic diseases through the production of IL-4, IL-5, and IL-13.

Study findings:
- A high-throughput screening of ~30,000 compounds led to the discovery of AS4040605, a small molecule that inhibits both mouse and human ILC2 activity.
- The compound targets retinoic acid receptor-α (RARα) and may act as an inverse agonist.
- A robust IL-5 assay system was established using IL-2 + IL-33-stimulated mouse lung ILC2s.
- This approach offers a promising direction for developing future therapies against allergic diseases.

Throughout the study, mouse ILC2s were characterized using the Monoclonal Antibody to Mouse T1/ST2, FITC (Product code: 101001F) from MD Bioproducts.

This work highlights the value of functional screening systems in identifying novel immunoregulatory compounds and suggests that RARα inverse agonism is a viable therapeutic mechanism.

Authors:
Chihiro Hara-Tsuchiya, Satoru Ujihara, Sho-ichi Hirose, Yukihiro Kitanaga, Katsuma Jono and Haruna Sasaki-Iwaoka

Find out more about their important study featured in the publication here:
https://www.mdbioproducts.com/blogs/news/featured-publication-in-focus-a-novel-retinoic-acid-receptor-%CE%B1-inhibitor-as4040605-inhibits-ilc2-activity

Product Link:
https://www.mdbioproducts.com/products/t1-st2-il-33r-mouse-monoclonal-antibody-fitc?_pos=1&_sid=72d338b87&_ss=r&variant=39848199848125

Authors: Chihiro Hara-Tsuchiya, Satoru Ujihara, Sho-ichi Hirose, Yukihiro Kitanaga, Katsuma Jono and Haruna Sasaki-Iwaoka Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan European Journal of Pharmacology. Elsevier ---------------------- Product referenced: Catalogue # 1010...

08/26/2025

MD Bioproducts Anti-Mouse IgD Antiserum is a high-quality B cell activator suitable for both in vivo and in vitro research applications. This product specifically targets B cells, enabling proliferation, differentiation, and immune tolerance studies. In research using BALB/c mice, the product demonstrates a three-fold increase in CD86+ peripheral B cells within three hours of injection, confirming strong and immediate B cell activationMD Bioproducts Anti-Mouse IgD Antiserum provides a reliable solution for researchers looking to enhance their understanding of B cell biology and immune function.

Product Link: https://www.mdbioproducts.com/products/goat-anti-mouse-igd-antiserum?_pos=3&_sid=d56deec29&_ss=r&variant=39848196702397