Tenaya Therapeutics

Tenaya Therapeutics We discover and develop genetic medicines to improve the lives of people with heart conditions. At Tenaya, we believe we can do better. audiences.

Heart conditions come in many forms, affecting individuals of all ages and backgrounds. Yet often, treatments have taken a one-size-fits-all approach, with a few commonly used medicines prescribed to manage symptoms. Tenaya is 100% committed to discovering and developing new medicines for heart conditions. We hope to not just alleviate symptoms, but to change the course of disease by targeting its

underlying genetic causes. Founded by leading researchers specializing in genetic medicines, rare diseases and the biology of the heart, Tenaya built specialized capabilities to translate our scientific insights into new treatments. We are currently advancing a pipeline of investigational therapeutics with the potential to transform and extend the lives of patients. Tenaya was founded by leading cardiovascular scientists and we work to incorporate the patient community voice in everything we do. Wendy Borsari, our Associate Director of Patient Advocacy, lives with hypertrophic cardiomyopathy (HCM). We also formed a Patient Advisory Council (PAC) of community members with cardiomyopathies in 2022 so that we could learn directly from people with these conditions early and often. We meet with this group of 12 individuals regularly to obtain input on study design, educational materials, and unmet needs of the patient community. This page is sponsored by Tenaya Therapeutics. Please note that certain content on our page is intended for U.S. Tenaya’s gene therapies are investigational and have not been approved by the U.S. Food and Drug Administration (FDA) or any other countries’ health authority or regulatory agency.

Histone deacetylases, also known as HDACs, are enzymes that regulate cellular processes and gene expression. Pan-HDAC in...
09/02/2026

Histone deacetylases, also known as HDACs, are enzymes that regulate cellular processes and gene expression.

Pan-HDAC inhibition, a common approach to blocking multiple HDACs at once, have been associated with side effects including abnormally low platelets (thrombocytopenia) and increased risk of prolonged intervals between heartbeats (QT prolongation), which can predispose patients to life-threatening arrhythmias.

In preclinical and Phase 1 safety studies, Tenaya’s highly selective HDAC6 inhibitor did not result in such side effects, and may provide safety advantages, allowing for higher dosing to maximize efficacy.

Learn more about HDAC6 inhibition and TN-301, our highly selective HDAC6 inhibitor, on our website (link in Bio).

09/01/2026

Knowledge empowers patients and families.

This video from Charged explores how to navigate life with hypertrophic cardiomyopathy (HCM)—from understanding the condition to finding support and staying informed.

Whether you're living with HCM, caring for someone who is, or simply interested in learning more, we invite you to watch and share.

We’re incredibly grateful to Alex for spending time with our team and talking about living with ARVC caused by a PKP2 mu...
08/26/2026

We’re incredibly grateful to Alex for spending time with our team and talking about living with ARVC caused by a PKP2 mutation.

After Alex suffered a sudden cardiac arrest while visiting the Faroe Islands, her husband performed CPR, saving her life. Their story is a powerful reminder of the resilience of patients and families facing inherited heart disease.

Hearing firsthand experiences like Alex's reminds us why we do what we do strengthening our commitment to advancing innovative therapies that have the potential to make a meaningful difference for people and families living with genetic heart disease.

Thank you, Alex, for sharing your story, your strength, and your hope. Your voice inspires us every day.

We believe that the patient’s voice matters in drug development, and thankfully much of the industry and regulators shar...
08/25/2026

We believe that the patient’s voice matters in drug development, and thankfully much of the industry and regulators share our belief wholeheartedly.

In clinical trials, patient’s experiences are measured through Patient-Reported Outcomes (PROs)—tools that help researchers understand the impact of disease and treatment from the patient's perspective.

Maybe it's:
• Being able to walk farther
• Having more energy
• Returning to work or school
• Spending more time with family
• Feeling hopeful again

Developing a new therapy is a journey—not a single milestone.Before a medicine reaches patients, it must undergo years o...
08/21/2026

Developing a new therapy is a journey—not a single milestone.

Before a medicine reaches patients, it must undergo years of research, clinical testing, a and review from the FDA of all the product’s safety and efficacy data. Even after approval, the FDA continues to closely monitor medicines for safety and effectiveness.

Every stage of development is designed to protect patients while advancing new treatment options.

Learn more about the drug development process: https://bit.ly/4cF1KH8

Results from our ongoing MyClimb™ natural history study demonstrated that MYBPC3-associated pediatric patients experienc...
08/20/2026

Results from our ongoing MyClimb™ natural history study demonstrated that MYBPC3-associated pediatric patients experience a markedly faster disease progression and cumulative disease burden compared to adult-onset patients. This includes a 36% higher likelihood of developing life-threatening ventricular arrhythmias, and twice the likelihood of requiring a transplant or ventricular assist device.

At Tenaya, we are committed to addressing the underlying causes of MYBPC3-associated HCM.

At Tenaya, we follow the science to uncover innovative therapeutic approaches to heart disease. Our expertise in identif...
08/13/2026

At Tenaya, we follow the science to uncover innovative therapeutic approaches to heart disease.

Our expertise in identification and validation of heart disease targets resulted in our deep and diverse pipeline that includes three clinical-stage therapeutic candidates and multiple pre-clinical assets, as well as our research collaboration with .

Learn more about our programs: https://www.tenayatherapeutics.com/our-programs/

Gene therapy holds the promise of offering a durable, one-time treatment aimed at the underlying genetic cause of a dise...
08/11/2026

Gene therapy holds the promise of offering a durable, one-time treatment aimed at the underlying genetic cause of a disease.

Currently, a person can receive AAV gene therapy only once. It cannot be re-dosed or administered in a larger dose later.

After the first treatment with AAV gene therapy, a person’s immune system makes antibodies to the AAV vector. If the body sees the same AAV again, it will attack it before it has a chance to work.

Learn more: www.hcmstudies.com and www.arvcstudies.com

Therapy

Every clinical trial has an important group working behind the scenes to protect participants: the Institutional Review ...
08/07/2026

Every clinical trial has an important group working behind the scenes to protect participants: the Institutional Review Board (IRB).

An IRB is an independent committee made up of healthcare professionals, scientists, and community members who review research studies before they begin.

Their job is to ask questions like:
• Are participants' rights protected?
• Are the risks reasonable?
• Is the consent form easy to understand?
• Is the study ethical?

Patient safety always comes first.

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171 Oyster Point Boulevard, Ste 500
South San Francisco, CA
94080

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