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Applied BioPhysics Applied BioPhysics manufactures ECIS, a non-invasive automated electrical method to study animal cell behavior in real-time. www.biophysics.com

Creator of ECIS® 😎 Pioneering impedance-based tools for real-time, label-free cell research and drug discovery. Study cells in vitro with precision and ease.

Discover what ECIS® can do! Continuously monitor barrier function in real time!  Plus, explore a complete suite of autom...
10/01/2026

Discover what ECIS® can do! Continuously monitor barrier function in real time! Plus, explore a complete suite of automated, label-free cell assays. 👉

Discover the power of ECIS for continuous, non-invasive cell monitoring. Request a free demo to see real-time cellular event tracking in action.

🔬 Live Webinar: Real-Time Quantitative Analysis of Cell Invasion & Extravasation 🗓️ Tuesday, Sept 29 ⏰ 11:00 AM EDT 🔮 Fe...
09/23/2026

🔬 Live Webinar: Real-Time Quantitative Analysis of Cell Invasion & Extravasation 🗓️ Tuesday, Sept 29 ⏰ 11:00 AM EDT 🔮 Featuring Dr. Charles Keese

Join us as we review how monitors endothelial monolayers challenged by metastatic cell lines. Learn how to track extravasation continuously and label-free to generate precise, automated quantitative data.

Whether you are focusing on cancer biology, vascular research, or drug discovery, this session will show you how to gain deeper kinetic insights from your invasion assays.

👉 Register now to save your seat: https://biophysics.com/webinars.php

Stop missing critical cell behavior between time points! 📈 ® technology provides continuous, label-free quantification o...
08/17/2026

Stop missing critical cell behavior between time points! 📈

® technology provides continuous, label-free quantification of cell attachment, growth, and barrier function in real time.

Discover the power of continuous cell monitoring:
lp.biophysics.com/ECISTech-L

Discover the power of ECIS for continuous, non-invasive cell monitoring. Request a free demo to see real-time cellular event tracking in action.

Track continuous TEER data from 96 wells for hours, days, or weeks—without ever opening your incubator door. 📈🚪The   TEE...
08/06/2026

Track continuous TEER data from 96 wells for hours, days, or weeks—without ever opening your incubator door. 📈🚪

The TEERZ system automates real-time barrier function tracking so you get the full picture, not just isolated snapshots.

👉 Upgrade your lab's workflow: https://biophysics.com/teerZ.php

🥳  research from the University at Albany CNSELed by Fernando Pesantez Torres, this study used ECIS to track how NIH 3T3...
12/10/2025

🥳 research from the University at Albany CNSE

Led by Fernando Pesantez Torres, this study used ECIS to track how NIH 3T3 fibroblasts and bEnd3 endothelial cells respond to SMA nanoparticles in real time.

🧪 Negligible cytotoxicity at all doses
🛡️ High NP levels slightly slowed barrier formation
🔄 Medium change restored barrier function at low doses; high doses remained reduced, likely from NP attachment

The results underscore ECIS as a powerful platform for monitoring cell behavior and guiding the safe design of oxygen-sensitive nanomaterials for biomedical use.

📖 Read the full study: https://pubs.acs.org/doi/10.1021/acsabm.5c01443

Hyperosmolar stress cut corneal barrier integrity by up to 69%—but L-carnitine helped restore function. Using   Z-Theta,...
10/14/2025

Hyperosmolar stress cut corneal barrier integrity by up to 69%—but L-carnitine helped restore function. Using Z-Theta, researchers showed:

🔹NaCl stress reduced TER by 30–69% and slowed migration
🔹 L-carnitine partially rescued TER and improved repair.
🔹 ECIS enabled automated wounding and real-time recovery tracking, outperforming scratch assays.

✨ Findings point to L-carnitine’s therapeutic potential in dry eye disease and the value of in barrier research.

📄Full Paper: 10.1016/j.exer.2025.110499

Using   Z-Theta, researchers tracked how Müller glial cell EVs affect RPE barrier function:🔵Normoxic EVs (blue): Barrier...
10/02/2025

Using Z-Theta, researchers tracked how Müller glial cell EVs affect RPE barrier function:

🔵Normoxic EVs (blue): Barrier stays stable ✅
🟡Hypoxic EVs (yellow): Barrier weakens quickly, TER drops over 72h ⚠️

💡 Label-free, real-time monitoring shows how hypoxic EVs compromise retinal integrity—critical for diseases like diabetic retinopathy.

📄Full paper: https://www.mdpi.com/2079-7737/14/8/1014 #

Insulin-regulated palmitoylation plays a crucial role in maintaining the integrity of lymphatic endothelial cell (LEC) b...
08/27/2025

Insulin-regulated palmitoylation plays a crucial role in maintaining the integrity of lymphatic endothelial cell (LEC) barriers. Researchers at Saint Louis University used to continuously monitor TEER in real-time under incubation conditions, revealing how changes in palmitoylation profiles directly affect LEC permeability and stability.

🔗 Study: https://lnkd.in/gu9sdwqJ
ℹ️About ECIS: https://lnkd.in/gEqFH5Bt

In Loving Memory of Dr. Ivar Giaever (1929–2025)It is with heavy hearts that we share the news of the passing of Dr. Iva...
07/10/2025

In Loving Memory of Dr. Ivar Giaever (1929–2025)

It is with heavy hearts that we share the news of the passing of Dr. Ivar Giaever. Ivar passed away peacefully on June 20, 2025, at the age of 96, surrounded by his family.

Ivar was not only a Nobel Laureate in Physics—recognized in 1973 for his pioneering work in superconductivity—but also a visionary who brought that same spirit of curiosity and innovation to the life sciences. His work led to the development of Electric Cell-substrate Impedance Sensing (ECIS), a groundbreaking method for studying living cells in real time using electrical currents—without labels or dyes.

In 1991, he co-founded Applied BioPhysics with the mission of sharing ECIS technology with the broader research community. Thanks to his leadership and vision, ECIS has become a trusted tool in labs around the world, helping to advance cancer research, drug development, toxicology, and countless other areas of science.

To those of us who had the privilege of working with him, Ivar was more than a brilliant scientist—he was a kind, witty, and inspiring presence. He challenged us to think differently, to question everything, and to approach science with both rigor and imagination. His mentorship, humor, and boundless energy shaped the culture of our company and left a lasting impact on all of us.
We will miss him deeply, but we carry forward his legacy every day—in our work, our values, and our commitment to supporting the scientists he cared so deeply about.

Our thoughts are with his family, friends, and all who were touched by his extraordinary life.

05/16/2025

🎉Applied BioPhysics, Inc. turns 34 today! 🎈 Thanks to everyone who's been part of the ride. Let’s keep pushing science forward!🚀

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