06/05/2026
“Recently, another important side effect has been detected and this one is of particular interest to athletes. Data presented at the American Academy of Orthopedic Surgeons Annual Meeting reported on patients with obesity with or without diabetes, using GLP-1 agonists who were found to have statistically significantly increased rates of injuries to tendons. Tears of the rotator cuff, Achilles tendon, peroneal tendon (a tendon of the calf), and pectoralis tendon were all seen at a rate about 50% higher than in those not taking these drugs.
It is important to note that while the risk of tendon rupture was about 1.5 times higher for those who were taking GLP-1 receptor agonists than for those who were not, that risk was still very low. About 0.3% for Achilles tendon rupture (vs. 0.2%), 2.4% for rotator cuff (vs. 1.5%) and 0.8% for rupture of the pectoralis tendon (vs. 0.5%). So, this is not an epidemic of tendon injuries. Still, the increase is real.”
New data reveals that the widely used weight-loss drugs GLP-1 receptor agonists are associated with a significantly increased risk of serious tendon injuries - a concerning finding for endurance athletes using the medication, says Dr. Jeffrey Sankoff.