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Sielc Technologies, Inc.

Name: Sielc Technologies, Inc.
Address: 804 Seton Court, Wheeling, IL, 60090, US
Telephone: +18472292629
Price range: $$

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United States
Wheeling, IL
Sielc Technologies, Inc.

Innovating for scientists, educators, and industries worldwide.

Experts in liquid chromatography, offering advanced HPLC devices, high-performance columns, and free method development to streamline research and deliver reliable results.

05/01/2026

🔬 Preparative HPLC Without Uncertainty
Scaling from analytical to preparative chromatography is often where challenges begin.
Loss of resolution, unpredictable behavior, and inefficient purification can slow down entire workflows.

SIELC preparative HPLC services are designed to eliminate that gap — ensuring reliable purification and predictable scale-up from the very start.
🔹 Built for real separation challenges
We support compound purification, impurity isolation, and analytical-to-preparative method transfer using a wide range of stationary phases:
• Reversed-phase
• Normal-phase
• HILIC
• Mixed-mode
From 5 mg to 1000 mg, our approach ensures controlled, reproducible results across different compound types.

🔹 Complete preparative infrastructure
Our platform is equipped for full-cycle purification:
• Preparative columns up to 50 mm ID (manufactured in-house)
• Flow rates up to 200 mL/min
• Manual and automated injection systems
• UV, RI, and MS detection
• Fraction collection and post-processing
Each column is quality-controlled and shipped with an original chromatogram to guarantee performance.
✅ Predictable scale-up
Seamless transition from analytical methods to preparative purification
✅ Controlled impurity isolation
Reliable separation for structure identification and further studies
✅ Flexible project support

Methods adapted to client samples and specific requirements
Whether you are isolating impurities, purifying target compounds, or working with complex mixtures and isomers — SIELC provides a structured and reliable workflow.

👉 Learn more: https://sielc.com/prep
👉 Contact us to discuss your project: [email protected]

04/24/2026

🔧 Stop Searching for the Right Adapter
In chromatography and analytical lab work, the required connection is not always readily available. Different tubing sizes and fitting standards often turn a simple setup into a frustrating search.
The Universal Adapter Kit eliminates this problem by allowing you to quickly assemble the required connection from a compact set of fully compatible components.
It simplifies tubing connections in analytical laboratories, making it easy to interface between 10-32, ¼-28, Luer, barb, and NPT fittings across multiple tubing diameters.

🔹 Built for real laboratory work
Instead of maintaining a large inventory of individual fittings, this kit provides a flexible, ready-to-use solution for everyday lab setups.
• Build 40+ connection configurations from a compact set of components
• Compatible with 1/16”, 1/8”, and 1/4” tubing
• Suitable for both low- and high-pressure applications
• Made from PEEK, PTFE, and stainless steel 316
The kit includes all essential components for quick assembly, along with tools to ensure secure and leak-free connections.

✅ Modular, interchangeable design
Quick assembly and easy reconfiguration
✅ Broad compatibility
Supports common lab standards and multiple tubing sizes
✅ Built for real lab conditions
Durable, leak-free, and reliable connections

👉 Learn more: https://sielc.com/universal-adapters-kit
👉 Request a quote: [email protected]

03/17/2026

SIELC Technologies Expands Full HPLC Portfolio Across Africa, the Middle East, and Central Asia

We’re pleased to announce that SIELC Technologies has entered into a collaboration with Alliance Global FZ LLC (AGBL) to expand access to HPLC solutions across Africa, the Middle East, Turkey, Pakistan, and Central Asia.

The collaboration covers the following countries:
Morocco, Tunisia, Algeria, Egypt, Nigeria, Ghana, Uganda, Kenya, South Africa, Kingdom of Saudi Arabia (KSA), United Arab Emirates (UAE), Qatar, Jordan, Lebanon, Turkey, Pakistan, Kazakhstan, Uzbekistan, Turkmenistan, Kyrgyzstan, and Tajikistan.

AGBL will support regional distribution and customer engagement for SIELC’s full chromatography portfolio, including:
• HPLC columns
• HPLC systems
• Automation and sampling solutions
• Accessories and supporting hardware
• Method development and technical support

Our objective is to provide laboratories and analytical teams with more direct and reliable access to chromatography technologies backed by clear technical expertise.

Read AGBL’s official press release here:
https://agbl.net/agbl-announces-strategic-collaboration-with-sielc-technologies-to-advance-chromatography-solutions-across-emerging-markets/

We look forward to supporting analytical teams across these growing regions.

03/12/2026

🌍SIELC Technologies at Pittcon 2026
🔬We are pleased to share that our distributor Design Scientific represented SIELC Technologies solutions at Pittcon 2026 - one of the key international events in analytical chemistry.

For us, participation in industry events is not simply about presence, but about the steady expansion of our professional footprint in the global market. Pittcon remains an important platform for showcasing modern HPLC solutions and emerging technological approaches.

At the booth, the following were presented:
• Compact SIELC analyzers
• Chromatography columns
• Our new development - Single-Ended HPLC Column technology

We continue to develop solutions for laboratories where reproducibility, method stability, and thoughtful system engineering are essential - whether in research, industrial, or educational environments.

🤝 We thank the Design Scientific team for the professional presentation of our technologies

If you were unable to attend the exhibition, we would be pleased to discuss our solutions directly.

📩 [email protected]

03/11/2026

🔬 HPLC Method for Epibatidine Using Primesep 200
At SIELC Technologies, we have developed a reliable HPLC method for the analysis of epibatidine using the mixed-mode Primesep 200 stationary phase.

🔹 What is Epibatidine?
Epibatidine (C₁₁H₁₃ClN₃) is a highly potent alkaloid originally isolated from the Ecuadorian poison dart frog Ameerega anthonyi.
It exhibits strong nicotinic acetylcholine receptor activity and produces powerful analgesic effects. However, due to its extreme toxicity - potentially causing paralysis and respiratory arrest - it is not used therapeutically. Accurate chromatographic methods are essential for controlled research and analytical verification.

🔹 Why Primesep 200?
Primesep 200 is a mixed-mode analytical column with weak acidic ion-pairing groups embedded into long ligand chains.
✓ Enhances retention of strong basic compounds through cation-exchange mechanism
✓ Retains neutral compounds by reverse-phase mechanism
✓ Provides an additional interaction with polar molecules, enabling separation of isomers and structurally-related compounds
✓ Allows for mobile phase selection suitable for LC-MS and preparative chromatography, as well as low UV detection

⚙️ Typical HPLC Conditions
✅ Column: Primesep 200, 4.6 × 150 mm, 5 µm, 100 Å
✅ Mobile phase: MeCN/H₂O (30/70%)
✅ Modifier: 0.05% H₂SO₄
✅ Flow rate: 1.0 mL/min
✅ Detection: UV, 215 nm

🔗 Full Method: https://sielc.com/hplc-ms-separation-of-epibatidine
📩 For technical questions or custom method development support, contact us at [email protected]

02/10/2026

🔬 HPLC Method for Analysis of Malathion Using Primesep SB
At SIELC Technologies, we’ve developed a reliable HPLC method for the analysis of malathion, a widely used organophosphate pesticide, using the mixed-mode Primesep SB stationary phase.

🔹 What is Malathion?
Malathion (C₁₀H₁₉O₆PS₂) is heavily used in agricultural and public health pest control, especially for mosquito and fruit fly management. Although considered relatively low in toxicity to humans, it metabolizes into malaoxon - a significantly more toxic compound - making accurate analytical monitoring important in environmental and food safety testing.

🔹 Why Use the Primesep SB Column?
Primesep SB is a reverse-phase analytical column with strong embedded basic ion-pairing groups. It contains a C18 carbon chain and basic quaternary amine groups.
✓ Enhances retention of acidic compounds through anion-exchange mechanism
✓ Separates hydrophobic basic molecules using a combination of ion-exclusion and reverse-phase mechanism
✓ Retains neutral compounds by reverse-phase mechanism.
✓ Offers mobile phases suitable for LC-MS and preparative chromatography, as well as low UV detection (working pH range from 1.0 to 4.5)

⚙️ Typical HPLC Method Parameters
✅ Column: Primesep SB, 4.6 × 150 mm, 5 µm, 100 Å
✅ Mobile Phase: MeCN/H₂O (40/60%)
✅ Buffer: H₂SO₄, - 0.1%
✅ Flow Rate: 1.0 mL/min
✅ Detection: UV, 194 nm
This method provides a straightforward and robust approach for pesticide monitoring in environmental, regulatory, and food safety laboratories.

🔗 Full Method: https://sielc.com/hplc-ms-separation-of-malathion

📩 For technical questions or custom method development support, contact us at [email protected]

01/29/2026

🔬 High Performance Liquid Chromatography (HPLC) Method for Analysis of NAD and NADH
At SIELC Technologies, we’ve developed a simple and reliable HPLC method for the separation and UV detection of Nicotinamide Adenine Dinucleotide (NAD⁺) and its reduced form NADH using a PEI stationary phase.

🔹 What are NAD and NADH?
Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme present in all living cells. It exists in two interconvertible forms:
– NAD⁺ (oxidized form)
– NADH (reduced form)
The reversible conversion between NAD⁺ and NADH plays a central role in cellular redox reactions, energy metabolism, and electron transfer processes.

🔹 Why Use the PEI Column?
SIELC has engineered a PEI-specific column that combines ion-exclusion and size-exclusion mechanisms. This unique selectivity enables:
✓ Effective retention and separation of NAD and NADH
✓ High selectivity toward highly polar, charged biomolecules
✓ Reliable separation from excess inorganic ions and matrix components
✓ Simple mobile phase composition with UV detection

⚙️ Typical HPLC Method Parameters
✅ Column: PEI, 4.6 × 50 mm, 5 µm, 100 Å
✅ Mobile Phase: – MeCN/H2O – 60/40%
✅ Buffer: H₂SO₄, 0.2%
✅ Flow Rate: 1.0 mL/min
✅ Detection: UV, 264 nm

This method provides a straightforward and robust approach for NAD/NADH analysis in biochemical, pharmaceutical, and life science applications.

🔗 Full Method: https://sielc.com/hplc-uv-separation-of-nad-and-nadh-on-pei-column

📩 For technical questions or custom method development support, contact us at [email protected]

01/19/2026

HPLC Method for Phospholipids on Lipak™
Phospholipid analysis is never trivial. Structural diversity, amphiphilic behavior, and complex matrices often mean long method development and constant optimization.

Lipak™ was designed to change that.
Lipak™ employs mixed-mode chromatography, combining reversed-phase interactions with a highly polar functional group in the stationary phase. This dual-mode interaction enables efficient separation of lipids and other highly hydrophobic compounds, even within complex mixtures.

Why Lipak™
• Retention of both nonpolar and amphipathic lipid species
• High resolution with excellent reproducibility
• Improved selectivity across diverse lipid classes
• Optimized performance with high-organic mobile phases
• Inert hardware coating to reduce peak tailing
• Available in dual-ended and new single-ended designs
🔗 Learn more: https://sielc

01/07/2026

🔬 High Performance Liquid Chromatography (HPLC-MS) Method for Analysis of Sodium Dodecyl Sulfate (SDS)

At SIELC Technologies, we’ve developed a robust HPLC-MS method for the analysis of Sodium dodecyl sulfate (SDS) using the Lipak stationary phase - an effective solution for surfactant analysis in complex matrices.

🔹 What is Sodium Dodecyl Sulfate (SDS)?

– Also known as Sodium Lauryl Sulfate (SLS)

– Molecular formula: C₁₂H₂₅NaSO₄

– Structure: An anionic surfactant with a hydrophobic C12 alkyl chain and a polar sulfate group

– Applications:

• Cleaning and personal care products

• Food industry (emulsifier and whipping aid)

• Pharmaceuticals (ionic solubilizer and emulsifier)

• Laboratory workflows (cell lysis for RNA/DNA extraction)

🔹 Why Use the Lipak Column?

The Lipak column employs mixed-mode chromatography, combining reverse-phase interactions with a negatively charged group in the stationary phase. This enables:

✓ Simultaneous retention of polar and nonpolar species

✓ High resolution and reproducibility for complex lipid and surfactant mixtures

✓ LC-MS compatibility for confident identification and quantification

⚙️ Typical HPLC-MS Method Parameters

✅ Column: Lipak, 3.2 × 150 mm, 3 µm, 100 Å, dual-ended

✅ Mobile Phase: MeCN/H₂O gradient (60/40 → 90/10)

✅ Buffer: Ammonium formate 10 mM + 0.05% formic acid

✅ Flow Rate: 0.5 mL/min

✅ Detection: LC-MS, ESI, SIM, m/z 265 [M–H]⁻

✅ LOD: 8 ppm

*LOD was determined for this specific instrument, method, and analyte; values may vary between laboratories.

🔗 Full Method: https://sielc.com/hplc-method-for-sodium-dodecyl-sulfate

📩 For technical questions or custom method development support, contact us at [email protected]

12/24/2025

Dear Colleagues,

As Christmas is just around the corner, we would like to sincerely thank you for your trust and collaboration with SIELC Technologies.
Throughout the year, we were glad to support your work with our in-house developed HPLC columns and analyzers, as well as with method development and application expertise from our R&D team. We truly value this cooperation and look forward to continuing our work together.
Wishing you a warm and joyful Christmas, and a New Year ahead filled with successful experiments, reliable results, and new ideas.

Warm holiday wishes,
SIELC Technologies

Address

804 Seton Court
Wheeling, IL
60090

Opening Hours

Monday	9am - 6pm
Tuesday	9am - 6pm
Wednesday	9am - 6pm
Thursday	9am - 6pm
Friday	9am - 6pm

Telephone

+18472292629

Website

http://www.sielc.com/

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