MBF Bioscience

09/01/2026

As research questions get bigger and more complex, so do the experiments built to answer them. Imaging workflows increasingly span multiple instruments, real-time analysis, and decisions.

We're very excited to be developing an MHS driver for ScanImage as part of the Model Hardware Standard (MHS) research preview: a new standard for AI agents to safely operate physical equipment in scientific research and advanced manufacturing.

During the preview, we're testing how AI agents could support real-time data analysis and more connected imaging workflows, from acquisition through to the rest of the experiment, focusing on safety.

This MHS driver is being tested as part of the research preview, it is not a shipped feature. But we're glad to be testing what these new technologies could mean for microscopy.

Learn more about our work with MHS: https://www.mbfbioscience.com/mbf-bioscience-is-adding-native-support-for-the-model-hardware-standard-in-scanimage/

Read Anthropic's announcement on the MHS research preview: https://www.anthropic.com/news/model-hardware-standard-research-preview

08/31/2026

Join us at K-BRAIN 2026 for a luncheon seminar with Dr. Veronica Pessino, President of MBF Bioscience.

Her talk, “SLICE: A compact, accessible light-sheet microscopy platform for high-resolution 3D imaging of cleared tissue,” will highlight how SLICE brings high-performance volumetric imaging of cleared biological specimens to a compact platform designed for individual labs.

📅 September 7, 2026
🕐 13:10–13:40
📍 Room 103–104

We hope you can join us!
https://www.ksbns2026.org/

07/27/2026

Can the rapid antidepressant-like effects of psychedelics be separated from the side effects?

New research published in Molecular Psychiatry suggests they might. Using the FP3002 Fiber Photometry System, Yale University researchers tracked serotonin and norepinephrine activity in real time in the prefrontal cortex of mice. They found that M**A (but not psilocybin) triggered a robust release of norepinephrine alongside serotonin. That norepinephrine appeared to suppress the classic psychedelic behavioral signature while preserving psilocybin's antidepressant-like effects.

This study highlights how real-time neurochemical recording with the FP3002 Fiber Photometry System is helping researchers uncover the complex interactions between neuromodulators, advancing our understanding of brain function and supporting the development of more targeted neuropsychiatric therapies.

Read the study: https://www.nature.com/articles/s41380-026-03713-1

Classic serotonergic psychedelics such as psilocybin act as agonists at cortical serotonin (5-HT) 2A receptors (5-HT2AR), inducing psychedelic effects in humans and head-twitch responses (HTRs) in rodents. Another class of psychedelic drugs called entactogens, exemplified by M**A, function primarily...

07/07/2026

We're here at !

If you're attending the meeting, come visit us at Booth #154. We'd love to talk science, hear about your research, and share our latest innovations in imaging and neuroscience software.🔬🧠

We can't wait to see you!

06/29/2026

Heading to in Barcelona? Come find us at Booth #154, we'd love to show you what we've been working on.

We'll have live demos of:

🔬 SLICE™ - our award-winning light sheet microscope designed for accessible, high-performance 3D imaging

🧠 FP3002 - our fiber photometry platform for recording neural activity in freely moving animals

You'll also get a chance to explore our broader portfolio: neuron tracing, stereology, brain mapping, multiphoton imaging, and C. elegans behavior analysis.

Our team would love to hear about your research. Stop by and say hi!

📍 Booth #154
📅 6–10 July
https://fensforum.org/

06/24/2026

A new study published in Nature Methods by researchers at the Max Planck Institut für Neurobiologie des Verhaltens - caesar demonstrates simultaneous two- and three-photon multiplane imaging across cortical layers in freely moving mice, capturing activity from more than 1,800 neurons across five imaging planes in a single session.

The microscope's innovative design required precise, high-speed multiplexing across five imaging planes. Using ScanImage and high speed vDAQ the team recorded neuronal activity spanning superficial and deep cortical layers during complex decision-making behaviors, opening new possibilities for studying brain function in natural behaviors.

Congratulations to the authors on this exciting advance in neuroscience imaging.

Read more: https://www.nature.com/articles/s41592-026-03125-7

A lightweight head-mounted multiplane microscope allows simultaneous imaging from >1,800 neurons spread across the cortical layers in freely moving mice performing complex behavioral tasks, sampled over weeks.

06/23/2026

The impact of HySIL and scalable light-sheet microscopy continues to gain recognition.

Featured in Nature Biotechnology, a new Research Briefing highlights hybrid solid–liquid optics and their role in enabling scalable, high-resolution light-sheet microscopy.

The article discusses how this innovative approach can make advanced 3D imaging more affordable, flexible, and accessible to researchers worldwide.

We're excited to see the technology and concepts behind the award-winning SLICE light sheet microscope continue to be recognized by leaders in the field. We are proud to see Dr. Raju Tomer and collaborators' innovative work highlighted by Nature Biotechnology.

Read more: https://www.nature.com/articles/s41587-026-03209-x

Submicrometer-resolution three-dimensional (3D) imaging of large samples has been constrained by the short working distance, high cost and inflexible design of immersion objectives. We developed hybrid solid–liquid optics (HySIL) — a refractive framework with index-matched components — for sub...

06/12/2026

We're delighted to see this work highlighted by BioPhotonics.

HySIL and SCOPE represent exciting advances in optical design, helping deliver high-resolution 3D tissue imaging while reducing the cost and complexity traditionally associated with advanced microscopy.

We're proud to have collaborated on bringing these advances to researchers through the SLICE™ Light Sheet Microscope.

Modern biology and medicine increasingly depend on high-resolution, 3D images of intact tissues such as brains and cancer biopsies. The images allow r

06/11/2026

Great to see this work featured by Phys.org.

The article highlights the Nature Biotechnology publication from Dr. Raju Tomer and collaborators introducing HySIL and SCOPE, innovative optical technologies designed to make high-resolution 3D tissue imaging more accessible and scalable.

These advances have also been incorporated into the SLICE™ Light Sheet Microscope, helping bring powerful 3D imaging capabilities to researchers across neuroscience, developmental biology, cancer research, and pathology.

Read more: https://phys.org/news/2026-06-3d-microscope-technology-captures-high.html

A team led by Raju Tomer, professor of biological sciences at Columbia University, has created a new design for microscopes and microscope lenses that could push 3D tissue imaging beyond state-of-the-art systems while drastically cutting costs and complexity. Details of the design were published in....

06/09/2026

Exciting science news! 🎊

We're thrilled to share that Dr. Raju Tomer's laboratory at Columbia University has published major research in Nature Biotechnology—one of the world's leading journals in biotechnology and life sciences.

MBF Bioscience had the honor of supporting this work. Our SLICE light-sheet microscope—which we commercialized based on Dr. Tomer's pLSM invention—served as the platform to help validate SCOPE, a revolutionary optical technology his team developed.

The research team includes biologist collaborators from Columbia, NIH, Lehigh University, NYU Langone, and other institutions, demonstrating applications from whole-brain neuronal mapping to 3D cancer tissue imaging.

This is exactly the kind of collaboration we believe in: academic innovation creating new possibilities, with commercial partners helping make those advances accessible to researchers everywhere.

A huge congratulations to Dr. Tomer, the biologist collaborators, and all the researchers involved. We're grateful to support work that will accelerate discoveries in neuroscience, cancer research, and beyond.

Learn more: https://www.nature.com/articles/s41587-026-03172-7

Hybrid solid–liquid optics improve light-sheet imaging of intact biological samples.