MBF Bioscience

05/20/2026

We’re having a great time at the Canadian Association for Neuroscience Meeting in Montréal!

We’re here today and tomorrow. If you’re attending, stop by our booth to see live demos of:

🔬 SLICE™ light sheet microscope for accessible, high-performance 3D imaging
🧠 FP3002 for flexible fiber photometry experiments
🧬 Software solutions for neuron tracing, stereology, brain mapping, multiphoton imaging, and more

We’d love to hear about your research and imaging workflows and connect with more of the neuroscience community!
https://can-acn.org/meeting-2026/

05/19/2026

We’re excited to share that our article, “Light-Sheet Microscope Design Puts Whole-Brain Imaging in Reach for Scientists,” is featured as the cover article in the latest issue of BioPhotonics magazine!

The article highlights how the SLICE Light Sheet Microscope system combines projected light-sheet microscopy (pLSM), advanced optics for cleared tissue, and simplified system design to make high-performance whole-brain fluorescence imaging more accessible to researchers.

From subcellular-resolution imaging to large-scale brain mapping and connectomics, this approach brings advanced 3D imaging capabilities within reach of laboratories around the world.
A huge thank you to everyone involved in the development of this technology, especially Dr. Raju Tomer and collaborators at Columbia University.

📖 Read more about how accessible light-sheet microscopy is accelerating neuroscience research and whole-brain imaging: https://www.photonics.com/Articles/Light-Sheet-Microscope-Design-Puts-Whole-Brain/p1/vo269/i1950/a72116

Scientists once imagined a time when they would be able to acquire a complete subcellular-resolution 3D image of an entire mouse brain — all 600

05/15/2026

We’re excited to be heading to Montréal for the Canadian Association for Neuroscience Meeting 2026, taking place May 18–21!

If you’re attending, stop by our booth to see live demos of:

🔬 SLICE™: our award-winning light sheet microscope built to make high-performance 3D imaging more accessible and scalable.

🧠 FP3002 Fiber Photometry System: a flexible and powerful system for recording neural activity in freely-moving animals.

We'll also be showcasing solutions for neuron tracing, stereology, brain mapping, multiphoton imaging, and more.

Can’t wait to talk science, see what everyone’s working on, and connect with the neuroscience community!
https://can-acn.org/meeting-2026/

05/06/2026

We had a great time at the AQLM course (Marine Biological Laboratory) this week showcasing the SLICE light sheet microscope and connecting with some truly passionate researchers.

A big thank you to the AQLM team for organizing such a collaborative and engaging course, and to everyone who stopped by to ask questions, share ideas, and see SLICE in action.

We’re excited to be part of a community helping make advanced imaging more accessible. 🔬

05/01/2026

Join us at the Weinstein Cardiovascular Development & Regeneration Conference

📍 Hyatt Regency, Jersey City, NJ
📅 May 6–8

We’ll be showcasing 🔬 SLICE™, our award-winning light-sheet microscope built for fast, scalable, and accessible 3D imaging. If you’re working in vascular biology or large-scale 3D imaging, this is something worth seeing.

We’ll also be demoing Vesselucida® 360, our powerful image analysis software for automated vessel reconstruction and advanced morphometric analysis.

Stop by to see live demos, explore our full suite of imaging solutions, and chat about your research. We’d love to connect!

🔗 https://weinstein-conference.oa-event.com/

04/07/2026

New research is reshaping how we understand the adolescent brain, and Neurolucida played a key role. 🔬

A new study published in Science Advances found that during adolescence, a specific spine "hotspot" on primary somatosensory cortical neurons sees a dramatic, experience-dependent surge in dendritic spine density. When this accumulation failed to develop properly in mouse models of schizophrenia, researchers suggest that localized regulation of spine density is critical for maturing cognitive functions.

The study pairs Neurolucida with several imaging techniques, including super-resolution, confocal, and two-photon microscopy – creating precise maps of spine density and meaningful morphometric data.

The research reframes how we think about adolescent brain development and underscores the value of quantitative morphology in understanding the biology behind mental health disorders.

Huge congratulations to Ryo Egashira, Meng-Tsen Ke, Takeshi Imai, and team on this work.

🔗 Read the full study: https://www.science.org/doi/10.1126/sciadv.adw8458

Mouse models of schizophrenia show defects in adolescent spine formation in a specific dendritic compartment of L5 neurons.

03/30/2026

If you're at FOM 2026, come find us at booth 46! 👋

We're here showcasing how SLICE 🔬 is making high-resolution 3D imaging of cleared tissue more accessible, and today our own Matthew Fay is taking the stage to share how.

His talk will highlight how SLICE enables accessible, high-resolution 3D imaging of cleared tissues using advanced projected light-sheet microscopy (pLSM), along with a streamlined workflow for acquisition, visualization, and analysis.

📍 Session: New Developments in Commercial Instrumentation
🗓️ Today, March 30 | 16:30 – 16:50
📌 Room M12

Swing by the session or stop by our booth. We're always happy to geek out about imaging!

03/19/2026

Join us at Booth #46 at FOM 2026 in Stockholm (March 29 – April 1).

We're showcasing SLICE™, our award-winning light-sheet microscope for scalable, accessible, cost-effective high-performance 3D imaging, alongside our full suite of solutions including neuron tracing, stereology, multi-photon imaging, fiber photometry, brain mapping, and more.

📖 Attend Our Lecture: SLICE: Democratizing High-Resolution Light-Sheet Microscopy for Cleared Tissue Imaging
🗓 March 30 | 16:30–16:50 | Room M12

We look forward to seeing you in Stockholm! 🔬
https://www.focusonmicroscopy.org/

03/10/2026

We're excited to share our latest publication: "ClearScope: A Fully Integrated Light-Sheet Theta Microscope for Sub-Micron-Resolution Imaging Without Lateral Size Constraints" in the Journal of Imaging (MDPI). 🔬

One of the fundamental limitations of conventional light-sheet microscopy is that specimen lateral size is constrained by the orthogonal arrangement of illumination and detection optics — making it impossible to image intact large rodent brains, human brain tissue sections, or other clinically relevant samples in their entirety.

ClearScope overcomes this by employing light-sheet theta microscopy (LSTM) — using two oblique illumination paths with perpendicular detection — enabling subcellular-resolution 3D imaging of specimens with effectively unconstrained lateral dimensions.

In this study, we demonstrate:

• High-resolution 3D imaging of intact mouse and human brain samples

• Rapid imaging of optically cleared tissue while preserving molecular and cellular architecture

• Quantitative analysis — including neuron tracing, vascular reconstruction, and atlas-based image registration.

These capabilities open exciting possibilities for connectomics, systems neuroscience, cancer biology, and large-scale tissue studies. 🧠

ClearScope is a technological cousin to our newest light-sheet microscope SLICE , and together they represent MBF Bioscience's commitment to pushing the boundaries of what's possible in 3D biological imaging.

We're grateful to our collaborators at Columbia University and NYU Langone Health for their partnership in this work.

📄 Read the full open-access article: https://doi.org/10.3390/jimaging12030118

Three-dimensional (3D) ex vivo imaging of cleared tissue from intact brains from animal models, human brain surgical specimens, and large postmortem human and non-human primate brain specimens is essential for understanding physiological neural connectivity and pathological alterations underlying ne...

03/06/2026

🧠✨ NeuroArt Image Contest

Neuroscience isn't just about discovery. It's also about beauty.

We invite researchers, students, and imaging enthusiasts to submit their most captivating neuroscience images. Whether it’s neurons, brain tissue, or fluorescent microscopy, we want to see the artistry in your science.

Submit your image today!

https://neuroart.com/march-image-contest-2026/

02/11/2026

We're thrilled to share some big news at MBF Bioscience - the first leadership change in our nearly 40-year history.

Jack Glaser is moving from President to CEO, and we’re proud to announce that Veronica Pessino, PhD, has been promoted from COO to President.

As CEO, Jack will be focused on long-term strategy and partnerships. Dr. Veronica will be at the helm running day-to-day operations. This isn't Jack stepping back, it's us stepping up to meet the challenges ahead in the research community.

After 39 years of building MBF, we've never been more excited about where we're headed. Please join us in congratulating Dr. Veronica!

🔗 https://www.mbfbioscience.com/mbf-bioscience-announces-leadership-transition

MBF Bioscience announced that founder Jack Glaser has transitioned from President to CEO, and Veronica Pessino, PhD, has been promoted from COO to President.